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SUNY Downstate Health Sciences University

Department of Psychiatry & Behavioral Sciences

Profile

Chella Kmarajan, PhD

Chella Kamarajan, PhD

Assistant Professor

Tel: (718) 270-2913

e-mail: chella.kamarajan@downstate.edu

Dr. Kamarajan is a clinical- and neuro-psychologist and a neuroscientist by education and training, and he has clinical and/or research expertise in multiple domains, viz., brain electrophysiology, neuropsychology, neuroimaging, computational programming, signal/image processing and statistics, assessments and therapeutics in addiction and mental disorders. He has over 24 years of experience in brain electrophysiology, including 18 years in the Henri Begleiter Neurodynamics Laboratory (HBNL), where he is the Director of Neurophysiology Analysis division and lead various analysis efforts related to neural oscillatory mechanisms underlying risk and consequences of substance use disorders (SUD) using datasets from various research projects at the HBNL. He has been a member of Neurophysiology and Translational Committees as well as a Co-Investigator in the Collaborative Study on the Genetics of Alcoholism (COGA). He is also the course director of an elective “Neurophysiology of Alcohol and Drug Addiction” for the final year medical students. He has been serving as a co-investigator in NIH-funded projects (past and ongoing studies). Dr. Kamarajan has published several important research and review papers on neurophysiological abnormalities in AUD and its risk. In recent years, he has organized and presented at various symposia on neurophysiology of AUD during scientific meetings. He has been an active reviewer and on the editorial boards of several journals, and he is currently editing special issues on topics related to neuroscience of alcoholism. He has evaluated several PhD dissertations as an expert examiner in topics related to neurophysiology, neuropsychology, psychopathology, and mental health research. Dr. Kamarajan has also been involved in teaching, training and mentoring medical and graduate students, postdoctoral researchers, and psychiatry residents in SUNY DHSU. Recently, he has extended his focus on the neurophysiological aspects of other substance use disorders with a specific emphasis on concurrent use of multiple substances in adolescents and young adults using data from the COGA Prospective study. In addition to ERP and ERO measures during cognitive tasks, he has been focusing on other specific measures related to phase synchrony (e.g., phase-locking index, inter-trial phase coherence and inter-site phase synchrony) and network properties (Granger causality and Graph theory) by examining various brain connectivity methods implemented using both sensor space (i.e., scalp electrodes) and source space (e.g., MNE, eLORETA). His work is at the interface between basic science and clinical applications in substance use disorders, and has a strong potential for translational implications to treat alcohol and drug addictions.

