EDUCATION

PROFESSIONAL POSITIONS AND FACULTY APPOINTMENTS

Medical Research Council Research Assistant, MRC Radiobiology Laboratory (Dr. L.G.Lajtha), Department of Radiotherapy (Dr. F. Ellis), Churchill Hospital, Headington, Oxfordshire, England (1961-62).

National Health Service Research Officer (tenured), Paterson Laboratories, Christie Hospital & Holt Radium Inst. (Prof. L.G. Lajtha), Manchester, England (1962-68).

National Health Service Senior Research Officer (tenured), Paterson Laboratories, (as above), (1968-69).

Assistant Professor of Radiology, Radiation Biology & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, NY (1969-80).

Professor of Radiation Oncology (with tenure) & Director of the Radiation Biology Division, College of Medicine, and (concurrently 1992- ) Professor of Physiology and Biophysics, School of Graduate Studies, State University of New York, Downstate Medical Center (Health Science Center at Brooklyn), Brooklyn, NY (1980- ).


HONORS AND AWARDS

Member, Board of Directors, Sigma Xi Scientific Research Society (1999-2005)

Presidential Certificate of Gratitude for Contributions to Science, Faculty of Science Presidential Distinguished Lecturer, Hirosaki University, Japan (1979)

Honorary Member, Omicron Delta Epsilon - International Economics Honor Society (1978)

USDHEW/NCI Research Career Development Award (1972-77); over $4 million in funded grants; Biographee: a) American Men & Women of Science, b) Who's Who: 1) in the World, 2) in Frontier Science and Technology, 3) in Science and Engineering, 4) Worldwide, c) International Who's Who: 1) of Professional Educators, 2) of Contemporary Achievement, d) Men of Achievement, e) Biography International (Delhi), f) International Directory of Distinguished Leadership; International Travel Grants from: Royal Society (UK) and IARR (1966), USNAS/NRC (1970), USERDA (1975), RRS and USDOE (1979), RRS (1983, 1987, 1991, 1995, 1999), GSA (1988); Scholarships and stipends (declined) for Undergraduate and Graduate Study; Westinghouse Honorable Mention (1957); Pre-collegiate student Jackson Memorial Laboratory, Bar Harbor, ME (1956).


LECTURESHIPS AND VISITING PROFESSORSHIPS

MEMBERSHIP IN NATIONAL AND INTERNATIONAL ACADEMIC PROFESSIONAL ORGANIZATIONS

EDITORIAL ASSIGNMENTS WITH PROFESSIONAL JOURNALS

Dr. Lange has served (and serves) as a referee for the following journals:
1. Radiation Research
2. International Journal of Radiation Biology
3. Biophysical Journal
4. Radiation and Environmental Biophysics
5. International J. Radiation Oncology, Biology, Physics
6. Advances in Radiation Biology
7. Nature
8. Science
9. Journal of Theoretical Biology
10. Analytical Biochemistry
11. Arch. Biochem. Biophys.
12. Experimental Cell Research
13. Journal of Comparative Physiological Psychology
14. Journal of Embryology and Experimental Morphology
15. Environmental & Experimental Botany
16. Scanning Microscopy International
17. Cancer Clinical Trials
18. Cancer
19. Gynecologic Oncology
20. Radiotherapy and Oncology (J European Soc Therapeutic Radiol & Oncol)


PROFESSIONAL ADMINISTRATIVE AND/OR ELECTED POSITIONS

A. Intramural:

1. Acting Director, Experimental Radiology Division, Dept. of Radiology, University of Rochester School of Medicine & Dentistry (U of R) during Prof. L.H. Hempelmann's frequent research trips (3 months at a time) to Los Alamos (1970-80).

2. Member: Search Committee for DNA biochemist for Radiation Oncology Division, U of R Cancer Center, chaired by Prof. Alexander Dounce. Recruited Dr. K.T. Wheeler from Univ. Calif. San Francisco (1977).

3. Director, Radiation Biology Division, Dept. Radiation Oncology, SUNY Downstate (1980-). Developed Division from 1 to 8 Faculty.

4. Member: Centerwide Safety Committee (SUNY Downstate) (advised on radiological safety; played major editorial role in production of Chemical and Biological Safety Manual) (1981- ).

5. Member, Cancer Education Committee, SUNY Downstate Medical Center (1983-86).

6. Treasurer, Sigma Xi, SUNY Downstate Chapter (1991- ).

7. Member: PhosphorImager User Group Coordinating Committee (1994- ).

8. Member: Executive Committee, Coalition of Funded Investigators (1994-96). Coordinated concerns of research faculty to help administration improve research facilities.

