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SUNY Downstate Medical Center

Division of Infectious Diseases


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Brian R. Edlin, MD

Professor of Medicine

Tel: (718) 804-7804 • Fax: (718) 804-7806


Mailing Address:
450 Clarkson Ave, Box 1240
Brooklyn, NY 11203

Research Interests:
  • Clinical and community-based epidemiology of hepatitis C, its pathogenesis, treatment and prevention.
  • Epidemiological, clinical, virologic and immunologic characteristics of acute hepatitis C virus infection in injection drug users, correlates of immunity against reinfection.
  • Primary and secondary prevention of HIV infection, viral hepatitis, tuberculosis, and other infectious and non-infectious health conditions affecting drug users.
  • Qualitative and quantitative research on social, behavioral, and biological factors affecting the health of persons who inject drugs, and strategies for improving their health.
  • Evaluation of the effectiveness of harm reduction strategies in clinical and community settings, and development of methods to improve their effectiveness.
Current projects:
  1. Swan Project: A study of the clinical, behavioral, virologic, and immunologic characteristics of acute HCV infection among young, high-risk street-recruited injection drug users (IDUs).
  2. Multidisciplinary Integrated Care for Hepatitis C in Substance-Using Persons

Education and Training:
  • 1977 B.A. summa cum laude, University of Pennsylvania, Philadelphia, PA.
  • 1984 MD, Case Western Reserve University, Cleveland, OH.
  • 1984-1987 Residency, Internal Medicine, Baystate Medical Center, Springfield, MA
  • 1987-1989 Fellowship, Infectious Diseases, University of Chicago, IL.
  • 1989-1991 Epidemic Intelligence Service, Centers for Disease Control (CDC), Atlanta, GA.
  • Edlin BR, Irwin KL, Faruque S, McCoy CB, Word C, Serrano Y, Inciardi JA, Bowser BP, Schilling RF, Holmberg SD, Multicenter Crack Cocaine and HIV Infection Study Team. Intersecting epidemics: crack cocaine use and HIV infection among inner-city young adults. N Engl J Med 1994; 331(21):1422-7.
  • Binswanger IA, Kral AH, Bluthenthal RN, Rybold DJ, Edlin BR. Abscesses and cellulitis among injection drug users in San Francisco. Clin Infect Dis 2000; 30:579-81.
  • Bluthenthal RN, Kral AH, Gee L, Erringer EA, Edlin BR. The effect of syringe exchange use on high-risk injection drug users: a cohort study. AIDS 2000; 14:605-11.
  • Kral AH, Lorvick J, Edlin BR. Sex and drug-related risk among populations of younger and older injection drug users in adjacent neighborhoods in San Francisco. J Acquir Immune Defic Syndr 2000; 24:162-7.
  • Murphy EL, DeVita D, Liu H, Vittinghoff E, Leung P, Ciccarone DH, Edlin BR. Risk factors for skin and soft tissue abscess among injection drug users: a case-control study. Clin Infect Dis 2001; 33:35-40.
  • Burris S, Norland J, Edlin BR. Legal aspects of providing naloxone to heroin users in the United States. Int J Drug Policy 2001; 12:237-48.
  • Bluthenthal RN, Kral AH, Gee L, Lorvick J, Moore LD, Seal KH, Edlin BR. Trends in HIV seroprevalence and risk among gay and bisexual men who inject drugs in San Francisco, 1988 to 2000. J Acquir Immune Defic Syndr 2001; 28:264-9.
  • Seal KH, Downing M, Kral AH, Singleton-Banks S, Hammond JP, Lorvick J, Ciccarone D, Edlin BR. Attitudes about prescribing take-home naloxone to injection drug users for the management of heroin overdose: a survey of street-recruited injectors in the San Francisco Bay area. J Urban Health 2003; 80:291-301.
  • Bekker V, Chanock SJ, Yeager M, Hutchinson AA, von Hahn T, Chen S, Xiao N, Dotrang M, Brown M, Busch MP, Edlin BR, Rice CM, O'Brien TR. Genetic variation in CLDN1 and susceptibility to hepatitis C virus infection. J Viral Hepat 2010;17:192-200.
  • Zeremski M, Hooker G, Shu MA, Winkelstein E, Brown Q, Des Jarlais DC, Tobler LH, Rehermann B, Busch MP, Edlin BR, Talal AH. Induction of CXCR3- and CCR5-associated chemokines during acute hepatitis C virus infection. J Hepatol. In press.