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Chella Kamarajan, PhD

Chella Kamarajan, PhD

Assistant Professor of Psychiatry | Chair, Research Committee of Psychiatry
Henri Begleiter Neurodynamics Lab
Department of Psychiatry and Behavioral Sciences

Profile

Dr. Chella Kamarajan, PhD, is an assistant professor of psychiatry and is affiliated with the Henri Begleiter Neurodynamics Laboratory (HBNL) at the department of Psychiatry. Dr. Kamarajan completed his PhD in clinical psychology with a focus in neuropsychology and neuroscience. Since joining the Neurodynamics Labin 2002, he has been affiliated with several NIH-funded research projects, including the Collaborative Study on the Genetics of Alcoholism (Current Role: Co-Investigator; PI: Bernice Porjesz), a multi-center consortium that aims to elucidate the role of genetic, neural, and environmental factors and their interactions in the development of alcohol use disorder and other related clinical traits. He is a co-principal investigator (MPI) in an NIH-funded R01 project that aims to understand neurocognitive and genomic factors underlying the risk of developing alcohol use disorder. Dr. Kamarajan has published 120+ peer-reviewed articles (23 first-author papers) on a range of topics, primarily focusing on neuroscience and genetics of addiction. His recent work involves novel measures from brain imaging datasets (EEG/ERP/ERO, s/fMRI, fNIRS) and translational applications of brain stimulation methods (rTMS, tDCS). He uses various machine learning methods to predict clinical outcomes. Currently, he is working on computing brain age (relative to one’s actual age) using neuroimaging and neurophysiological measures. Dr. Kamarajan is actively involved in didactic teaching and mentoring to medical students, psychiatry residents, and fellows. He serves as the chair of the research committee of psychiatry to train the residents and fellows during their research rotations. He is also the director of the research elective “Neuroelectric features in addiction” for the medical students. He serves on the editorial boards of many scientific journals and has guest-edited several special issues. He is a prolific reviewer for numerous scientific and professional journals (100+ reviews; 20+ journals). Dr. Kamarajan serves as an expert reviewer on the NIH/CSR study sections and other international funding agencies. Additionally, he has served as an international examiner to adjudicate doctoral dissertations (n=20+) from several universities abroad. Dr. Kamarajan is a member of many professional organizations, including the American Psychological Association, the International Organization of Psychophysiology, the Research Society on Alcohol, and the International Neuropsychoanalysis Society. Besides, he serves on several committees, including the Faculty and Staff Assembly (center-wide), College of Medicine Executive Committee, Dean’s Council for Education, Faculty Wellness Workgroup, and the Communication Committee of the SUNY Faculty Senate.

Education / Training / Employment

  • 2013 - Now — Assistant Professor (tenure-track), Department of Psychiatry, SUNY Downstate Health Sciences University, NY

  • 2008 - 2009 — Fellowship in Psychoanalysis, New York University Psychoanalytic Institute (NYUPI), NY
  • 2004 - 2013 — Research Scientist, Henri Begleiter Neurodynamics Lab, SUNY Downstate Health Sciences University, NY
  • 2002 - 2004 — Postdoctoral Research Fellow, Henri Begleiter Neurodynamics Lab, SUNY Downstate Health Sciences University, NY
  • 2000 - 2002 — Postdoctoral Clinical Fellow, National Institute of Mental Health and Neurosciences, Bangalore, India
  • 1996 - 2001 — Ph.D. (Clinical Psychology), National Institute of Mental Health and Neurosciences, Bangalore, India (Dissertation:  "Psychophysiological Correlates of Hypnosis in Functional Mental Disorders")
  • 1994 - 1996 — M.Phil. (Medical and Social Psychology), Central Institute of Psychiatry, Ranchi, India (Dissertation: "Premorbid Personality and Life Events in Functional Mental Disorders: Toward Evolving a Causal Model")
  • 1993 - 1994 — Research Assistant, Department of Psychiatry, Christian Medical College, Vellore, India
  • 1991 - 1993 — M.A. (Psychology), Annamalai University, Tamil Nadu, India

Number of Publications: 122 (on 2024-07-26)

Number of Citations: 3546 (as of 2024-07-26)