9. Member: Executive Committee of the College of Medicine Faculty and Professional Staff, SUNY- Downstate Faculty Assembly (1994-97).
   1. Member: LCME Self-Study Section, Subcommittee on Faculty (1997).
   2. Member: Medical Advisory Board, College of Medicine, Martha Entenmann Tinnitus    Research Center, SUNY Downstate Medical Center (1999- ).
   3. Member: Crazy Ideas Committee for SUNY Downstate new 5-year Strategic Plan    (1999-2000). Developed plans for an NCI-designated Cancer Center & a Human    Genetics Center; these plans became the top two programs in the strategic plan.

13. Associate Director, Radiation Oncology Residency Program (2000- ); added two hospitals, expanded residency program 25%.


B. Extramural:

1. Member: Translational Research Committee (comprising former Tumor Biology, Biological Modifiers, and Pathology/Tumor Repository Utilization Committees), Radiation Therapy Oncology Group, National Project for NIH/NCI (Plan North American Clinical Trials)(1988- ).

2. Member: Scholarship Advisory Commiss’n, Bd. of Directors, Kosciuszko Foundation (1989- ).

3. Member: NIH/DRG/Special Review Section-3 (SBIR)(1993).

4. Member: Nominating Committee, Sigma Xi, NE Region (1997-1999).

5. Member: Board of Directors, Sigma Xi, NE Regional Director (1999-2002).

6. Member: Executive Director Search Committee, Sigma Xi (2001).


RESEARCH ACTIVITIES

1. Research Expertise and/or Projects in Progress:

A. Organismal Studies
1. Cellular Basis of Radiation Lethality
2. Cellular Basis of Aging
3. Loss of Differentiative Integrity
4. Control of Stem Cell Differentiation and Tissue Polarity

B. Mammalian Cell Studies
1. Kinetics of Induction and Repair of Potentially Lethal Lesions Induced by Ionizing Radiations
2. Drug Toxicological Studies - Cell Cycle Stage Specific Effects
3. Photo-reactivation Studies (UV)
4. Ultrasound effects
5. Development of Clinical Assays for Specific Tumor Radio- /Chemo-sensitivity
6. Development of Multi-modality Approaches To Tumor Cell Sterilization

C. DNA Studies
1. DNA size measurement: Development of accurate methodologies for the use and analysis of zone sedimentation (sucrose gradients) and pulsed-field gel electrophoresis
2. Hydrodynamic theory applied to DNA and Chromatin
3. DNA size, concentration, and shape measurement: viscoelastometry methods
4. Determination of size and conformation of mammalian chromatin/DNA
5. Higher-order Structure (Packaging) of Eukaryotic chromosomal DNA: Use of Biophysical and Polymer Theory methods - Tests of the Micelle model)
6. Kinetics of induction and rejoining of DNA double-strand breaks
7. Relationships between DNA lesions, their repair, and cell (reproductive) lethality (viral and cellular) - Tests of the DSB Model
8. Age and gender differences in DNA damage induction & repair.
9. Ultrasound effects

2. Research Grants/Contracts Obtained

Track record as Principal Investigator and co-Investigator on funded grants totaling > $4,000,000.


PRESENTATIONS AT MAJOR NATIONAL AND INTERNATIONAL MEETINGS
(See Publications and Abstracts) (last 15 years)