Education / Training / Employment
  • 2013 - Now  — Assistant Professor (tenure-track), Department of Psychiatry, SUNY Downstate Health Sciences University, NY
  • 2004 - 2013 — Research Scientist, Henri Begleiter Neurodynamics Lab, SUNY Downstate Health Sciences University, NY
  • 2002 - 2004 — Postdoctoral Research Fellow, Henri Begleiter Neurodynamics Lab, SUNY Downstate Health Sciences University, NY
  • 2000 - 2002 — Postdoctoral Clinical Fellow, National Institute of Mental Health and Neurosciences, Bangalore, India
  • 1996 - 2001 — Ph.D. (Clinical Psychology), National Institute of Mental Health and Neurosciences, Bangalore, India (Dissertation:  "Psychophysiological Correlates of Hypnosis in Functional Mental Disorders")
  • 1994 - 1996 — M.Phil. (Medical and Social Psychology), Central Institute of Psychiatry, Ranchi, India (Dissertation: "Premorbid Personality and Life Events in Functional Mental Disorders: Toward Evolving a Causal Model")
  • 1993 - 1994 — Research Assistant, Department of Psychiatry, Christian Medical College, Vellore, India
  • 1991 - 1993 — M.A. (Psychology), Annamalai University, Tamil Nadu, India
  • 1988 - 1991 — B.A. (English Literature), Thiagarajar College, Madurai Kamaraj University, Madurai, India
  • Meyers JL, Zhang J, Chorlian D, Pandey A, Kamarajan C, Kinreich S, Wang JC, Chao M, Kapoor M, Wetherill L, Lai D, Bertelsen S, McClintick J, Bauer L, Hesselbrock V, Kuperman S, Kramer J, Salvatore JE, Agrawal A, Edenberg HJ, Foroud T, Goate A, Porjesz B (2020-in press) A genome wide association study of interhemispheric theta EEG coherence: Implications for neural connectivity and alcohol use behavior in families of European and African ancestry. Molecular Psychiatry.
  • Barr PB, Ksinan A, Su J, Johnson EC, Meyers JL, Wetherill L, Latvala A, Aliev F, Chan G, Kuperman S, Nurnberger J, Kamarajan C, Anokhin A, Agrawal A, Rose RJ, Edenberg HJ, Schuckit M, Kaprio J, Dick DM (2020-in press) Using Polygenic Scores for Identifying Individuals at Increased Risk of Substance Use Disorders in Clinical and Population Samples. Translational Psychiatry.
  • Kamarajan C, Ardekani BA, Pandey AK, Chorlian DB, Kinreich S, Pandey G, Meyers JL, Zhang J, Kuang W, Stimus AT, Porjesz B (2020) Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures. Behavioral Sciences, 10:62. PMID: 32121585.
  • Kamarajan C, Ardekani BA, Pandey AK, Kinreich S, Pandey G, Chorlian DB, Meyers JL, Zhang J, Bermudez E, Stimus AT, Porjesz B (2020) Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures. Brain Sciences, 10:115.  PMID: 32093319.
  • Pandey G, Seay MJ, Meyers JL, Chorlian DB, Pandey AK, Kamarajan C, Ehrenberg M, Pitti D, Kinreich S, Subbie-Saenz de Viteri S, Acion L, Anokhin A, Bauer L, Chan G, Edenberg H, Hesselbrock V, Kuperman S, McCutcheon VV, Bucholz KK, Schuckit M, Porjesz B (2020) Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity. Alcoholism: Clinical and Experimental Research.  PMID: 31957047.
  • Bourdon JL, Tillman R, Francis MW, Dick DM, Stephenson M, Kamarajan C, Edenberg HJ, Kramer J, Kuperman S, Bucholz KK, McCutcheon VV (2020) Characterization of Service Use for Alcohol Problems Across Generations and Sex in Adults With Alcohol Use Disorder. Alcoholism: Clinical and Experimental Research.  PMID: 31984526.
  • Kinreich S, Meyers JL, Maron-Katz A, Kamarajan C, Pandey AK, Chorlian DB, Zhang J, Pandey G, Subbie-Saenz de Viteri S, Pitti D, Anokhin AP, Bauer L, Hesselbrock V, Schuckit MA, Edenberg HJ, Porjesz B (2019) Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study. Molecular Psychiatry. PMID: 31595034.