h-index = 30;   i10-index = 58

  • Paul SE, Baranger DAA, Johnson EC, Jackson JJ, Gorelik AJ, Miller AP, Hatoum AS, Thompson WK, Strube M, Dick DM, Kamarajan C, Kramer JR, Plawecki MH, Chan G, Anokhin AP, Chorlian DB, Kinreich S, Meyers JL, Porjesz B, Edenberg HJ, Agrawal A, Bucholz KK, Bogdan R (2024) Longitudinal Relationships Between Alcohol Milestones and Internalizing, Externalizing, and Executive Function, and Associations with Polygenic Scores. Psychological Medicine, 1-14. PMID: 38721768; DOI: 10.1017/S003329172400076X.
  • Barr P, Neale Z, Chatzinakos C, Schulman J, Mullins N, Zhang J, Chorlian D, Kamarajan C, Kinreich S, Pandey A, Pandey G, de Viteri SS, Acion L, Bauer L, Bucholz K, Chan G, Dick D, Edenberg H, Foroud T, Goate A, Hesselbrock V, Johnson E, Kramer J, Lai D, Plawecki M, Salvatore J, Wetherill L, Agrawal A, Porjesz B, Meyers J (2024) Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence. Research Square. PMID: 38405959; PMCID: PMC10889049; DOI: 10.21203/rs.3.rs-3894892/v1.
  • Chorlian DB, Kamarajan C, Meyers JL, Pandey AK, Zhang J, Kinreich S, Porjesz B (2024) Non-linear development of EEG coherence in adolescents and young adults shown by the analysis of neurophysiological trajectories and their covariance. bioRxiv, 2024.2003.2013.584867. PMID: 38559025; PMCID: PMC10980032; DOI: 10.1101/2024.03.13.584867.
  • Kamarajan C, Ardekani BA, Pandey AK, Meyers JL, Chorlian DB, Kinreich S, Pandey G, Richard C, de Viteri SS, Kuang W, Porjesz B (2024) Prediction of brain age in individuals with and at risk for alcohol use disorder using brain morphological features. bioRxiv, 2024.2003.2001.582844. PMID: 38496639; PMCID: PMC10942318; DOI: 10.1101/2024.03.01.582844.
  • Lai D, Kuo SI, Wetherill L, Aliev F, Zhang M, Marco A, Schwantes-An TH, Dick D, Francis MW, Johnson EC, Kamarajan C, Kinreich S, Kuperman S, Meyers J, Nurnberger JI, Liu Y, Edenberg HJ, Porjesz B, Agrawal A, Foroud T, Schuckit M, Plawecki MH, Bucholz KK, McCutcheon VV (2024) Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank. Alcohol: Clinical and Experimental Research, 48(2), 283-294. PMID: 38054532; DOI: 10.1111/acer.15239.
  • Li X, Liu J, Boreland AJ, Kapadia S, Zhang S, Stillitano AC, Abbo Y, Clark L, Lai D, Liu Y, Barr PB, Meyers JL, Kamarajan C, Kuang W, Agrawal A, Slesinger PA, Dick D, Salvatore J, Tischfield J, Duan J, Edenberg HJ, Kreimer A, Hart RP, Pang ZP (2024) Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model. bioRxiv, 2024.2002.2019.581066. DOI: 10.1101/2024.02.19.581066.
  • Prytkova I, Liu Y, Fernando M, Gameiro-Ros I, Popova D, Kamarajan C, Xuei X, Chorlian DB, Edenberg HJ, Tischfield JA, Porjesz B, Pang ZP, Hart RP, Goate A, Slesinger PA (2024) Upregulated GIRK2 counteracts ethanol-induced changes in excitability & respiration in human neurons. Journal of Neuroscience. PMID: 38350999; DOI: 10.1523/JNEUROSCI.0918-23.2024.
  • Thomas NS, Gillespie NA, Chan G, Edenberg HJ, Kamarajan C, Kuo SI, Miller AP, Nurnberger JI, Jr., Tischfield J, Dick DM, Salvatore JE (2024) A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency. Behavior Genetics, 54(2), 151-168. PMID: 38108996; PMCID: PMC10913412; DOI: 10.1007/s10519-023-10170-x.
  • Tobimatsu S, Kamarajan C (2024) Editorial: 15 years of frontiers in human neuroscience: neuromodulation. Frontiers in Human Neuroscience, 18; DOI: 10.3389/fnhum.2024.1380491.
  • Baghdadi G, Kamarajan C, Hadaeghi F (2023) Editorial: Role of brain oscillations in neurocognitive control systems. Frontiers in Systems Neuroscience, 17, 1182496. PMID: 37064159; PMCID: PMC10102580; DOI: 10.3389/fnsys.2023.1182496.
  • Barr PB, Neale Z, Schulman J, Mullins N, Zhang J, Chorlian DB, Kamarajan C, Kinreich S, Pandey AK, Pandey G, Saenz de Viteri S, Acion L, Bauer L, Bucholz KK, Chan G, Chao M, Dick DM, Edenberg HJ, Foroud T, Goate A, Hesselbrock V, Johnson EC, Kramer J, Lai D, Plawecki MH, Salvatore JE, Wetherill L, Agrawal A, Porjesz B, Meyers JL (2023) Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence. medRxiv. PMID: 37162915; PMCID: PMC10168504; DOI: 10.1101/2023.04.28.23289173.
