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no photo James A. Knowles, MD, PhD

James A. Knowles, MD, PhD

Professor and Chair of Cell Biology
Deputy Director of the Institute for Genomic Health

Education

University of Michigan, Ann Arbor, MI                              B.S. Honors  1980   Molecular Biology

Albert Einstein College of Medicine, Bronx, NY             M.D.-Ph.D.    1987   Genetics

Columbia University/NYSPI, New York, NY                    Residency     1991   Psychiatry

Columbia University/NYSPI, New York, NY                    Post-Doc        1994   Human Genetics

Positions and Employment

1994 – 2001  Assistant Professor of Psychiatry, College of Physicians and Surgeons, Columbia University

2001 – 2006  Associate Professor of Clinical Psychiatry, College of Physicians and Surgeons, Columbia University

2006 – 2017  Professor of Psychiatry/Assoc. Chair of Psychiatry for Research, University of Southern California, Los Angeles, CA

2011 – 2017  Della Martin Chair of Psychiatry & Neuroscience, University of Southern California, Los Angeles, CA

2017 –            Professor and Chairman of Cell Biology, SUNY-Downstate Health Sciences University, Brooklyn, NY

Genetics of Human Disease

I am both a board-certified psychiatrist and a well-established psychiatric geneticist with years of experience in large-scale collaborations. I have cloned the genes for 2 Mendelian disorders, Retinitis Pigmentosa and Primary Pulmonary Hypertension (PPH) (Banerjee et al., 1998; Deng et al., 2000b), but most of my work has been on the genetics of the complex disorders (Schizophrenia, Panic Disorder, Nicotine and Opiate Addiction, Early-Onset Depression and Obsessive-Compulsive Disorder).  All of these projects have now transitioned to using Next Generation DNA Sequencing and I have extensive experience in Whole Genome Sequencing and RNA-Seq.  Much of this RNA-Seq data is publicly available at BrainSpan.org the website for the Transcriptional Atlas of Human Brain Development and resource.psychencode.org for PsychENCODE.

Dr. Knowles is Professor and Chairman of the Department of Cell Biology at SUNY-Downstate Health Sciences University and the Deputy Director of the Genomics Institute at SUNY Downstate. He is both a board-certified psychiatrist and a well-established psychiatric geneticist with years of experience in large-scale collaborations. He discovered the genes for 2 Mendelian disorders, Retinitis Pigmentosa and Primary Pulmonary Hypertension (PPH) (Banerjee et al., 1998; Deng et al., 2000b), but most of his work has been on the genetics of the complex genetic disorders (Schizophrenia, Bipolar Disorder, Early-Onset Depression and Obsessive-Compulsive Disorder). He is the co-leader of the IOCDF-GC, which published the first GWAS of OCD, and a site director of the OCGAS, which published the second OCD GWAS. He is also a Co-Investigator of the Genomic Psychiatry Cohort (GPC, Co-PIs Carlos and Michele Pato), which has collected over 30,000 samples for genetic analyses, principally GWAS. He is also an expert in Next-Generation Sequencing (NGS) and was one of the PIs of the BrainSpan project (www.BrainSpan.org) and the Single Cell Analysis Program (www.SCAP-T.org; NIH Common Fund). His laboratory is also a leader in the analysis of Next Generation Sequencing (NGS) data, and he was one of the co-PIs of the NHGRI funded network to make and distribute software for RNA-Seq analysis (iSeqTools Network, http://iseqtools.org/). He is a member of the PsychENCODE Consortium (www.psychencode.org) and the Whole Genome Sequencing of Psychiatric Disorders consortium (WGSPD).

Dr. Knowles is PI of the NIMH funded GEN-SCRIP Study (GENetics of SChizophRenia In Pakistan), R01MH112904, which is ascertaining and genotyping a large cohort of Pakistani individuals with (n=10,000), and without (n=10,000), schizophrenia. He is also the PI of the NIMH funded GEN-BLIP study (GENetics of BipoLar Disorder In Pakistan) which is ascertaining and genotyping a large cohort of Pakistani individuals with (n=10,000), and without (n=10,000), bipolar disorder.

