Genomics Core Services

Precision genomics for every research need

The IGH Genomics Core at SUNY Downstate offers a comprehensive suite of next-generation sequencing platforms — from high-throughput bulk sequencing to single-cell resolution, spatially resolved transcriptomics, and long-read Oxford Nanopore technology.

Bulk Sequencing

High-Throughput • Transcriptome • Genome

Population-level RNA and DNA sequencing across millions of cells simultaneously. Ideal for differential gene expression studies, variant calling, epigenomics, and large-cohort designs requiring high depth and coverage.

Key Applications: RNA-seq, WGS/WES, ChIP-seq, ATAC-seq, amplicon sequencing

10x Genomics Single Cell

Fresh • Frozen • FFPE

Resolve cellular heterogeneity at single-cell resolution. We support fresh, cryopreserved, and FFPE tissue samples, bringing single-cell transcriptomics to archival and clinical specimens across a wide range of tissue types and conditions.

Key Applications: scRNA-seq, Multiome (RNA + ATAC), fresh tissue, frozen cells, FFPE

10x Spatial Transcriptomics

Visium • In-Tissue Gene Expression • FFPE Spatial

Map gene expression directly within intact tissue architecture. Our 10x Visium platform preserves the spatial context of gene expression, critical for characterizing tumor microenvironments, brain regions, and developmental tissue gradients.

Key Applications: Visium HD, FFPE spatial, H&E co-imaging, tissue mapping

Oxford Nanopore Sequencing

Long-Read • Real-Time • Direct RNA

Ultra-long read sequencing for structural variant detection, full-length isoform characterization, epigenetic base modification calling (methylation), and real-time adaptive sequencing. Ideal for applications where short-read platforms fall short.

Key Applications: Long-read WGS, direct RNA-seq, SV detection, CpG methylation