Raavi Gupta, MD

Office

A2-406A

Research or Clinical Interest Summary

My research interests include hematopoietic neoplasms including myelodysplastic syndrome and biology of cancer in different ethnic populations.

Grants:

Principal Investigator at Downstate: R Gupta, M.D.
Department of Defense - W81XWH-20-PCRP-HDRA
07/01/2021 – 06/30/2023
Novel complex structural variants and epigenetic alterations link the genomes of prostate cancer in African Americans with outcome disparity.  The goal of this project is to identify and interrogate the underlying genetic differences that contribute to worse outcomes in men of African descent with prostate cancer. The project will identify novel complex structural variants and epigenetic changes in prostate cancer that contribute to disease progression in African American men, and correlate with outcomes disparities

Research Support:

Principal Investigator: R Gupta, MD
miR Diagnostics
09/10/2018- 09/09/2019
Development of new screening tests for diagnosing urological cancer through ‘liquid biopsies’, especially focusing on the African American patients, who have not been adequately represented in other test development studies

Co-Investigator: R. Gupta, M.D.
NIH - P20
10/01/2015-09/30/2019
Feasibility studies to build collaborative partnerships in cancer research to study racial/ethnic differences in GI cancer biology.

Principal Investigator at Downstate: R Gupta, M.D.
NIH Health Disparities Seed Funding Program
2019 - 2020
Racial Disparities in TNBC: Role of Clusters of Enhancers and associated lncRNAs
In a joint Albany and Downstate effort we are studying super-enhancers and long noncoding RNAs that drive aberrant activation of oncogenic pathways in African American women. The knowledge of these genetic risk factors will enhance our understanding of the biology of breast cancer in African American women and help identify genes that could be used to develop targeted therapies.

Book Chapter

Gupta, R., Nowakowski, M. & Haseeb, M.A. 2015. Human protozoal infections and their potential for causing neoplasms. In M.R. Shurin, Y. Thanavaka & N. Ismail (eds), Infection and Cancer: Bi-Drectional Interactions.. Springer, Berlin. pp. 75-91.

• McEachron J, Baqir AW, Zhou N, Jabbar A, Gupta R, Levitan D, Lee Y-C. Evaluation of the incidence and clinical significance of WT-1 expression in uterine serous carcinoma. Gynecol Oncol Rep. 2021 Dec;39:100918. PMID: 35024404
• Kim T, Yu J, Li H, Scarupa M, Wasserman RL, Economides A, White M, Ward C, Shah A, Jones D, Rathkopf M, Frye K, Aybar A, Shayegan S, Enav B, Ispas L, Loizou D, Fitzhugh D, Tracy J, Friedlander J, Jacobs Z, Matz J, Golden D, McNeil D, McCann W, Copenhaver C, Factor J, Gupta R, et al. Validation of inducible basophil biomarkers: Time, temperature and transportation. Cytometry B Clin Cytom. 2021 Nov;100(6):632-644 . PMID: 33539657.
• Abstract:  Salahi N, Jabbar A, Gupta R, Levitan D. Adenoid basal carcinoma with adenoid cystic-like features, a rare diagnostic dilemma. Poster presentation. American Society for Clinical Pathology Annual meeting (Virtual), October 27-29, 2021.
• Waqar, SH, Zaman, U, Salahi, N, Gupta, R, McFarlane, IM. A perplexing case of recurrent abscess-like lesions: Insights into primary cutaneous diffuse large B-cell lymphoma, Leg type. Sept 2021. 2021 Sep;13(9):e17766. PMID: 34659977
• Lin B, Rabinowitz S, Haseeb MA, Gupta R. Usefulness of the eosinophilic esophagitis histologic scoring system in distinguishing active eosinophilic esophagitis from remission and gastroesophageal reflux disease. Gastroenterology Res. 2021 Aug;14(4):220-226 PMID: 34527091
• Mendoza RP, Haidary T, Gabutan E, Zhou YY, Bukhari Z, Connelly CC, Lee W, Lee Y, Wadgaonkar R, Agrawal R, Haseeb MA, Gupta R. Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer. Sci Rep. 2021 Jul;11(1):14064. PMID: 34234252
• Abstract:  Plassmeyer, M, Alpan, O, Corley, MJ, Lillard, K, Coatney, P, Vaziri, T, Michalsky, S, Premeaux, TA, Pang, APS, Bukhari, Z, Yueng, ST, Evering, TH, Naughton, G, Latterich, M, Mudd, P, Spada, A, Rindone, N, Loizou, D, Ndhlovu, LC, Gupta, R. Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS CoV2 infection and long COVID. Platform presentation at the Digital World Immune Regulation Meeting XV with special focus on “immune activation, effector functions and immune tolerance with a special focus on autoimmunity and allergy" (Virtual), June 30 - July 3, 2021.