1986 Radiation Research Society 34th Annual Meeting (2 papers)
1986 Biophysical Society 30th Annual Meeting (2 papers)
1986 ICN-UCLA Symposium on DNA Replication & Recombination (1)
1986 Gordon Conference on Mammalian DNA Repair (1 paper)
1987 Radiation Research Society 35th Annual Meeting (2 papers)
1987 Conference on Prediction of Tumor Treatment Response (1 paper)
1987 8th International Congress of Radiation Research (4 papers)
1987 9th International Biophysics Congress (1 paper)
1988 Radiation Research Society 36th Annual Meeting (4 papers)
1988 ICN-UCLA Symposium on DNA Repair (1 paper)
1988 Biophysical Society 32nd Annual Meeting (1 paper)
1988 XVIth International Genetics Congress (Invited workshop chrmn)
1989 Radiation Research Society 37th Annual Meeting (3 papers)
1990 Radiation Research Society 38th Annual Meeting (4 papers)
1991 Radiation Therapy Oncology Group Workshop (Invited paper)
1991 9th International Congress of Radiation Research (3 papers)
1991 UCLA Symposium on Genetic Instability and Cancer (1 paper)
1991 McGill Univ Intnatl Symp on Predictive Assays (Invited paper)
1991 Amer. Assoc. Cancer Res. Symp on DNA Repair (1 paper)
1992 Radiation Research Society 40th Annual Meeting (4 papers)
1993 Radiation Research Society 41st Annual Meeting (3 papers)
1993 9th Biomolecular StereoDynamics Meeting (1 paper)
1993 New York Acad. Sciences DNA Structural Damage Mtg. (2 papers)
1994 Radiation Research Society 42nd Annual meeting (4 papers)
1995 Radiation Research Society 43rd Annual meeting (workshop speaker + 2 papers)
1995 10th International Congress of Radiation Research (session co-chair + 3 papers)
1997 Radiation Research Society 45th Annual meeting (3 papers)
1998 Radiation Research Society 46th Annual meeting (2 papers)
1999 11th International Congress of Radiation Research (workshop spkr + 2 papers)
1999 11th Biomolecular StereoDynamics Meeting (1 paper)
2000 Radiation Research Society 47th Annual meeting (2 papers)
2001 Radiation Research Society 48th Annual meeting (1 abstract; was unable to attend)


EDUCATION CONTRIBUTIONS

1. Graduate students:
(a) Ph.D Thesis supervision: 5 students (Liberman, Steele, Sheck, Fu, Newmeyer)

(b) Thesis Committee member: 9 students

(c) Courses taught at the University of Rochester School of Medicine & Dentistry:
RBB 527 - Cellular & Molecular Radiobiology
RBB 568 - Cellular Repair Mechanisms Seminar
RBB 530 - Cellular & Molecular Rad. Biol. Lab course
RBB 565 - Cell Cycle Kinetics Seminar
RBB 441 - Intro. to Radiation Biology & Biophysics
RBB 574 - DNA Repair Mechanisms Seminar
RBB 561 - Aging Mechanisms Seminar

2. Postgraduate students/Residents

(a) Courses taught at SUNY Downstate Medical Center (Health Sci Ctr Bklyn):
Radiation Oncology: Radiobiology for Radiotherapists
Radiation Oncology: Radiobiology tutorials
Radiation Oncology: M602 Radiation Biology (Med students)
Radiation Oncology: M603 Radiation Biol Lab (Med students)
Radiation Biology lectures (11 p.a.) in Departments of Pathology, Med./Oncology, Dermatology, Ob/Gyn, and Hematology/Oncology.
Graduate Seminars in Depts. of Biochemistry and Pathology
Graduate School Lectures: DNA Repair (in Molecular & Cellular Biology Course)

(b) Courses taught at affiliated Hospitals:
College Health Related Professions: Radiation Biology elective
Long Island College Hospital: Radiobiology for Radiologists

(c) Advising of Research & Postdoctoral Students: 1-3 annually.

3. Postdoctoral fellows (#3-6 came with own funding):

(1) (R.W. Clark) (1974-80), promoted to Ass't Prof. (1978, under Dr. Lange's supervision).

(2) (L.E. Sheck) (1977-80) on NIH postdoctoral training grant.

(3) (M. Kapiszewska) (1987) Kosciuszko Foundation Fellow (from Poland)(also, external supervisor for her Dr. Hab. (D.Sc.) Thesis for The Jagiellonian University, Poland)

(4) (K. Czieska) (1992) Kosciuszko Foundation Fellow (Jagiellonian Univ., Poland)

(5) (J. Wang) (1995/6) World Health Organization Fellow (Chengdu Cancer Ctr, PR China)

(6) (B Cedervall) (1996/7) The Swedish Foundation (Karolinska Inst., Sweden)

4. Research education:

(1) Research supervision of Radiation Oncology Residents (2-3 annually since 1981).

(2) Research supervision of Visiting Research Assistant/Associate Professors from Poland, Germany, China, the United Arab Emirates, Sweden, etc. (since 1986).