1.  Aldinger, K.A., Timms, A.E., MacDonald, J.W., McNamara, H.K., Herstein, J.S., Bammler, T.K., Evgrafov, O.V., Knowles, J.A., and Levitt, P. (2020). Transcriptome data of temporal and cingulate cortex in the Rett syndrome brain. Sci Data 7, 192. PMC7305197.

2.  Amare, A.T., Schubert, K.O., Hou, L., Clark, S.R., Papiol, S., Cearns, M., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hsu, Y.H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J.M., Backlund, L., Bhattacharjee, A.K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J.M., Birner, A., Brichant-Petitjean, C., Cervantes, P., Chen, H.C., Chillotti, C., Cichon, S., Cruceanu, C., Czerski, P.M., Dalkner, N., Dayer, A., Del Zompo, M., DePaulo, J.R., Etain, B., Jamain, S., Falkai, P., Forstner, A.J., Frisen, L., Frye, M.A., Fullerton, J.M., Gard, S., Garnham, J.S., Goes, F.S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Herms, S., Hoffmann, P., Hofmann, A., Jimenez, E., Kahn, J.P., Kassem, L., Kuo, P.H., Kato, T., Kelsoe, J.R., Kittel-Schneider, S., Kliwicki, S., Konig, B., Kusumi, I., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S.G., Tortorella, A., Manchia, M., Martinsson, L., McCarthy, M.J., McElroy, S.L., Colom, F., Mitjans, M., Mondimore, F.M., Monteleone, P., Nievergelt, C.M., Nothen, M.M., Novak, T., O'Donovan, C., Ozaki, N., Osby, U., Pfennig, A., Potash, J.B., Reif, A., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., Reininghaus, E., Rouleau, G.A., Rybakowski, J.K., Schalling, M., Schofield, P.R., Schweizer, B.W., Severino, G., Shilling, P.D., Shimoda, K., Simhandl, C., Slaney, C.M., Squassina, A., Stamm, T., Stopkova, P., Maj, M., Turecki, G., Vieta, E., Veeh, J., Witt, S.H., Wright, A., Zandi, P.P., Mitchell, P.B., Bauer, M., Alda, M., Rietschel, M., McMahon, F.J., Schulze, T.G., and Baune, B.T. (2020). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular psychiatry.

3.  Bigdeli, T.B., Genovese, G., Georgakopoulos, P., Meyers, J.L., Peterson, R.E., Iyegbe, C.O., Medeiros, H., Valderrama, J., Achtyes, E.D., Kotov, R., Stahl, E.A., Abbott, C., Azevedo, M.H., Belliveau, R.A., Bevilacqua, E., Bromet, E.J., Byerley, W., Carvalho, C.B., Chapman, S.B., DeLisi, L.E., Dumont, A.L., O'Dushlaine, C., Evgrafov, O.V., Fochtmann, L.J., Gage, D., Kennedy, J.L., Kinkead, B., Macedo, A., Moran, J.L., Morley, C.P., Dewan, M.J., Nemesh, J., Perkins, D.O., Purcell, S.M., Rakofsky, J.J., Scolnick, E.M., Sklar, B.M., Sklar, P., Smoller, J.W., Sullivan, P.F., Macciardi, F., Marder, S.R., Gur, R.C., Gur, R.E., Braff, D.L., Consortium on the Genetics of Schizophrenia, I., Nicolini, H., Escamilla, M.A., Vawter, M.P., Sobell, J.L., Malaspina, D., Lehrer, D.S., Buckley, P.F., Rapaport, M.H., Knowles, J.A., Genomic Psychiatry Cohort, C., Fanous, A.H., Pato, M.T., McCarroll, S.A., and Pato, C.N. (2020). Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry. Molecular psychiatry 25, 2455-2467. PMC7515843.

4.  Coleman, J.R.I., Peyrot, W.J., Purves, K.L., Davis, K.A.S., Rayner, C., Choi, S.W., Hubel, C., Gaspar, H.A., Kan, C., Van der Auwera, S., Adams, M.J., Lyall, D.M., Choi, K.W., on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics, C., Dunn, E.C., Vassos, E., Danese, A., Maughan, B., Grabe, H.J., Lewis, C.M., O'Reilly, P.F., McIntosh, A.M., Smith, D.J., Wray, N.R., Hotopf, M., Eley, T.C., and Breen, G. (2020a). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular psychiatry.