• McEachron, J., Baqir, AW., Zhou,N., Jabbar,A., Gupta,R., Levitan, D and Lee, YC. Evaluation of the incidence and clinical significance of WT-1 expression in uterine serous carcinoma. Gynecologic Oncology Reports, Article 100918 (in press).

• Kim T, Yu J, Li H, Scarupa M, Wasserman RL, Economides A, White M, Ward C, Shah A, Jones D, Rathkopf M, Frye K, Aybar A, Shayegan S, Enav B, Ispas L, Loizou D, Fitzhugh D, Tracy J, Friedlander J, Jacobs Z, Matz J, Golden D, McNeil D, McCann W, Copenhaver C, Factor J, Gupta R, Alpan O, Plassmeyer M, Sønder SU. 2021. Validation of inducible basophil biomarkers: Time, temperature and transportation. Cytometry B Clin Cytom, 100(6):632-644. doi: 10.1002/cyto.b.21991. PMID: 33539657.

• Waqar, SH., Zaman, U., Salahi, N., Gupta, R., McFarlane, IM. A perplexing case of recurrent abscess-like lesions: Insights into primary cutaneous diffuse large B-cell lymphoma, Leg type. 2021. Cureus.10.7759/cureus.17766

• Lin, B., Rabinowitz, S., Haseeb, M.A., Gupta, R. 2021. Usefulness of the eosinophilic esophagitis histologic scoring system in distinguishing active eosinophilic esophagitis from remission and gastroesophageal reflux disease. Gastroentrology Research. 14(4):220-226. doi: 10.14740/gr1423. PMID: 34527091; PMCID: PMC8425795.

• Mendoza, R.P., Haidary, T., Gabutan, E., Zhou, Y.Y., Bukhari, Z., Connelly, C.C., Lee, W., Lee, Y., Wadgaonkar, R., Agrawal, R., Haseeb, M.A, Gupta, R. 2021. Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer. Scientific Reports, 11, 14064. https://doi.org/10.1038/s41598-021-93485-1

• Plassmeyer, M., Alpan, O., Corley, MJ., Lillard, K., Coatney, P., Vaziri, T., Michalsky, S., Premeaux, T.A., Pang, APS., Bukhari, Z., Yueng, ST., Evering, TH., Naughton, G., Latterich, M., Mudd, P., Spada, A., Rindone, N., Loizou, D., Ndhlovu, LC., Gupta, R. 2021.  Caspases in COVID-19 Disease and Sequela and the Therapeutic Potential of Caspase Inhibitors. Allergy, doi: 10.1111/all.14907. PMID: 33993490.

• Patterson, BK., Seethamraju, H., Dhod,y K., Corley, MJ., Kazempour, K., Lalezari, J., Pang, APS., Sugai, C., Mahyari, E., Francisco, EB., Pise, A., Rodrigues, H., Wu, HL., Webb, GM., Park, BS., Kelly, S., Pourhassan, N., Lelic, A., Kdouh, L., Herrera, M., Hall, E., Bimber, BN., Plassmeyer, M., Gupta, R., Alpan, O., O'Halloran, JA., Mudd, PA., Akalin, E., Ndhlovu, LC., Sacha, JB. 2021. CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14. Int J Infect Dis, 103:25-32. doi: 10.1016/j.ijid.2020.10.101. Epub 2020 Nov 10. PMID: 33186704; PMCID: PMC7654230.

