Patrick Geraghty, PhD

Patrick Geraghty received a bachelor of science degree in 2000, and Ph.D. in Microbiology from the National University of Ireland-Maynooth in 2004. He completed post-doctoral training at the Royal College of Surgeons in Ireland-Dublin and an NIH-funded research fellowship at Columbia University in New York. Dr. Geraghty joined the Division of Pulmonary, Critical Care and Sleep Medicine at St. Luke's Roosevelt Hospital/Mount Sinai West in 2011 as Research Associate. He has been on the faculty at SUNY Downstate since 2015 as Research Assistant Professor. His research activities focus on pulmonary immunology with specific interests in microbial infections in diseased lungs. He has explored the role of phosphatases, pathogen recognition receptors, proteases and phospholipid transporter protein in the regulation of lung disease progression. His work focuses on pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), alpha-1 antitrypsin deficiency and pneumonia. He has over 30 peer reviewed research publications and has research funding from the Alpha-1 Foundation and the Flight Attending's Medical Research Institution.

• Geraghty, P., Hadas, E., Kim, B.-H., Dabo, A.J., Volsky, D.J. and Robert Foronjy, F. HIV infection model of chronic obstructive pulmonary disease in mice. Am J Physiol Lung Cell Mol Physiol. (2017) Jan 19:ajplung.00431.2016. doi: 10.1152/ajplung.00431.2016. [Epub ahead of print]
• Geraghty, P., Baumlin, N., Salathe, M.A., Foronjy, R.F. and D'Armiento, J.M. Glutathione peroxidase-1 suppresses the unfolded protein response upon cigarette smoke exposure. Mediators of Inflammation (2016) 2016;2016:9461289. doi: 10.1155/2016/9461289.
• Garcia-Arcos, I., Geraghty, P., Baumlin, N., Campos, M., Dabo, A.J., Jundi, B., Cummins, N., Eden, E., Grosche, A., Salathe, M. and Foronjy, R. Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner. Thorax. (2016) Aug 24. pii: thoraxjnl-2015-208039. doi: 10.1136/thoraxjnl-2015-208039. [Epub ahead of print]
• Foronjy, R., Salathe, M., Dabo, A.J., Baumlin, N., Cummins, N., Eden, E. and Geraghty, P. TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice. Am J Physiol Lung Cell Mol Physiol. (2016) Jun 10:ajplung.00073.2016. doi: 10.1152/ajplung.00073.2016. [Epub ahead of print]
• Weng, C.H., Gupta, S., Geraghty, P., Foronjy, R. and Pernis, A.B. Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production. Mol Immunol. (2016) Mar;71:115-22. doi: 10.1016/j.molimm.2016.01.013. Epub 2016 Feb 13.
• D'Armiento, J., Shiomi, T., Marks, S., Geraghty, P., Sankarasharma, D. and Chada, K. Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation. Cancer Res. 2016 Feb 2. [Epub ahead of print]
• Foronjy, R.F., Ochieng, P.O., Salathe, M.A., Dabo, A.J., Eden, E., Baumlin, N., Cummins, N., Barik, S., Campos, M., Thorp, E.B. and Geraghty, P. Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations. Mucosal Immunol. (2016) Jan 27. doi: 10.1038/mi.2015.138. [Epub ahead of print]
• Dabo, A.J., Cummins, N., Eden, E. and Geraghty, P. Matrix metalloproteinase 9 exerts antiviral activity against respiratory syncytial virus. PLoS One. (2015) Aug 18;10(8):e0135970. doi: 10.1371/journal.pone.0135970. eCollection 2015.
• Yoo, S., Takikawa, S., Geraghty, P., Argmann, C., Campbell, J., Lin, L., Huang, T., Tu, Z., Foronjy, R., Spira, A., Schadt, E.E., Powell, C.A., Zhu, J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. (2015) Jan 8;11(1):e1004898. doi: 10.1371/journal.pgen.1004898. eCollection 2015 Jan.
• Foronjy, R.F., Taggart, C.C., Dabo, A.J., Weldon, S., Cummins, N. and Geraghty, P. Type I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors. Mucosal Immunol. (2015) Jan;8(1):161-75. doi: 10.1038/mi.2014.54. Epub 2014 Jul 9.
• Geraghty, P., Eden, E., Pillai, M., Campos, M., McElvaney, N.G. and Foronjy, R.F. α-1 antitrypsin activates protein phosphatase 2A (PP2A) to counter lung inflammatory responses. Am J Respir Crit Care Med. (2014) Dec 1;190(11):1229-42. doi: 10.1164/rccm.201405-0872OC.
• Foronjy, R.F., Dabo, A.J., Cummins, N. and Geraghty, P. Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection. BMC Immunology (2014) 2014 Oct 3;15(1):41.
• Brehm, A., Geraghty, P., Campos, M. Gaffney, A., Eden, E., Jiang, X.C., D'Armiento, J.M. and Foronjy, R.F. Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation. FASEB J. 2014 Feb 28;9(2):e90567. doi: 10.1371/journal.pone.0090567.