5.  Coleman, J.R.I., Gaspar, H.A., Bryois, J., Bipolar Disorder Working Group of the Psychiatric Genomics, C., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., and Breen, G. (2020b). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological psychiatry 88, 169-184.

6.  Evgrafov, O.V., Armoskus, C., Wrobel, B.B., Spitsyna, V.N., Souaiaia, T., Herstein, J.S., Walker, C.P., Nguyen, J.D., Camarena, A., Weitz, J.R., Kim, J.M.H., Lopez Duarte, E., Wang, K., Simpson, G.M., Sobell, J.L., Medeiros, H., Pato, M.T., Pato, C.N., and Knowles, J.A. (2020). Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia. Biological psychiatry 88, 236-247.

7.  Glanville, K.P., Coleman, J.R.I., Hanscombe, K.B., Euesden, J., Choi, S.W., Purves, K.L., Breen, G., Air, T.M., Andlauer, T.F.M., Baune, B.T., Binder, E.B., Blackwood, D.H.R., Boomsma, D.I., Buttenschon, H.N., Colodro-Conde, L., Dannlowski, U., Direk, N., Dunn, E.C., Forstner, A.J., de Geus, E.J.C., Grabe, H.J., Hamilton, S.P., Jones, I., Jones, L.A., Knowles, J.A., Kutalik, Z., Levinson, D.F., Lewis, G., Lind, P.A., Lucae, S., Magnusson, P.K., McGuffin, P., McIntosh, A.M., Milaneschi, Y., Mors, O., Mostafavi, S., Muller-Myhsok, B., Pedersen, N.L., Penninx, B., Potash, J.B., Preisig, M., Ripke, S., Shi, J., Shyn, S.I., Smoller, J.W., Streit, F., Sullivan, P.F., Tiemeier, H., Uher, R., Van der Auwera, S., Weissman, M.M., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., O'Reilly, P.F., and Lewis, C.M. (2020). Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biological psychiatry 87, 419-430. PMC7001040.

8.  Kamitaki, N., Sekar, A., Handsaker, R.E., de Rivera, H., Tooley, K., Morris, D.L., Taylor, K.E., Whelan, C.W., Tombleson, P., Loohuis, L.M.O., Schizophrenia Working Group of the Psychiatric Genomics, C., Boehnke, M., Kimberly, R.P., Kaufman, K.M., Harley, J.B., Langefeld, C.D., Seidman, C.E., Pato, M.T., Pato, C.N., Ophoff, R.A., Graham, R.R., Criswell, L.A., Vyse, T.J., and McCarroll, S.A. (2020). Complement genes contribute sex-biased vulnerability in diverse disorders. Nature 582, 577-581. PMC7319891.

9.  Kari, E., Llaci, L., Go, J.L., Naymik, M., Knowles, J.A., Leal, S.M., Rangasamy, S., Huentelman, M.J., Liang, W., Friedman, R.A., and Schrauwen, I. (2020a). Genes Implicated in Rare Congenital Inner Ear and Cochleovestibular Nerve Malformations. Ear Hear 41, 983-989.

10.  Kari, E., Llaci, L., Go, J.L., Naymik, M., Knowles, J.A., Leal, S.M., Rangasamy, S., Huentelman, M.J., Liang, W., Friedman, R.A., and Schrauwen, I. (2020b). Genes Implicated in Rare Congenital Inner Ear and Cochleovestibular Nerve Malformations. Ear Hear.

11.  Kim, J.M.H., Camarena, A., Walker, C., Lin, M.Y., Wolseley, V., Souaiaia, T., Thornton, M., Grubbs, B., Chow, R.H., Evgrafov, O.V., and Knowles, J.A. (2020). Robust RNA-Seq of aRNA-amplified single cell material collected by patch clamp. Scientific reports 10, 1979. PMC7004989.