  • Wetherill L, Lai D, Johnson EC, Anokhin A, Bauer L, Bucholz KK, Dick DM, Hariri AR, Hesselbrock V, Kamarajan C, Kramer J, Kuperman S, Meyers JL, Nurnberger JI, Jr., Schuckit M, Scott DM, Taylor RE, Tischfield J, Porjesz B, Goate AM, Edenberg HJ, Foroud T, Bogdan R, Agrawal A (2019) Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans. Genes, Brain and Behavior. 18: PMID: 31099175.
  • Lai D, Wetherill L, Bertelsen S, Carey CE, Kamarajan C, Kapoor M, Meyers JL, Anokhin AP, Bennett DA, Bucholz KK, Chang KK, De Jager PL, Dick DM, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI, Jr., Raj T, Schuckit M, Scott DM, Taylor RE, Tischfield J, Hariri AR, Edenberg HJ, Agrawal A, Bogdan R, Porjesz B, Goate AM, Foroud T (2019) Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria. Genes, Brain and Behavior. 18: PMID: 31090166.
  • Mukundan CR, Kamarajan C, Ajayan P (2019) Live and die - develop a mind within, while living, using which one learns to create ideas, functional systems, and knowledge; and die later, when the mind ceases to be present. Journal of Psychology and Clinical Psychiatry, 10:234‒239.
  • Mukundan CR, Kamarajan C, Ajayan P (2019) Mind in the brain - creation of the greatest virtual world. Journal of Psychology and Clinical Psychiatry. 10:83-90.
  • Meyers JL, Chorlian DB, Johnson EC, Pandey AK, Kamarajan C, Salvatore JE, Aliev F, Subbie-Saenz de Viteri S, Zhang J, Chao M, Kapoor M, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Tischfield J, Goate A, Foroud T, Dick DM, Edenberg HJ, Agrawal A, Porjesz B (2019) Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. Brain Sciences, 9. PMID: 31627376.
  • Meyers J, McCutcheon VV, Pandey AK, Kamarajan C, Subbie S, Chorlian D, Salvatore J, Pandey G, Almasy L, Anokhin A, Bauer L, Bender A, Dick DM, Edenberg HJ, Hesselbrock V, Kramer J, Kuperman S, Agrawal A, Bucholz K, Porjesz B (2019) Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task. Journal of the American Academy of Child and Adolescent Psychiatry. 58:242-255 e242. PMID: 30738551.
  • Pandey AK, Ardekani BA, Kamarajan C, Zhang J, Chorlian DB, Byrne KN, Pandey G, Meyers JL, Kinreich S, Stimus A, Porjesz B (2018) Lower Prefrontal and Hippocampal Volume and Diffusion Tensor Imaging Differences Reflect Structural and Functional Abnormalities in Abstinent Individuals with Alcohol Use Disorder. Alcoholism: Clinical and Experimental Research. 42:1883-1896. PMID: 30118142.
  • Meyers JL, Zhang J, Wang JC, Su J, Kuo SI, Kapoor M, Wetherill L, Bertelsen S, Lai D, Salvatore JE, Kamarajan C, Chorlian D, Agrawal A, Almasy L, Bauer L, Bucholz KK, Chan G, Hesselbrock V, Koganti L, Kramer J, Kuperman S, Manz N, Pandey A, Seay M, Scott D, Taylor RE, Dick DM, Edenberg HJ, Goate A, Foroud T, Porjesz B (2017) An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. Molecular Psychiatry, 22(12):1767-1775. PMID: 28070124.
  • Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Edenberg HJ, Wetherill L, Schuckit M, Wang JC, Kuperman S, Kramer J, Tischfield JA, Porjesz B (2017) A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. International Journal of Psychophysiology, 115:13-23. PMID: 27993610.
  • Chorlian DB, Rangaswamy M, Manz N, Meyers JL, Kang SJ, Kamarajan C, Pandey AK, Wang JC, Wetherill L, Edenberg H, Porjesz B (2017) Genetic correlates of the development of theta event related oscillations in adolescents and young adults. International Journal of Psychophysiology, 115:24-39. PMID: 27847216.
  • Meyers JL, Zhang J, Manz N, Rangaswamy M, Kamarajan C, Wetherill L, Chorlian DB, Kang SJ, Bauer L, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI, Jr., Tischfield J, Wang JC, Edenberg HJ, Goate A, Foroud T, Porjesz B (2017) A genome wide association study of fast beta EEG in families of European ancestry. International Journal of Psychophysiology, 115:74-85. PMID: 28040410.