(3) Offers 10 week summer research training experiences to numerous predoctoral students, and annually to local precollegiate and undergraduate students who wish to work in Dr. Lange's laboratory. All of the premed undergraduate students who worked in his laboratory were accepted at the medical school of their choice. Two HS students won highest honors at the Long Island Science Fair and one won first place in the NYS Science Congress; both were Westinghouse Semifinalists (1991; and went on to MIT and Harvard; a third student went to Dartmouth (1994)). Of the under-represented minority students funded by his Minority High School Summer Research Apprentice grant in 1993, 2/6 won Westinghouse semifinalist honors (highest rate from any institution). The High School Science teachers continue to consult with Dr. Lange regarding planning of critical thinking experiments for their students.

5. Continuing education:

(1) Faculty, Postdocs, Graduate Students: Organizer of weekly seminar group on "DNA, Chromosomes and Cells" since 1972; also organized numerous CME credit seminars and symposia at SUNY.

(2) Sigma Xi & Cancer Center Lecture Series: organized a weekly "Brown bag" seminar with presentations by faculty on their Cancer-related research (1998-9).

INVITED LECTURES

1975

(1) Dept. of Biochemistry, University of Florida, Gainesville, Florida

(2) Dept. of Radiology, Radiation Biology & Biophysics, Colorado State University, Ft. Collins, Colorado

(3) Radiobiology Group, Los Alamos National Laboratory, Los
Alamos, N.M.

(4) The Biophysics Institute of the Polish Academy of Sciences, Warsaw, Poland

(5) The Nuclear Research Institute, Warsaw, Poland

1976

(1) Dept. of Physiology & Biophysics, University of Illinois at Champaign/Urbana, Illinois

(2) Dept. of Radiobiology, University of Wisconsin Medical School, Madison, Wisconsin

(3) Dept. of Radiology, Radiation Biology Division, School of Medicine, Case Western Reserve University, Cleveland, Ohio

(4) Dept. of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland

1977

(1) The Nuclear Research Institute, Warsaw, Poland (special joint session with the Polish Academy of Sciences)

(2) Brookhaven National Laboratory, Long Island, New York

(3) Burroughs-Wellcome Research Division, Research Triangle Park, North Carolina

(4) Invited speaker, International Symposium on DNA Damage, Academy of Sciences, German Democratic Republic

1978

(1) The Shields Warren Laboratories, Harvard Medical School, Boston, Massachusetts

(2) Dept. of Biochemistry, Eastern Virginia Medical School, Norfolk, Virginia.

(3) Dept. of Radiation Oncology, University of Tennessee, Center for the Health Sciences, Memphis, Tennessee

1979

(1) Dept. of Radiation Therapy & Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pa.

(2) University of Hirosaki, Japan; Presidential Invited Lectures as part of their 30th Anniversary Commemoration. Awarded Presidential "Certificate of Gratitude".

1980

(1) Dept. of Chemistry, University of Maryland, Baltimore County, Maryland

(2) Bureau of Rad Health, U.S.F.D.A., Rockville, Maryland

(3) Dept. of Nuclear Engineering, M.I.T., Cambridge, Massachusetts

(4) Dept. of Environmental & Occupational Health Science, School of Public Health, University of Illinois Medical Center, Chicago, Illinois

(5) Dept. of Biology, Utica College of Syracuse University, Utica, New York

(6) Dept. of Radiation Oncology, SUNY/Downstate Medical Center, Brooklyn, New York

1985

(1) Gesellschaft fur Strahlenforschung, Frankfurt, FRG

(2) Abteilung fur Strahlenbiologie, Gesellschaft fur Strahlen und Umweltforschung GmbH., Neuherberg, FRG

(3) MRC Radiobiology Unit, Harwell, Oxfordshire, UK

1987

(1) St. Andrew's College, Scotland, UK

(2) MRC Radiobiology Unit, Hammersmith Hospital Cyclotron Unit, London, UK

1988

(1) XVIth International Congress of Genetics, Toronto, Canada

(2) Dept. of Physics, Wake Forest University and Dept. of Radiology, Bowman Gray Medical School, Winston-Salem, NC.

1990

(1) Dept of Radiation Oncology, Thomas Jefferson Medical College, Philadelphia, PA.

(2) Radiation Therapy Oncology Group, Tumor Biology Committee, Philadelphia, PA.

1991

(1) McGill University International Workshop on Radioresistance of Human Tumors: Mechanisms and Prediction, Montreal, Quebec, Canada.

1993

(1) Armstrong Labs, US Air Force, San Antonio, TX.

1995

(1) 43rd Annual Meeting of the Radiation Research Society, San Jose, CA. Workshop on Topoisomerases: Mechanisms of action and application. WS-15.