• Gupta, R., Agrawal, R., Bukhari,Z., Jabbar,A., Wang,D., Diks,J., Alshal, M., Emechebe, D.Y., Brunicardi, F.C., Lazar,J.M., Chamberlain,R., Burza, A., Haseeb,M.A. 2021. Higher Comorbidities and Early Death in Hospitalized African-American Patients with Covid-19. BMC Infect Dis, 21, 78. https://doi.org/10.1186/s12879-021-05782-9

• Kim, T, Yu, J., Li, H., Scarupa, M., Wasserman, RL., Economides, A., White, M., Ward, C., Shah, A., Jones, D., Rathkopf, M., Frye, K., Aybar, A., Shayegan, S., Enav, B., Ispas, L., Loizou, D., Fitzhugh, D., Tracy, J., Friedlander, J., Jacobs, Z., Matz, J., Golden, D., McNeil, D., McCann, W., Copenhaver, C., Factor, J., Gupta, R., Alpan, O., Plassmeyer, M., Ulrik, SS. 2021.Validation of inducible basophil biomarkers: Time, Temperature and Transportation" has been accepted for publication in the next available issue of Cytometry: Part B - Clinical Cytometry, doi: 10.1002/cyto.b.21991. Epub ahead of print. PMID: 33539657.

• Damania, D., Chow, L., Betancourt, B., Mahoney, J., Haseeb, M.A., Jabbar, A., Gupta, R ., Sidhu, G. 2020. Three metachronous primary lung cancers in a chronic smoker. Medicine, 50 (e22559) doi: 10.1097/MD.0000000000022559.

• Kroemer A, Khan K, Plassmeyer M, Alpan, O., Haseeb, MA., Gupta, R., Fishbein, TM. 2020. Inflammasome activation and pyroptosis in lymphopenic liver patients with COVID-19. Journal of Hepatology, DOI: 10.1016/j.jhep.2020.06.034.

• Awasthi, S., Berglund, A., Abraham-Miranda, J., Rounbehler, R., Kensler, K., Serna, A., Vidal, AC., You, S., Freeman, M., Davicioni, E., Liu, Y., Karnes, J., Klein, E., Den, R., Trock, B., Campbell, J., Einstein, D., Gupta, R., Balk, S., Lal, P., Park, J., Cleveland, J., Rebbeck, T., Freedland, S., Yamoah, K. 2020. Comparative genomics reveals distinct immune-oncologic pathways in African American men with prostate cancer. Clinical Cancer Research,1;27(1):320-329. doi: 10.1158/1078-0432.CCR-20-2925. PMID: 33037017; PMCID: PMC8042600.

• Dogan, M., Kozhaya, L., Placek, L., Gunter, C., Yigit, M., Hardy, R., Plassmeyer, M., Coatney, P., Lillard, K., Bukhari, Z., Kleinberg, M., Hayes, C., Arditi, M., Klapper, E., Merin, N., Liang, BT., Gupta, R.,  Alpan, O., Unutmaz, D. 2020. Novel SARS-CoV-2 specific antibody and neutralization assays reveal wide range of humoral immune response during COVID-19. Communications Biology, 4(1). https://doi.org/10.1038/s42003-021-01649-6

• Paredes, J., Zabaleta, J., Garai, J., Ping, J., Imtiaz,S., Spagnardi, M., Alvarado, J., Li, L., Akadri, M., Barrera, K., Munoz-Sagastibelza, M., Gupta, R., Alshal, M., Talus, H., Wang, X., Carethers, JM., Williams, J., Martello, LA. 2020. Immune-Related Gene Expression and Cytokine Secretion is Reduced Among African American Colon Cancer Patients. Frontiers in Oncology, 10:1498. doi: 10.3389/fonc.2020.01498. PMID: 32983990; PMCID: PMC7492388.

• Wang, WW., Sorokin, I., Aleksic, I., Fisher.H., Kaufman,R., Winer, A., McNeill, B., Gupta, R.,Tilki, D., Fleshner, N., Klotz, L., DiRienzo, AG.,Tenniswood, M. 2020. Expression of Small Non-coding RNAs in Urinary Exosomes Classifies Prostate Cancer into Indolent and Aggressive Disease. J Urol, PMID: 32191585. DOI:10.1097/JU.0000000000001020.