  • Pandey AK, Kamarajan C, Manz N, Chorlian DB, Stimus A, Porjesz B (2016) Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65:158-171. PMID: 26456730.
  • Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Anokhin AP, Bauer LO, Kuperman S, Kramer J, Bucholz KK, Schuckit MA, Hesselbrock VM, Porjesz B (2015) Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. PLoS One, 10:e0142659.
  • Chorlian DB, Rangaswamy M, Manz N, Kamarajan C, Pandey AK, Edenberg H, Kuperman S, Porjesz B (2015) Gender modulates the development of theta event related oscillations in adolescents and young adults. Behavioural Brain Research, 292(1):342-352. PMID: 26102560.
  • Kamarajan C, Pandey AK, Chorlian DB, Manz N, Stimus AT, Bauer LO, Hesselbrock VM, Schuckit MA, Kuperman S, Kramer J, Porjesz B (2015) Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. International Journal of Psychophysiology, 98(2):182-200. PMID: 26388585.
  • Kamarajan C, Pandey AK, Chorlian DB, Porjesz B (2015) The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. International Journal of Psychophysiology, 97(3):310-322. PMID: 25448264.
  • Kamarajan C, Porjesz B (2015) Advances in Electrophysiological Research. Alcohol Research: Current Reviews, 37(1):53-87. PMID: 26259089.
  • Mukundan CR, Kamarajan C, Ajayan P, Roopesh BN, Sharma M (2013) The frontal cortex and recognition: Neurocognitive findings of hypnosis. Indian Journal of Health and Wellbeing, 4(4):703-710.
  • Kamarajan C, Porjesz B (2012) Brain waves in Impulsivity Spectrum Disorders, in Psychology of Impulsivity, Cyders MA (ed), 20-93, Nova Science Publishers, Hauppauge, NY.
  • Kamarajan C, Rangaswamy M, Manz N, Chorlian DB, Pandey AK, Roopesh BN, Porjesz B (2012) Topography, power, and current source density of theta oscillations during reward processing as markers for alcohol dependence. Human Brain Mapping, 33(5):1019-1039. PMID: 21520344.
  • Pandey AK, Kamarajan C, Rangaswamy M, Porjesz B (2012a) Event-Related Oscillations in Alcoholism Research: A Review. Journal of Addiction Research & Therapy, Suppl 7(1):1-13. PMID: 24273686.
  • Pandey AK, Kamarajan C, Tang Y, Chorlian DB, Roopesh BN, Manz N, Stimus A, Rangaswamy M, Porjesz B (2012b) Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. Biological Psychology, 89(1):170-182. PMID: 22024409.
  • Rao NR, Kodali R, Mian A, Ramtekkar U, Kamarajan C, Jibson MD (2012) Psychiatric residents' attitudes toward and experiences with the clinical-skills verification process: a pilot study on U.S. and international medical graduates. Academic Psychiatry, 36(4):316-322. PMID: 22851030.
  • Garrett M, Singh A, Amanbekova D, Kamarajan C (2011) Lack of insight and conceptions of “mental illness” in schizophrenia, assessed in the third person through case vignettes. Psychosis, 3(2):115-125.
  • Kamarajan C, Rangaswamy M, Tang Y, Chorlian DB, Pandey AK, Roopesh BN, Manz N, Saunders R, Stimus AT, Porjesz B (2010) Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. Journal of Psychiatric Research, 44(9):576-590. PMID: 20035952.
  • Roopesh BN, Rangaswamy M, Kamarajan C, Chorlian DB, Pandey AK, Porjesz B (2010) Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm. Alcoholism: Clinical and Experimental Research, 34(11):1905-1914. PMID: 20659074.
  • Kamarajan C, Porjesz B, Rangaswamy M, Tang Y, Chorlian DB, Padmanabhapillai A, Saunders R, Pandey AK, Roopesh BN, Manz N, Stimus AT, Begleiter H (2009) Brain signatures of monetary loss and gain: outcome-related potentials in a single outcome gambling task. Behavioural Brain Research, 197(1):62-76. PMID: 18775749.