  • Brislin SJ, Salvatore JE, Meyers JM, Kamarajan C, Plawecki MH, Edenberg HJ, Kuperman S, Tischfield J, Hesselbrock V, Anokhin AP, Chorlian DB, Schuckit MA, Nurnberger JI, Jr., Bauer L, Pandey G, Pandey AK, Kramer JR, Chan G, Porjesz B, Collaborators C, Dick DM (2023) Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. Psychological Medicine, 52(6), 1-11. PMID: 37203444; DOI: 10.1017/S0033291723001174.
  • Chorlian DB, Meyers JL, Manz N, Zhang J, Kamarajan C, Pandey A, Wang JC, Plawecki M, Edenberg H, Goate A, Tischfield J, Porjesz B (2023) Genetic influences vary by age and sex: Trajectories of the association of cholinergic system variants and theta band event related oscillations. bioRxiv. PMID: 36909650; PMCID: PMC10002625; DOI: 10.1101/2023.02.27.530318.
  • Colbert SMC, Mullins N, Chan G, Meyers JL, Schulman J, Kuperman S, Lai D, Nurnberger J, Plawecki MH, Kamarajan C, Anokhin AP, Bucholz KK, Hesselbrock V, Edenberg HJ, Kramer J, Dick DM, Porjesz B, Agrawal A, Johnson EC (2023) Polygenic Contributions to Suicidal Thoughts and Behaviors in a Sample Ascertained for Alcohol Use Disorders. Complex Psychiatry, 9(1-4), 11-23. PMID: 38058956; PMCID: PMC10697665; DOI: 10.1159/000529164.
  • Gameiro-Ros I, Popova D, Prytkova I, Pang ZP, Liu Y, Dick D, Bucholz KK, Agrawal A, Porjesz B, Goate AM, Xuei X, Kamarajan C, Coga Collaborators, Tischfield JA, Edenberg HJ, Slesinger PA, Hart RP (2023) 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics. Genes, Brain and Behavior, 22(5), e12855. PMID: 37533187; PMCID: PMC10550792; DOI: 10.1111/gbb.12855.
  • Johnson EC, Colbert SMC, Jeffries PW, Tillman R, Bigdeli TB, Karcher NR, Chan G, Kuperman S, Meyers JL, Nurnberger JI, Plawecki MH, Degenhardt L, Martin NG, Kamarajan C, Schuckit MA, Murray RM, Dick DM, Edenberg HJ, D'Souza DC, Di Forti M, Porjesz B, Nelson EC, Agrawal A (2023) Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users. Schizophrenia Bulletin, 49(3), 778-787. PMID: 36545904; PMCID: PMC10154717; DOI: 10.1093/schbul/sbac196.
  • Johnson EC, Salvatore JE, Lai D, Merikangas AK, Nurnberger JI, Tischfield JA, Xuei X, Kamarajan C, Wetherill L, Coga Collaborators, Rice JP, Kramer JR, Kuperman S, Foroud T, Slesinger PA, Goate AM, Porjesz B, Dick DM, Edenberg HJ, Agrawal A (2023) The collaborative study on the genetics of alcoholism: Genetics. Genes, Brain and Behavior, 22(5), e12856. PMID: 37387240; PMCID: PMC10550788; DOI: 10.1111/gbb.12856.
  • Kamarajan C (2023) Neurophysiological, Neuroimaging, and Neuropsychological Predictors of Human Alcoholism and Risk. Behavioral Sciences, 13(10), 790. DOI: 10.3390/bs13100790.
  • Kamarajan C, Pandey AK, Chorlian DB, Meyers JL, Kinreich S, Pandey G, Subbie-Saenz de Viteri S, Zhang J, Kuang W, Barr PB, Aliev F, Anokhin AP, Plawecki MH, Kuperman S, Almasy L, Merikangas A, Brislin SJ, Bauer L, Hesselbrock V, Chan G, Kramer J, Lai D, Hartz S, Bierut LJ, McCutcheon VV, Bucholz KK, Dick DM, Schuckit MA, Edenberg HJ, Porjesz B (2023) Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features. bioRxiv, 2022.2012.2030.522330. DOI: 10.1101/2022.12.30.522330.
  • Kamarajan C, Pandey AK, Chorlian DB, Meyers JL, Kinreich S, Pandey G, Subbie-Saenz de Viteri S, Zhang J, Kuang W, Barr PB, Aliev F, Anokhin AP, Plawecki MH, Kuperman S, Almasy L, Merikangas A, Brislin SJ, Bauer L, Hesselbrock V, Chan G, Kramer J, Lai D, Hartz S, Bierut LJ, McCutcheon VV, Bucholz KK, Dick DM, Schuckit MA, Edenberg HJ, Porjesz B (2023) Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features. Behavioral Sciences (Basel), 13(5), 427. PMID: 37232664; PMCID: PMC10215235; DOI: 10.3390/bs13050427.
  • Kuo SI, Thomas NS, Aliev F, Bucholz KK, Dick DM, McCutcheon VV, Meyers JL, Chan G, Kamarajan C, Kramer JR, Hesselbrock V, Plawecki MH, Porjesz B, Tischfield J, Salvatore JE (2023) Association of parental divorce, discord, and polygenic risk with children's alcohol initiation and lifetime risk for alcohol use disorder. Alcohol (Hoboken), 47(4), 724-735. PMID: 36807915; PMCID: PMC10149624; DOI: 10.1111/acer.15042.
