Richard Feinman, PhD
Professor
Department of Cell Biology
Principal author of the 26-author comprehensive review,” Dr. Feinman has long been a critic of the current state of medical nutrition and the associated literature. Recent book “The World Turned Upside Down. The Second Low Carbohydrate Revolution” describes “how the science of carbohydrate restriction arising from a rag-tagcollection of popular diets defeated the powerful low-fat army and became the default approach to health.”
The re-emergence of the Warburg effect as a research target in cancer has encouraged exploration of dietary approaches to therapy and prevention. Warburg observed that many cancers exhibit greater glycolytic metabolism even in the presence of oxygen. My current research is part of the program in Ketogenic Diets for Cancer spearheaded by Dr. Eugene J. Fine of Albert Einstein College of Medicine. We ask whether dietary carbohydrate restriction and, in particular, the ketotic state that is generated, can target the disruption in metabolism reflected in the Warburg effect. We found that acetoacetate, one of the ketone bodies, inhibits growth and ATP in several cancer lines grown in culture. Normal fibroblasts are not affected.
Director of the Nutrition & Metabolism Society and former co-Editor-In-Chief (2004-2009) of the online journal, Nutrition&Metabolism
link to journal: http://www.nutritionandmetabolism.com/home/