12.  Kovner, R., Souaiaia, T., Fox, A.S., French, D.A., Goss, C.E., Roseboom, P.H., Oler, J.A., Riedel, M.K., Fekete, E.M., Fudge, J.L., Knowles, J.A., and Kalin, N.H. (2020). Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early-Life Anxious Temperament. Biological psychiatry 88, 638-648. PMC7530008.

13.  Moon, S., Lee, S., Caesar, J.A., Pruchenko, S., Leask, A., Knowles, J.A., Sinon, J., and Chaqour, B. (2020). A CTGF-YAP Regulatory Pathway Is Essential for Angiogenesis and Barriergenesis in the Retina. iScience 23, 101184. PMC7270711.

14.  Samuels, J., Bienvenu, O.J., Krasnow, J., Wang, Y., Grados, M.A., Cullen, B., Goes, F.S., Maher, B., Greenberg, B.D., McLaughlin, N.C., Rasmussen, S.A., Fyer, A.J., Knowles, J.A., McCracken, J.T., Piacentini, J., Geller, D., Stewart, S.E., Murphy, D.L., Shugart, Y.Y., Riddle, M.A., and Nestadt, G. (2020). General personality dimensions, impairment and treatment response in obsessive-compulsive disorder. Personal Ment Health 14, 186-198. PMC7202992.

15.  Shen, X., Howard, D.M., Adams, M.J., Hill, W.D., Clarke, T.K., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., Deary, I.J., Whalley, H.C., and McIntosh, A.M. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nat Commun 11, 2301. PMC7210889.

16.  Whitman, M.C., Di Gioia, S.A., Chan, W.M., Gelber, A., Pratt, B.M., Bell, J.L., Collins, T.E., Knowles, J.A., Armoskus, C., Pato, M., Pato, C., Shaaban, S., Staffieri, S., MacKinnon, S., Maconachie, G.D.E., Elder, J.E., Traboulsi, E.I., Gottlob, I., Mackey, D.A., Hunter, D.G., Engle, E.C., and Strabismus Genetics Research, C. (2020). Recurrent Rare Copy Number Variants Increase Risk for Esotropia. Investigative ophthalmology & visual science 61, 22. PMC7443120.

17.  Yilmaz, Z., Halvorsen, M., Bryois, J., Yu, D., Thornton, L.M., Zerwas, S., Micali, N., Moessner, R., Burton, C.L., Zai, G., Erdman, L., Kas, M.J., Arnold, P.D., Davis, L.K., Knowles, J.A., Breen, G., Scharf, J.M., Nestadt, G., Mathews, C.A., Bulik, C.M., Mattheisen, M., Crowley, J.J., and Eating Disorders Working Group of the Psychiatric Genomics Consortium, T.S.O.-C.D.W.G.o.t.P.G.C. (2020). Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder. Molecular psychiatry 25, 2036-2046. PMC6367065.

18.  Andlauer, T.F.M., Guzman-Parra, J., Streit, F., Strohmaier, J., Gonzalez, M.J., Gil Flores, S., Cabaleiro Fabeiro, F.J., Del Rio Noriega, F., Perez, F.P., Haro Gonzalez, J., Orozco Diaz, G., de Diego-Otero, Y., Moreno-Kustner, B., Auburger, G., Degenhardt, F., Heilmann-Heimbach, S., Herms, S., Hoffmann, P., Frank, J., Foo, J.C., Treutlein, J., Witt, S.H., Cichon, S., Kogevinas, M., Bipolar Disorder Working Group of the Psychiatric Genomics, C., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., Rivas, F., Mayoral, F., Muller-Myhsok, B., Forstner, A.J., Nothen, M.M., and Rietschel, M. (2019). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular psychiatry.

19.  Barbu, M.C., Zeng, Y., Shen, X., Cox, S.R., Clarke, T.K., Gibson, J., Adams, M.J., Johnstone, M., Haley, C.S., Lawrie, S.M., Deary, I.J., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., andMe Research, T., McIntosh, A.M., and Whalley, H.C. (2019). Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biol Psychiatry Cogn Neurosci Neuroimaging 4, 91-100. PMC6374980.