  • Meyers JL, Brislin SJ, Kamarajan C, Plawecki MH, Chorlian D, Anohkin A, Kuperman S, Merikangas A, Pandey G, Kinreich S, Pandey A, Edenberg HJ, Bucholz KK, Coga Collaborators, Almasy L, Porjesz B (2023) The collaborative study on the genetics of alcoholism: Brain function. Genes, Brain and Behavior, 22(5), e12862. PMID: 37587903; PMCID: PMC10550791; DOI: 10.1111/gbb.12862.
  • Meyers JL, McCutcheon VV, Horne-Osipenko KA, Waters LR, Barr P, Chan G, Chorlian DB, Johnson EC, Kuo SI, Kramer JR, Dick DM, Kuperman S, Kamarajan C, Pandey G, Singman D, de Viteri SS, Salvatore JE, Bierut LJ, Foroud T, Goate A, Hesselbrock V, Nurnberger J, Plaweck MH, Schuckit MA, Agrawal A, Edenberg HJ, Bucholz KK, Porjesz B (2023) COVID-19 pandemic stressors are associated with reported increases in frequency of drunkenness among individuals with a history of alcohol use disorder. Translational Psychiatry, 13(1), 311. PMID: 37803048; DOI: 10.1038/s41398-023-02577-1.
  • Miller AP, Kuo SI, Johnson EC, Tillman R, Brislin SJ, Dick DM, Kamarajan C, Kinreich S, Kramer J, McCutcheon VV, Plawecki MH, Porjesz B, Schuckit MA, Salvatore JE, Edenberg HJ, Bucholz KK, Meyers JL, Agrawal A, Collaborative Study on the Genetics of A (2023) Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder. JAMA Network Open, 6(10), e2337192. PMID: 37815828; PMCID: PMC10565602; DOI: 10.1001/jamanetworkopen.2023.37192.
  • Miller AP, Kuo SIC, Johnson EC, Tillman R, Brislin SJ, Dick DM, Kamarajan C, Kinreich S, Kramer J, McCutcheon VV, Plawecki MH, Porjesz B, Schuckit MA, Salvatore JE, Edenberg HJ, Bucholz KK, Meyers JL, Agrawal A (2023) Specific diagnostic criteria identify those at high risk for progression from 'preaddiction' to severe alcohol use disorder. medRxiv, 2023.2006.2012.23291164. DOI: 10.1101/2023.06.12.23291164.
  • Mukundan CR, Kamarajan C, Priyanka K (2023) The World, Created By Human Minds. GAP BODHI TARU, 6(1), 22-28. LINK: https://www.gapbodhitaru.org/res/articles/(22-28)%20THE%20WORLD,%20CREATED%20BY%20HUMAN%20MINDS.pdf.
  • Pandey G, Kuo SI, Horne-Osipenko KA, Pandey AK, Kamarajan C, de Viteri SS, Kinreich S, Chorlian DB, Kuang W, Stephenson M, Kramer J, Anokhin A, Zang Y, Kuperman S, Hesselbrock V, Schuckit M, Dick D, Chan G, McCutcheon VV, Edenberg H, Bucholz KK, Meyers JL, Porjesz B (2023) Associations of parent-adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder. Alcohol: Clinical and Experimental Research, 47(1), 155-167. PMID: 36680783; DOI: 10.1111/acer.14973.
  • Popova D, Gameiro-Ros I, Youssef MM, Zalamea P, Morris AD, Prytkova I, Jadali A, Kwan KY, Kamarajan C, Salvatore JE, Xuei X, Chorlian DB, Porjesz B, Kuperman S, Dick DM, Goate A, Edenberg HJ, Tischfield JA, Pang ZP, Slesinger PA, Hart RP (2023) Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. Molecular Psychiatry, 28(2), 746-758. PMID: 36207584; PMCID: PMC9542475; DOI: 10.1038/s41380-022-01818-x.
  • Prytkova IA, Liu Y, Fernando MB, Gameiro-Ros I, Popova D, Kamarajan C, Xuei X, Chorlian DB, Edenberg HJ, Tischfield JA, Porjesz B, Pang ZP, Hart RP, Goate AM, Slesinger PA (2023) Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons. bioRxiv, 2023.2003.2022.533236. PMID: 36993693; PMCID: PMC10055374; DOI: 10.1101/2023.03.22.533236.
  • Saenz de Viteri S, Zhang J, Johnson EC, Barr PB, Edenberg HJ, Hesselbrock VM, Nurnberger JI, Jr., Pandey AK, Kamarajan C, Kinreich S, Tischfield JA, Plawecki MH, Kramer JR, Lai D, Kuperman S, Chan G, McCutcheon VV, Bucholz KK, Porjesz B, Meyers JL (2023) Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders. Molecular Psychiatry, 28(8), 3391-3396. PMID: 37344610; PMCID: PMC10618091; DOI: 10.1038/s41380-023-02117-9.
  • Schuckit MA, Smith TL, Danko G, Bucholz KK, Hesselbrock V, Hesselbrock M, Kuperman S, Kramer J, Nurnberger JI, Lai D, Chan G, Kamarajan C, Kuo S, Dick DM, Tear J, Mendoza LA, Edenberg HJ, Porjesz B (2023) Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response? Alcohol: Clinical and Experimental Research, 47(6), 1179-1190. PMID: 37073476; DOI: 10.1111/acer.15085.