• Momeni-Boroujeni, A., Yousefi, E.,Haseeb, M.A., Gupta, R. 2020. Computer - assisted Diagnosis of Breast Cancer by Cell Network Matrix Extraction and Multilayer Perceptron Analysis. Annals of Clinical & Laboratory Science, 50 (2).

• Xia, R., Momeni-Boroujeni, A., Shea, S., Pan, Y, Agrawal, R., Yousefi, E., Haseeb, M.A,. Gupta, R. 2019. Diagnosis of Liver Neoplasms by Computational and Statistical Image Analysis. Gastroenterology Research, 12(6). doi: https://doi.org/10.14740/gr1210

• Isaac, J., Pereda, M., Gupta, R., Zhang, Y., Jyakumar, R., Miller, S. Massive Splenic Infarction in a Child with Sickle Cell Disease on Chronic Transfusion Therapy. 2018. Journal of Pediatric Hematology/Oncology, 41(2). PMID: 30499910 DOI: 10.1097/MPH.0000000000001356

• Laskar, D., Rose, M., Gupta, R., Tanowitz, H., Haseeb, MA. 2018. Monoclonal Gammopathy of Undetermined Significance is Associated with Loa loa Infection. American Journal of Tropical Medicine & Hygiene. [Epub ahead of print]. PMID: 30203743. doi: 10.4269/ajtmh.18-0351.
• Sadaf, S., Schwarz, S., Anderson, V., Gupta, R., Heidarian, A., Rabinovitz, S. 2018. Pediatric Helicobacter pylori gastropathy demonstrates a unique pattern of gastric foveolar hyperplasia. Helicobacter. 23(3):e12487. doi: 10.1111/hel.12487.
• Mascareno, E., Gupta, R., Martello, LA., Dhar-Mascareno, M., Salciccioli, L., Beckles, D., Walsh, MG.,  Machado, FS., Tanowitz, HB., Haseeb,M.A. 2017. Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible-1 (Hexim-1) gene. Microbes & Infection. 20(1):25-36. doi: 10.1016. PMID: 28951318.
• Gupta, R., Haseeb, M.A. 2017. Path to the future: Join hands with your fellow pathologists - make your community stronger. Archives of Pathology and Laboratory Medicine.141(12):1602-1603. doi: 10.5858. PMID: 29189066.
• Azhar, M., Shafique, K., Oza, T., M.A. Haseeb., Gupta, R. Bilateral thyroid-type struma ovarii in a postmenopausal patient: A case report and review of literature. 2017. Journal of Clinical Gynecology and Obstetrics. [in press].
• Shah S, Gupta R, Shinder R. Orbital Plasmacytoma in a Young Man with Multiple Myeloma. 2017. J Clin Exp Ophthalmol. [in press]
• Gottesman, S., Yousefi, E., Gupta, R. Hydrophilic polymer vasculopathy with coinciding pseudoxanthoma elasticum-like changes in an amputated toe. 2017. Journal of Cutaneous Pathology. doi:10.1111/cup.12889.
• Arora, S., Levitan, D; Regmi, N; Sidhu, G; Gupta, R; Nicastri, A; Saggi, SJ; Braverman, A. Cryoglobulinemia in a patient with Chronic Lymphocytic Leukemia (CLL) - A case report and review of literature of renal involvement in CLL. 2016. Blood Cells, Molecules and Diseases. 60: 7-11. doi:10.1016.
• Silverman, N., Lanjewar, S, Gupta, R., Shinder, R. 2016. IgG4-related disease of the punctum and canaliculus. Ophthalmic Plastic and Reconstructive Surgery. PMID: 26866331 [Epub ahead of print]
• Ayoub, I., Babinska, A., Gupta, R., Oh, M., Salifu, M. 2015. Colon necrosis due to sodium polystyrene sulfonate (SPS) with and without sorbitol: An experimental study in rats. PLoS One. 28;10(9). PMID: 26413782.
• Gupta, R., Gorsky, M., Henderson, T., & M.A. Haseeb. 2015. Clinical course of unilateral Acanthamoeba keratitis in a cosmetic contact lens wearer. Annals of Clinical & Laboratory Science, 45: 366-370. PMID: 26116606