  • Roopesh BN, Rangaswamy M, Kamarajan C, Chorlian DB, Stimus A, Bauer LO, Rohrbaugh J, O'Connor SJ, Kuperman S, Schuckit M, Porjesz B (2009) Priming deficiency in male subjects at risk for alcoholism: the N4 during a lexical decision task. Alcoholism: Clinical and Experimental Research, 33(12):2027-2036. PMID: 19764939.
  • Kamarajan C, Rangaswamy M, Chorlian DB, Manz N, Tang Y, Pandey AK, Roopesh BN, Stimus AT, Porjesz B (2008) Theta oscillations during the processing of monetary loss and gain: a perspective on gender and impulsivity. Brain Research, 1235:45-62. PMID: 18616934.
  • Chen AC, Porjesz B, Rangaswamy M, Kamarajan C, Tang Y, Jones KA, Chorlian DB, Stimus AT, Begleiter H (2007) Reduced frontal lobe activity in subjects with high impulsivity and alcoholism. Alcoholism: Clinical and Experimental Research, 31(1):156-165. PMID: 17207114.
  • Rangaswamy M, Jones KA, Porjesz B, Chorlian DB, Padmanabhapillai A, Kamarajan C, Kuperman S, Rohrbaugh J, O'Connor SJ, Bauer LO, Schuckit MA, Begleiter H (2007) Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. International Journal of Psychophysiology, 63(1):3-15. PMID: 17129626.
  • Jones KA, Porjesz B, Chorlian D, Rangaswamy M, Kamarajan C, Padmanabhapillai A, Stimus A, Begleiter H (2006) S-transform time-frequency analysis of P300 reveals deficits in individuals diagnosed with alcoholism. Clinical Neurophysiology, 117(10):2128-2143. PMID: 16926113.
  • Kamarajan C, Porjesz B, Jones K, Chorlian D, Padmanabhapillai A, Rangaswamy M, Stimus A, Begleiter H (2006) Event-related oscillations in offspring of alcoholics: neurocognitive disinhibition as a risk for alcoholism. Biological Psychiatry, 59(7):625-634. PMID: 16213472.
  • Padmanabhapillai A, Porjesz B, Ranganathan M, Jones KA, Chorlian DB, Tang Y, Kamarajan C, Rangaswamy M, Stimus A, Begleiter H (2006) Suppression of early evoked gamma band response in male alcoholics during a visual oddball task. International Journal of Psychophysiology, 60(1):15-26. PMID: 16019097.
  • Padmanabhapillai A, Tang Y, Ranganathan M, Rangaswamy M, Jones KA, Chorlian DB, Kamarajan C, Stimus A, Kuperman S, Rohrbaugh J, O'Connor SJ, Bauer LO, Schuckit MA, Begleiter H, Porjesz B (2006) Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. International Journal of Psychophysiology, 62(2):262-271. PMID: 16887227.
  • Kamarajan C, Porjesz B, Jones KA, Choi K, Chorlian DB, Padmanabhapillai A, Rangaswamy M, Stimus AT, Begleiter H (2005) Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task. Biological Psychology, 69(3):353-373. PMID: 15925035.
  • Kamarajan C, Porjesz B, Jones KA, Chorlian DB, Padmanabhapillai A, Rangaswamy M, Stimus AT, Begleiter H (2005) Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. Clinical Neurophysiology, 116(5):1049-1061. PMID: 15826845.
  • Porjesz B, Rangaswamy M, Kamarajan C, Jones KA, Padmanabhapillai A, Begleiter H (2005) The utility of neurophysiological markers in the study of alcoholism. Clinical Neurophysiology, 116(5):993-1018. PMID: 15826840.
  • Kamarajan C, Porjesz B, Jones KA, Choi K, Chorlian DB, Padmanabhapillai A, Rangaswamy M, Stimus AT, Begleiter H (2004) The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. International Journal of Psychophysiology, 51(2):155-180. PMID: 14693365.
  • Mukundan CR, Ramachandra S, Singh N, Sharma M, Kamarajan C (1999) Brain mechanisms of hypnosis: P300 studies. Indian Journal of Clinical Psychology, 26(1):13-23.

 

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