  • Shah S, Shroff U, Gajiwala U, Galanter CA, Kamarajan C (2023) The Need for Psychiatric Care Among Visually Impaired Children with Traumatic Life Events: A Case Report from Rural India. Indian Journal of Mental Health, 10(2), 128-132. LINK: https://indianmentalhealth.com/pdf/2023/vol10-issue2/CR1_VISUALLY_IMPAIRED.pdf.
  • Su J, Kuo SI, Aliev F, Rabinowitz JA, Jamil B, Chan G, Edenberg HJ, Francis M, Hesselbrock V, Kamarajan C, Kinreich S, Kramer J, Lai D, McCutcheon V, Meyers J, Pandey A, Pandey G, Plawecki MH, Schuckit M, Tischfield J, Dick DM (2023) Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults. Development and Psychopathology, 1-13. PMID: 37781861; DOI: 10.1017/S0954579423001141.
  • Thomas NS, Salvatore JE, Kuo SI, Aliev F, McCutcheon VV, Meyers JM, Bucholz KK, Brislin SJ, Chan G, Edenberg HJ, Kamarajan C, Kramer JR, Kuperman S, Pandey G, Plawecki MH, Schuckit MA, Dick DM, Collaborators C (2023) Genetic nurture effects for alcohol use disorder. Molecular Psychiatry, 28(2), 759-766. PMID: 36253439; PMCID: PMC10079179; DOI: 10.1038/s41380-022-01816-z.
  • Barr PB, Driver MN, Kuo SI, Stephenson M, Aliev F, Linner RK, Marks J, Anokhin AP, Bucholz K, Chan G, Edenberg HJ, Edwards AC, Francis MW, Hancock DB, Harden KP, Kamarajan C, Kaprio J, Kinreich S, Kramer JR, Kuperman S, Latvala A, Meyers JL, Palmer AA, Plawecki MH, Porjesz B, Rose RJ, Schuckit MA, Salvatore JE, Dick DM (2022) Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts. Molecular Psychiatry, 27(11), 4633-4641. PMID: 36195638; PMCID: PMC9938102; DOI: 10.1038/s41380-022-01801-6.
  • Barr PB, Driver MN, Kuo SIC, Stephenson M, Aliev F, Linner RK, Anokhin AP, Bucholz K, Chan G, Edenberg HJ, Edwards AC, Francis MW, Harden KP, Kamarajan C, Kaprio J, Kinreich S, Kramer J, Kuperman S, Latvala A, Meyers JL, Palmer AA, Plawecki MH, Porjesz B, Rose RJ, Schuckit MA, Salvatore JE, Dick DM (2022) Predicting Substance Use Disorders: A Multifactorial Risk Index Combining Clinical, Environmental, and Genetic Risk Factors. medRxiv, 2022.2001.2027.22269750. DOI: 10.1101/2022.01.27.22269750.
  • Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linner RK, Porjesz B, Hesselbrock V, Foroud T, Agrawal A, Dick D, Edenberg HJ, Nurnberger J, Jr., Liu Y, Kuperman S, Kramer J, Meyers J, *Kamarajan C, Pandey A, Bierut L, Rice J, Bucholz K, Schuckit M, Tischfield J, Hart R, Salvatore J, Almasy L, Goate A, Kapoor M, Slesinger P, Scott D, Bauer L, Wetherill L, Xuei X, Lai D, O’Connor S, Plawecki M, Acion L, Chan G, Chorlian DB, Zhang J, Kinreich S, Pandey G, Chao M, Anokhin A, McCutcheon V, Saccone S, Aliev F, Chin H, Parsian A, Waldman ID, Palmer AA, Harden KP, Dick DM (2022) Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk. Translational Psychiatry, 12(1), 420. PMID: 36180423; PMCID: PMC9525649; DOI: 10.1038/s41398-022-02171-x.
  • Brislin SJ, Salvatore JE, Meyers JL, Kamarajan C, Plawecki MH, Edenberg HJ, Kuperman S, Tischfield J, Hesselbrock V, Anokhin A, Chorlian D, Schuckit MA, Nurnberger J, Bauer L, Pandey G, Pandey AK, Kramer J, Chan G, Porjesz B, Dick D (2022) Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. PsyArXiv; DOI: 10.31234/osf.io/b64f9.
  • Colbert SMC, Mullins N, Chan G, Meyers JL, Schulman J, Kuperman S, Lai D, Nurnberger J, Plawecki MH, Kamarajan C, Anokhin AP, Bucholz KK, Hesselbrock V, Edenberg HJ, Kramer J, Dick DM, Porjesz B, Agrawal A, Johnson EC (2022) Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders. medRxiv, 2022.2008.2018.22278943. DOI: 10.1101/2022.08.18.22278943.
  • Francis MW, Bourdon JL, Chan G, Dick DM, Edenberg HJ, Kamarajan C, Kinreich S, Kramer J, S ICK, Pandey AK, Pandey G, Smith RL, Bucholz KK, McCutcheon VV (2022) Deriving a Measure of Social Recovery Capital From the Important People and Activities Instrument: Construction and Psychometric Properties. Alcohol and Alcoholism, 57(3), 322-329. PMID: 35356964; PMCID: PMC9086804; DOI: 10.1093/alcalc/agac014.