• Loizou, D., Enav, B., Komlodi-Pasztor, E., Hider, P., Kim-Chang, J., Noonan, L., Taber, T., Kaushal, S., Limgala, R., Brown, M., Gupta, R., Balba, N., Goker-Alpan, O., Khojah, A. & Alpan, O. 2015. The effect of omalizumab treatment on allergic tissue inflammation and clinical outcomes in patients with eosinophilic esophagitis: An open label, single arm study. PLoS One, 10 (3). PMID: 25789989
• Kinneman, L., Molloy, B., Nguyen, V., Loizou, D., Silverman, R., Mensah-Bonsu, N., Enav, B., Johal, J., Plassmeyer, M., Ryherd, M., Austin, L., Limgala, R., Brown, M., Gupta, R., Noonan, L., Hider, P. & Alpan, O. 2014. Diffuse cutaneous mastocytosis, bullous variant, presenting in a six-month-old infant. Journal of Allergy and Clinical Immunology in Practice, 2: 341-342. PMID: 24811027
• Xi, Q., Wang, H., Heilman, E.R., Walsh, M.G., Haseeb, M.A. & Gupta, R. 2014. Increased expression of enhancer of Zeste homolog 2 (EZH2) differentiates squamous cell carcinoma from normal skin and actinic keratosis. European Journal of Dermatology, 24: 41-45. PMID: 24413452
• Gill, R., Al-Subu, A., Elitsur, Y., Gupta, R., Treem, W.R., Rabinowitz, S. & Schwarz, S.M. 2014. Eosinophilic esophagitis in two ethnically distinct pediatric populations. Journal of Allergy and Clinical Immunology, 133: 576–577.
• Martello, L.A., Wadgaonkar, R., Gupta, R., Machado, F.S., Walsh, M.G., Mascareno, E., Tanowitz, H.B. & Haseeb, M.A. 2013. Characterization of Trypanosoma cruzi infectivity, proliferation, and cytokine patterns in gut and pancreatic epithelial cells maintained in vitro. Parasitology Research, 112: 4177-4183. PMID: 24018709.
• Rets, A., Gupta, R. & Haseeb, M.A. 2013. Determinants of reactivation of inapparent Strongyloides stercoralis infection in patients hospitalized for unrelated admitting diagnosis. European Journal of Gastroenterology and Hepatology, 25: 1279-1285. PMID: 24081104.
• Huimiao, J., Gupta, R. & Somma, J. 2013. EZH2, a unique marker of malignancy in effusion cytology. Diagnostic Cytopathology, 42: 111-116. PMID: 23636867.
• Gupta, R., Babb, J.S., Singh, B., Chiriboga, L., Libbys, L., Adams, S. & Demaria, S. 2011. The numbers of FoxP3+ lymphocytes in sentinel lymph nodes of breast cancer patients correlate with primary tumor size but not nodal status. Cancer Investigation, 29: 419-425. PMID: 21649468.
• Lim, R.P., Tuvia, K., Hajdu, C.H., Losada, M., Gupta, R., Parikh, T., Babb, J.S. & Taouli, B. 2010. Quantification of hepatic iron deposition in patients with liver disease: comparison of chemical shift imaging with single-echo T2-weighted imaging. American Journal of Roentgenology, 194: 1288-1295. PMID: 20410416.
• Zhang, X., Gupta, R. & Nicastri, A.D. 2010. Bladder adenocarcinoma following gastrocystoplasty. Journal of Pediatric Urology, 6: 525-527. PMID: 2039267.
• Hyams, E.S., Gupta, R., Melamed, J., Taneja, S.S. & Shah, O. 2009. Renal involvement by chronic myelomonocytic leukemia requiring nephrouretrectomy. Reviews in Urology, 11: 33–37. PMID: 19390673.
• Gupta, R., Soupir, C.P., Johari, V. & Hasserjian, R.P. 2007. Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphologic dysplasia and frequent thrombocytopenic presentation. British Journal of Haematology, 139: 265-268. PMID: 17764468.
• Olack, B., Gupta, R. & Brooks, G.S. 2007. Anaplastic large T-cell lymphoma arising in saline breast implant capsule after tissue expander breast reconstruction. Annals of Plastic Surgery, 59: 56-57. PMID: 17589261.