20.  Bigdeli, T.B., Genovese, G., Georgakopoulos, P., Meyers, J.L., Peterson, R.E., Iyegbe, C.O., Medeiros, H., Valderrama, J., Achtyes, E.D., Kotov, R., Stahl, E.A., Abbott, C., Azevedo, M.H., Belliveau, R.A., Bevilacqua, E., Bromet, E.J., Byerley, W., Carvalho, C.B., Chapman, S.B., DeLisi, L.E., Dumont, A.L., O'Dushlaine, C., Evgrafov, O.V., Fochtmann, L.J., Gage, D., Kennedy, J.L., Kinkead, B., Macedo, A., Moran, J.L., Morley, C.P., Dewan, M.J., Nemesh, J., Perkins, D.O., Purcell, S.M., Rakofsky, J.J., Scolnick, E.M., Sklar, B.M., Sklar, P., Smoller, J.W., Sullivan, P.F., Macciardi, F., Marder, S.R., Gur, R.C., Gur, R.E., Braff, D.L., Consortium on the Genetics of Schizophrenia, I., Nicolini, H., Escamilla, M.A., Vawter, M.P., Sobell, J.L., Malaspina, D., Lehrer, D.S., Buckley, P.F., Rapaport, M.H., Knowles, J.A., Genomic Psychiatry Cohort, C., Fanous, A.H., Pato, M.T., McCarroll, S.A., and Pato, C.N. (2019). Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry. Molecular psychiatry.

21.  Charney, A.W., Stahl, E.A., Green, E.K., Chen, C.Y., Moran, J.L., Chambert, K., Belliveau, R.A., Jr., Forty, L., Gordon-Smith, K., Lee, P.H., Bromet, E.J., Buckley, P.F., Escamilla, M.A., Fanous, A.H., Fochtmann, L.J., Lehrer, D.S., Malaspina, D., Marder, S.R., Morley, C.P., Nicolini, H., Perkins, D.O., Rakofsky, J.J., Rapaport, M.H., Medeiros, H., Sobell, J.L., Backlund, L., Bergen, S.E., Jureus, A., Schalling, M., Lichtenstein, P., Knowles, J.A., Burdick, K.E., Jones, I., Jones, L.A., Hultman, C.M., Perlis, R., Purcell, S.M., McCarroll, S.A., Pato, C.N., Pato, M.T., Di Florio, A., Craddock, N., Landen, M., Smoller, J.W., Ruderfer, D.M., and Sklar, P. (2019). Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases. Biological psychiatry 86, 110-119. PMC6586545.

22.  Czamara, D., Eraslan, G., Page, C.M., Lahti, J., Lahti-Pulkkinen, M., Hamalainen, E., Kajantie, E., Laivuori, H., Villa, P.M., Reynolds, R.M., Nystad, W., Haberg, S.E., London, S.J., O'Donnell, K.J., Garg, E., Meaney, M.J., Entringer, S., Wadhwa, P.D., Buss, C., Jones, M.J., Lin, D.T.S., MacIsaac, J.L., Kobor, M.S., Koen, N., Zar, H.J., Koenen, K.C., Dalvie, S., Stein, D.J., Kondofersky, I., Muller, N.S., Theis, F.J., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., Raikkonen, K., and Binder, E.B. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nat Commun 10, 2548. PMC6559955.

23.  Doostparast Torshizi, A., Armoskus, C., Zhang, H., Forrest, M.P., Zhang, S., Souaiaia, T., Evgrafov, O.V., Knowles, J.A., Duan, J., and Wang, K. (2019). Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia. Sci Adv 5, eaau4139. PMC6739105.

24.  Drange, O.K., Smeland, O.B., Shadrin, A.A., Finseth, P.I., Witoelar, A., Frei, O., Psychiatric Genomics Consortium Bipolar Disorder Working, G., Wang, Y., Hassani, S., Djurovic, S., Dale, A.M., and Andreassen, O.A. (2019). Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Front Neurosci 13, 220. PMC6425305.

25.  Epi25 Collaborative. Electronic address, s.b.u.e.a., and Epi, C. (2019). Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals. American journal of human genetics105, 267-282. PMC6698801.