• Foronjy, R.F., Taggart, C.C., Dabo, A.J., Weldon, S. and Geraghty, P. Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice. PLoS One. (2014) Feb 28;9(2):e90567. doi: 10.1371/journal.pone.0090567. eCollection 2014.
• Geraghty, P., Hardigan, A. and Foronjy, R.F. Cigarette smoke activates the proto-oncogene c-Src to promote airway inflammation and lung tissue destruction. Am. J. Respir. Cell Mol. Biol., (2014) 2014 Mar;50(3):559-70. doi: 10.1165/rcmb.2013-0258OC.
• Geraghty, P., Wyman, A.E., Garcia-Arcos, I., Dabo, A.J., Gadhvi, S. and Foronjy, R. STAT3 Modulates Cigarette Smoke-Induced Inflammation and Protease Expression. Front. Physiol. (2013) doi: 10.3389/fphys.2013.00267
• Reeves, E.P., Banville, N., Ryan, D.M., O'Reilly, N., Bergin, D.A., Pohl, K., Molloy, K., McElvaney, O.J., Alsaleh, K., Aljorfi, A., Kandalaft, O., O'Flynn, E., Geraghty, P., O'Neill, S.J. and McElvaney, N.G. Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease. Biomed Res Int. (2013) doi: 10.1155/2013/560141.
• Geraghty, P. and Foronjy, R. Protein transfection of mouse lung. J Vis Exp. (2013) May 15;(75). doi: 10.3791/50080.
• Geraghty, P., Hardigan, A., Wallace, A.M., Mirochnitchenko, O., Thankachen, J., Arellanos, L., Thompson, V., D'Armiento, J.M. and Foronjy, R.F. The GPx1-PTP1B-PP2A axis: a key determinant of airway inflammation and alveolar destruction. Am J Respir Cell Mol Biol. (2013) Nov;49(5):721-30. doi: 10.1165/rcmb.2013-0026OC.
• D'Armiento, J., Goldklang, M., Hardigan, A.A., Geraghty, P., Roth, M., Connett, J., Wise, R., Sciurba, F., Scharf, S., Thankachen, J., Islam, M., Ghio, A. and Foronjy, R. Increased Matrix Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema. PLoS One. (2013) 8(2):e56352. doi: 10.1371/journal.pone.0056352. Epub (2013) Feb 18.
• Mehra, D., Geraghty, P., Hardigan, A.A., Foronjy, R. A comparison of the inflammatory and proteolytic effects of dung biomass and cigarette smoke exposure in the lung. PLoS One. (2012) 7(12):e52889. doi: 10.1371/journal.pone.0052889. Epub (2012) Dec 20.
• Wallace, A.M., Hardigan, A., Geraghty, P., Salim, S., Gaffney, A., Thankachen, J., Arellanos, L., D Armiento, J.M. and Robert F. Foronjy. Protein phosphatase 2A (PP2A) regulates innate immune and proteolytic responses to cigarette smoke exposure in the lung. Toxicol Sci. (2012) 126(2): 589-99.
• Geraghty, P., Dabo, A.J. and D'Armiento, J. TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease. J Biol Chem. (2011) 286 (34): 30211-8.
• Geraghty, P., Wallace, A. and D'Armiento, J. Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process. Int J Chron Obstruct Pulmon Dis. (2011);6:309-19.
• Bergin, D.A., Greene, C.M., Sterchi, E.E., Kenna, C., Geraghty, P., Taggart, C.C, O'Neill, S.J., McElvaney, N.G. Activation of EGFR by a novel metalloprotease pathway. J Biol Chem. (2008) 283(46): 31736-44.
• Geraghty, P., Rogan, M.P., Greene, C.M., Brantly, M., O'Neill, S.J., Taggart, C.C., McElvaney, N.G. Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro. Thorax (2008) 63 (7) 621-6.
• Geraghty, P., Greene, C.M., O'Mahony, M., O'Neill, S.J., Taggart, C.C., McElvaney, N.G. Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression. J Biol Chem. (2007) 282 (46) 33389-95.
• Geraghty, P., Rogan, M.P., Catherine M. Greene, Boxio, R.M.M., Poiriert, T., O'Mahony, M., Belaaouaj, A., O'Neill, S.J., Taggart, C.C. and McElvaney, N.G. Neutrophil elastase upregulates Cathepsin B and Metalloprotease-2 expression. J Immunol. (2007) 178 (9) 5871-86.
• Geraghty, P. and Kavanagh, K. Disruption of mitochondrial function in Candida albicans leads to reduced cellular ergosterol levels and elevated growth in the presence of amphotericin B. Arch Microbiol (2003) 179: 295-300.
• Geraghty, P. and Kavanagh, K. Erythromycin, an inhibitor of mitoribosomal protein biosynthesis, alters the amphotericin B susceptibility of Candida albicans. J Phar Pharmacology (2003) 55: 179-184

Review Article:

• Rogan, M.P., Geraghty, P., Greene, C.M., O'Neill, S.J., Taggart, C.C. and McElvaney, N.G. Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir Res. (2006) 17: 17-29.

Book Chapters:

• Geraghty, P. and Foronjy, F. (2017) Smoke Exposure Models in COPD. Chapter 57A in Critical care. Publishers: McGraw-Hill Education. Editors: Oropello, J.M., Pastores, S.M. and Kvetan, V. Available Online
• Geraghty, P. and Kavanagh, K. (2006) Extraction and Detection of DNA and RNA from Yeast. Chapter 8 (pp159-179) in Medical Mycology: Cellular and Molecular Techniques. Publishers: Wiley & Co. Ltd. Chichester, UK (ISBN: 0-470-01923-9 hardback) Edit: K. Kavanagh.