(2) 10th International Congress for Radiation Research, Wurzburg, Germany, Co- chair, Workshop W-15: "Does DNA repair determine cellular recovery?".

1998

(1) Dept of Radiation Oncology, Universita Cattolica del Sacro Cuore, Istituto di Radiologia, Rome, Italy

1999

(1) 11th Congress of Radiation Research (Dublin, Eire), Workshop on "Bystander Effects".

2000

(1) Sichuan Cancer Hospital & Institute, Chengdu, Sichuan, P.R. China.

2001

(1) Biophysics Institute, Jagiellonian University, Krakow, Poland

(2) Academia Ekonomiczna, University of Wroclaw, Wroclaw, Poland


1973-1980 Dr. Lange served as an AIBS/ERDA program lecturer (Visiting Radiation Biologist) for the Northeast and West Sections of the United States. These lectures (1-8 annually, primarily to Undergraduates) are not listed here.


CONSULTATIONS TO UNIVERSITITES, HEALTH AND SCIENCE AGENCIES, FOUNDATIONS, LAW FIRMS, AND BIOTECH COMPANIES

1 Universities:

(a) Consulted for Faculty Peer Review Research Evaluation by SUNY at Buffalo (1972).

(b) Appointed an External Member of the Board of Examiners (Physiology) of the University of Calcutta, India (1976).

(c) Appointed as a consultant on upgrading of the Radiation Oncology Division of the Center for the Health Sciences of the University of Tennessee at Memphis (1978).

(d) Appointed an External Examiner to the Microbiology Dept. of New York Medical College at Valhalla, NY (1983).

(e) Consulted for Faculty evaluation for tenure by Johns Hopkins University School of Medicine (1987).

2 Health and Science Agencies:

(a) Consulted for Research Contract Proposal Evaluation by ERDA (1972).

(b) Consulted for Research Contract Proposal Evaluation by DOE (1977,1979).

(c) Consulted for Research Contract Proposal Evaluation by NSF (1978, 1987).

(d) Consulted by USFDA/BRH for Evaluation of their Research Program (1980).

(f) Consulted by NCI Radiation Study Section for Research Grant Proposal Evaluation (1981).

(g) Consulted by Amer. Inst. of Ultrasound in Med. Bioeffects Committee for Research Program Evaluation (1983, 1987).

(h) Consulted by the Veterans Administration for Research Grant Proposal Evaluation (1988).

(i) Appointed Member: Special Study Section 3 (NIH) (1993).

(j) Consulted by USFDA/BRH for evaluation of a senior staff member for promotion to the Senior Biomedical Research Service within FDA (1995).

3 Foundations:

(a) Fellowship evaluation Commission for Kosciuszko Foundation (1989 - present)

4 Biotech Companies:

(a) Consultant on NIH/SBIR grant to ImmunoSciences, New Hyde Park, NY (1994).

5 Law Firms:
(a) Scientific Consultant to Alston & Bird, LLC (2000- ).


INVENTION DISCLOSURES AND PATENTS (SELF AND DIVISION)

1. Invention No. S-280, "Control of Diffusion-Controlled Reactions by Solvent Viscosity and Temperature Control". C.S. Lange and J.Y. Ostashevsky.

2. Invention No. R-283, "The Use of Viscoelastometry to Determine Secondary and Tertiary Molecular Structures". C.S. Lange and J.Y. Ostashevsky.

3. Invention No. R-312, "A Clinical Assay for Radiation Therapy Treatment Planning". C.S. Lange and J.Y. Ostashevsky.

4. U.S. Patent # 5,023,172. Predictive Assay for Tumor Control. Bozidar Djordjevic. The Research Foundation of SUNY. June 11, 1991.

5. U.S. Patent # 6,020,146. Carcinogenicity Testing System. Bozidar Djordjevic. The Research Foundation of SUNY. Feb. 1, 2000.


COMMUNITY SERVICE

Dr. Lange has served in the following elective positions for a major national political party:

1. Committeeperson, Town of Brighton, NY (1972-74).

2. Committeeperson, City of Rochester, NY (1974-80).

3. Committeeperson, 64th ED, 16th AD, Village of Munsey Park (1986-92), 60th ED, 16th AD, Village of Flower Hill, Manhasset, NY (1992- ).

4. Zone Chairman, Manhasset Zone, 16th AD (1987- ).

5. Executive Committee, Town of North Hempstead, Nassau County, NY (1988- ).

6. Executive Committee, Nassau County, NY (1988- ).