26.  Fox, A.S., Souaiaia, T., Oler, J.A., Kovner, R., Kim, J.M.H., Nguyen, J., French, D.A., Riedel, M.K., Fekete, E.M., Rabska, M.R., Olsen, M.E., Brodsky, E.K., Alexander, A.L., Block, W.F., Roseboom, P.H., Knowles, J.A., and Kalin, N.H. (2019). Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates. Biological psychiatry.

27.  Gerstenblith, T.A., Jaramillo-Huff, A., Ruutiainen, T., Nestadt, P.S., Samuels, J.F., Grados, M.A., Cullen, B.A., Riddle, M.A., Liang, K.Y., Greenberg, B.D., Rasmussen, S.A., Rauch, S.L., McCracken, J.T., Piacentini, J., Knowles, J.A., Nestadt, G., and Bienvenu, O.J. (2019). Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder. Compr Psychiatry 94, 152123.

28.  Glanville, K.P., Coleman, J.R.I., Hanscombe, K.B., Euesden, J., Choi, S.W., Purves, K.L., Breen, G., Air, T.M., Andlauer, T.F.M., Baune, B.T., Binder, E.B., Blackwood, D.H.R., Boomsma, D.I., Buttenschon, H.N., Colodro-Conde, L., Dannlowski, U., Direk, N., Dunn, E.C., Forstner, A.J., de Geus, E.J.C., Grabe, H.J., Hamilton, S.P., Jones, I., Jones, L.A., Knowles, J.A., Kutalik, Z., Levinson, D.F., Lewis, G., Lind, P.A., Lucae, S., Magnusson, P.K., McGuffin, P., McIntosh, A.M., Milaneschi, Y., Mors, O., Mostafavi, S., Muller-Myhsok, B., Pedersen, N.L., Penninx, B., Potash, J.B., Preisig, M., Ripke, S., Shi, J., Shyn, S.I., Smoller, J.W., Streit, F., Sullivan, P.F., Tiemeier, H., Uher, R., Van der Auwera, S., Weissman, M.M., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., O'Reilly, P.F., and Lewis, C.M. (2019). Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biological psychiatry.

29.  Grove, J., Ripke, S., Als, T.D., Mattheisen, M., Walters, R.K., Won, H., Pallesen, J., Agerbo, E., Andreassen, O.A., Anney, R., Awashti, S., Belliveau, R., Bettella, F., Buxbaum, J.D., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Cerrato, F., Chambert, K., Christensen, J.H., Churchhouse, C., Dellenvall, K., Demontis, D., De Rubeis, S., Devlin, B., Djurovic, S., Dumont, A.L., Goldstein, J.I., Hansen, C.S., Hauberg, M.E., Hollegaard, M.V., Hope, S., Howrigan, D.P., Huang, H., Hultman, C.M., Klei, L., Maller, J., Martin, J., Martin, A.R., Moran, J.L., Nyegaard, M., Naerland, T., Palmer, D.S., Palotie, A., Pedersen, C.B., Pedersen, M.G., dPoterba, T., Poulsen, J.B., Pourcain, B.S., Qvist, P., Rehnstrom, K., Reichenberg, A., Reichert, J., Robinson, E.B., Roeder, K., Roussos, P., Saemundsen, E., Sandin, S., Satterstrom, F.K., Davey Smith, G., Stefansson, H., Steinberg, S., Stevens, C.R., Sullivan, P.F., Turley, P., Walters, G.B., Xu, X., Autism Spectrum Disorder Working Group of the Psychiatric Genomics, C., Bupgen, Major Depressive Disorder Working Group of the Psychiatric Genomics, C., andMe Research, T., Stefansson, K., Geschwind, D.H., Nordentoft, M., Hougaard, D.M., Werge, T., Mors, O., Mortensen, P.B., Neale, B.M., Daly, M.J., and Borglum, A.D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature genetics 51, 431-444. PMC6454898.

30.  Harold, D., Connolly, S., Riley, B.P., Kendler, K.S., McCarthy, S.E., McCombie, W.R., Richards, A., Owen, M.J., O'Donovan, M.C., Walters, J., Wellcome Trust Case Control, C., Schizophrenia Working Group of the Psychiatric Genomics, C., Donohoe, G., Gill, M., Corvin, A., and Morris, D.W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 180, 223-231.

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