  • Kamarajan C, Ardekani BA, Pandey AK, Kinreich S, Pandey G, Chorlian DB, Meyers JL, Zhang J, Bermudez E, Kuang W, Stimus AT, Porjesz B (2022) Differentiating Individuals with and without Alcohol Use Disorder Using Resting-State fMRI Functional Connectivity of Reward Network, Neuropsychological Performance, and Impulsivity Measures. Behavioral Sciences (Basel), 12(5), 128. PMID: 35621425; PMCID: PMC9137599; DOI: 10.3390/bs12050128.
  • Kuo SI, Poore HE, Barr PB, Chirico IS, Aliev F, Bucholz KK, Chan G, Kamarajan C, Kramer JR, McCutcheon VV, Plawecki MH, Dick DM (2022) The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance. Development and Psychopathology, 1-11. PMID: 36200344; DOI: 10.1017/S0954579422000700.
  • Lai D, Johnson EC, Colbert S, Pandey G, Chan G, Bauer L, Francis MW, Hesselbrock V, Kamarajan C, Kramer J, Kuang W, Kuo S, Kuperman S, Liu Y, McCutcheon V, Pang Z, Plawecki MH, Schuckit M, Tischfield J, Wetherill L, Zang Y, Edenberg HJ, Porjesz B, Agrawal A, Foroud T (2022) Evaluating risk for alcohol use disorder: Polygenic risk scores and family history. Alcoholism: Clinical and Experimental Research, 46(3), 374-383. PMID: 35267208; PMCID: PMC8928056; DOI: 10.1111/acer.14772.
  • Lai D, Schwantes-An TH, Abreu M, Chan G, Hesselbrock V, Kamarajan C, Liu Y, Meyers JL, Nurnberger JI, Jr., Plawecki MH, Wetherill L, Schuckit M, Zhang P, Edenberg HJ, Porjesz B, Agrawal A, Foroud T (2022) Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. medRxiv, 2022.2001.2019.22269532. DOI: 10.1101/2022.01.19.22269532.
  • Lai D, Schwantes-An TH, Abreu M, Chan G, Hesselbrock V, Kamarajan C, Liu Y, Meyers JL, Nurnberger JI, Jr., Plawecki MH, Wetherill L, Schuckit M, Zhang P, Edenberg HJ, Porjesz B, Agrawal A, Foroud T (2022) Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. Translational Psychiatry, 12(1), 266. PMID: 35790736; DOI: 10.1038/s41398-022-02029-2.
  • Merikangas AK, Kember RL, Plawecki MH, Kamarajan C, Chan G, Bauer L, Meyers JL, Nurnberger JI, Kramer J, Porjesz B, Edenberg HJ, Almasy L (2022) Is anxiety a pathway to Alcohol Use Disorders? A phenome-wide association study of the GABRA2 coding variant rs279858. medRxiv, 2022.2011.2021.22282301. DOI: 10.1101/2022.11.21.22282301.
  • Mukundan CR, Kamarajan C (2022) Brain to Mind - Cognitive and Emotional Journey within the Human Brain. EC Neurology, 14(2), 01-08. LINK: https://www.ecronicon.com/ecne/pdf/ECNE-14-00994.pdf.
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  • Meyers JL, Zhang J, Wang JC, Su J, Kuo SI, Kapoor M, Wetherill L, Bertelsen S, Lai D, Salvatore JE, Kamarajan C, Chorlian D, Agrawal A, Almasy L, Bauer L, Bucholz KK, Chan G, Hesselbrock V, Koganti L, Kramer J, Kuperman S, Manz N, Pandey A, Seay M, Scott D, Taylor RE, Dick DM, Edenberg HJ, Goate A, Foroud T, Porjesz B (2017) An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. Molecular Psychiatry, 22(12), 1767-1775. PMID: 28070124; PMCID: PMC5503794; DOI: 10.1038/mp.2016.239.
  • Pandey AK, Kamarajan C, Manz N, Chorlian DB, Stimus A, Porjesz B (2016) Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65, 158-171. PMID: 26456730; PMCID: PMC4679474; DOI: 10.1016/j.pnpbp.2015.10.002.
  • Chorlian DB, Rangaswamy M, Manz N, Kamarajan C, Pandey AK, Edenberg H, Kuperman S, Porjesz B (2015) Gender modulates the development of theta event related oscillations in adolescents and young adults. Behavioural Brain Research, 292(1), 342-352. PMID: 26102560; PMCID: PMC4705839; DOI: 10.1016/j.bbr.2015.06.020.
  • Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Anokhin AP, Bauer LO, Kuperman S, Kramer J, Bucholz KK, Schuckit MA, Hesselbrock VM, Porjesz B (2015) Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. PLOS ONE, 10(11), e0142659. PMID: 26580209; PMCID: PMC4651365; DOI: 10.1371/journal.pone.0142659.
  • Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Bauer LO, Hesselbrock VM, Schuckit MA, Kuperman S, Kramer J, Porjesz B (2015) Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. International Journal of Psychophysiology, 98(2 Pt 1), 182-200. PMID: 26388585; PMCID: PMC4898464; DOI: 10.1016/j.ijpsycho.2015.09.005.
  • Kamarajan C, Pandey AK, Chorlian DB, Porjesz B (2015) The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. International Journal of Psychophysiology, 97(3), 310-322. PMID: 25448264; PMCID: PMC4422780; DOI: 10.1016/j.ijpsycho.2014.10.013.
  • Kamarajan C, Porjesz B (2015) Advances in Electrophysiological Research. Alcohol Research: Current Reviews, 37(1), 53-87. PMID: 26259089; PMCID: PMC4476604. LINK: https://www.ncbi.nlm.nih.gov/pubmed/26259089.
  • Mukundan CR, Kamarajan C, Ajayan P, Roopesh BN, Sharma M (2013) The frontal cortex and recognition: Neurocognitive findings of hypnosis. Indian Journal of Health and Wellbeing, 4(4), 703-710. LINK: http://www.i-scholar.in/index.php/ijhw/article/view/92255.
  • Kamarajan C, Porjesz B (2012) Brain waves in Impulsivity Spectrum Disorders. In: Cyders MA (ed.), Psychology of Impulsivity, Nova Science Publishers, Hauppauge, NY, pp. 20-93. LINK: https://novapublishers.com/shop/psychology-of-impulsivity/.
  • Kamarajan C, Rangaswamy M, Manz N, Chorlian DB, Pandey AK, Roopesh BN, Porjesz B (2012) Topography, power, and current source density of theta oscillations during reward processing as markers for alcohol dependence. Human Brain Mapping, 33(5), 1019-1039. PMID: 21520344; PMCID: PMC3763910; DOI: 10.1002/hbm.21267.
  • Pandey AK, Kamarajan C, Rangaswamy M, Porjesz B (2012) Event-Related Oscillations in Alcoholism Research: A Review. Journal of Addiction Research & Therapy, Suppl 7(1), 1-13. PMID: 24273686; PMCID: PMC3835599; DOI: 10.4172/2155-6105.S7-001.
  • Pandey AK, Kamarajan C, Tang Y, Chorlian DB, Roopesh BN, Manz N, Stimus A, Rangaswamy M, Porjesz B (2012) Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. Biological Psychology, 89(1), 170-182. PMID: 22024409; PMCID: PMC3245806; DOI: 10.1016/j.biopsycho.2011.10.009.
  • Rao NR, Kodali R, Mian A, Ramtekkar U, Kamarajan C, Jibson MD (2012) Psychiatric residents' attitudes toward and experiences with the clinical-skills verification process: a pilot study on U.S. and international medical graduates. Academic Psychiatry, 36(4), 316-322. PMID: 22851030; DOI: 10.1176/appi.ap.11030051.
  • Garrett M, Singh A, Amanbekova D, Kamarajan C (2011) Lack of insight and conceptions of “mental illness” in schizophrenia, assessed in the third person through case vignettes. Psychosis, 3(2), 115-125. DOI: 10.1080/17522439.2010.529618.
  • Kamarajan C, Rangaswamy M, Tang Y, Chorlian DB, Pandey AK, Roopesh BN, Manz N, Saunders R, Stimus AT, Porjesz B (2010) Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. Journal of Psychiatric Research, 44(9), 576-590. PMID: 20035952; PMCID: PMC2878886; DOI: 10.1016/j.jpsychires.2009.11.019.
  • Roopesh BN, Rangaswamy M, Kamarajan C, Chorlian DB, Pandey AK, Porjesz B (2010) Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm. Alcoholism: Clinical and Experimental Research, 34(11), 1905-1914. PMID: 20659074; PMCID: PMC3601919; DOI: 10.1111/j.1530-0277.2010.01279.x.
  • Kamarajan C, Porjesz B, Rangaswamy M, Tang Y, Chorlian DB, Padmanabhapillai A, Saunders R, Pandey AK, Roopesh BN, Manz N, Stimus AT, Begleiter H (2009) Brain signatures of monetary loss and gain: outcome-related potentials in a single outcome gambling task. Behavioural Brain Research, 197(1), 62-76. PMID: 18775749; PMCID: PMC2645043; DOI: 10.1016/j.bbr.2008.08.011.
  • Roopesh BN, Rangaswamy M, Kamarajan C, Chorlian DB, Stimus A, Bauer LO, Rohrbaugh J, O'Connor SJ, Kuperman S, Schuckit M, Porjesz B (2009) Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. Alcoholism: Clinical and Experimental Research, 33(12), 2027-2036. PMID: 19764939; PMCID: PMC3601897; DOI: 10.1111/j.1530-0277.2009.01042.x.
  • Kamarajan C, Rangaswamy M, Chorlian DB, Manz N, Tang Y, Pandey AK, Roopesh BN, Stimus AT, Porjesz B (2008) Theta oscillations during the processing of monetary loss and gain: a perspective on gender and impulsivity. Brain Research, 1235, 45-62. PMID: 18616934; PMCID: PMC2650440; DOI: 10.1016/j.brainres.2008.06.051.
  • Chen AC, Porjesz B, Rangaswamy M, Kamarajan C, Tang Y, Jones KA, Chorlian DB, Stimus AT, Begleiter H (2007) Reduced frontal lobe activity in subjects with high impulsivity and alcoholism. Alcoholism: Clinical and Experimental Research, 31(1), 156-165. PMID: 17207114; DOI: 10.1111/j.1530-0277.2006.00277.x.
  • Rangaswamy M, Jones KA, Porjesz B, Chorlian DB, Padmanabhapillai A, Kamarajan C, Kuperman S, Rohrbaugh J, O'Connor SJ, Bauer LO, Schuckit MA, Begleiter H (2007) Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. International Journal of Psychophysiology, 63(1), 3-15. PMID: 17129626; PMCID: PMC2020838; DOI: 10.1016/j.ijpsycho.2006.10.003.
  • Jones KA, Porjesz B, Chorlian D, Rangaswamy M, Kamarajan C, Padmanabhapillai A, Stimus A, Begleiter H (2006) S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism. Clinical Neurophysiology, 117(10), 2128-2143. PMID: 16926113; DOI: 10.1016/j.clinph.2006.02.028.
  • Kamarajan C, Porjesz B, Jones K, Chorlian D, Padmanabhapillai A, Rangaswamy M, Stimus A, Begleiter H (2006) Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism. Biological Psychiatry, 59(7), 625-634. PMID: 16213472; PMCID: PMC3766847; DOI: 10.1016/j.biopsych.2005.08.017.
  • Padmanabhapillai A, Porjesz B, Ranganathan M, Jones KA, Chorlian DB, Tang Y, Kamarajan C, Rangaswamy M, Stimus A, Begleiter H (2006) Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. International Journal of Psychophysiology, 60(1), 15-26. PMID: 16019097; DOI: 10.1016/j.ijpsycho.2005.03.026.
  • Padmanabhapillai A, Tang Y, Ranganathan M, Rangaswamy M, Jones KA, Chorlian DB, Kamarajan C, Stimus A, Kuperman S, Rohrbaugh J, O'Connor SJ, Bauer LO, Schuckit MA, Begleiter H, Porjesz B (2006) Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. International Journal of Psychophysiology, 62(2), 262-271. PMID: 16887227; DOI: 10.1016/j.ijpsycho.2006.05.012.
  • Kamarajan C, Porjesz B, Jones KA, Choi K, Chorlian DB, Padmanabhapillai A, Rangaswamy M, Stimus AT, Begleiter H (2005) Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task. Biological Psychology, 69(3), 353-373. PMID: 15925035; PMCID: PMC3758477; DOI: 10.1016/j.biopsycho.2004.08.004.
  • Kamarajan C, Porjesz B, Jones KA, Chorlian DB, Padmanabhapillai A, Rangaswamy M, Stimus AT, Begleiter H (2005) Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. Clinical Neurophysiology, 116(5), 1049-1061. PMID: 15826845; PMCID: PMC3785104; DOI: 10.1016/j.clinph.2004.12.015.
  • Porjesz B, Rangaswamy M, Kamarajan C, Jones KA, Padmanabhapillai A, Begleiter H (2005) The utility of neurophysiological markers in the study of alcoholism. Clinical Neurophysiology, 116(5), 993-1018. PMID: 15826840; DOI: 10.1016/j.clinph.2004.12.016.
  • Kamarajan C, Porjesz B, Jones KA, Choi K, Chorlian DB, Padmanabhapillai A, Rangaswamy M, Stimus AT, Begleiter H (2004) The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. International Journal of Psychophysiology, 51(2), 155-180. PMID: 14693365; PMCID: PMC3766846; DOI: 10.1016/j.ijpsycho.2003.09.004.
  • Mukundan CR, Ramachandra S, Singh N, Sharma M, Kamarajan C (1999) Brain mechanisms of hypnosis: P300 studies. Indian Journal of Clinical Psychology, 26(1), 13-23. LINK: https://www.researchgate.net/publication/235624403_Brain_mechanisms_of_hypnosis_P300_studies.

CURRENT FUNDING SUPPORT

(i) R01-AA028848: Bernice Porjesz (PI), Chella Kamarajan (MPI), Jacquelyn Meyers (MPI), Ashwini Pandey (MPI) 09/20/2021 – 06/30/2026 [Sponsor: NIAAA]

  • Title: Brain Function and Neurogenomic influences on AUD risk and resilience
  • Goals: To understand neurocognitive and genomic factors underlying risk and consequences of alcohol use disorder.
  • Role: Co-Principal Investigator
  • Funding Period: 09/20/2021 – 06/30/2026

 

(ii) U10-AA008401: Bernice Porjesz (National PI) 09/05/2019 – 08/31/2024 [Sponsor: NIAAA & NIDA]

  • Title: Collaborative Study on the Genetics of Alcoholism (COGA) Co-funding by NIAAA and NIDA
  • Goals: To elucidate genetic, familial, environmental factors and their interactions in the cause, course, symptoms, and manifestations of alcoholism and other co-occurring psychiatric disorders
  • Role: Co-Investigator
  • Funding Period: 09/05/2019 – 08/31/2024