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Research
Determinants of HIV Testing and Perinatal ZDV Use: This study is assessing prenatal HIV testing and perinatal ZDV use in six hospitals in Brooklyn. The study is examining: (1) provider and client factors as interrelated determinants of HIV test taking and perinatal ZDV use; (2) the adverse social and psychological consequences of women found to be HIV infected; and (3) how to design a program which can reliably monitor the success of protocols implemented to enhance HIV testing rates. The study is funded by the CDC.
HIV Clinical Trials: The STAR Health Center is currently conducting a number of clinical trials. These include a study of the effect of a weekly dosing regime of procrit (epoetin alfa) on the quality of life in the treatment of anemia in HIV-infected patients on antiretroviral therapy, an open-label pilot study to evaluate the safety and efficacy of Indinavir twice a day in combination with Ritonavir/d4T/3TC, and an open-label study to determine the efficacy and safety of Serostim in HIV patients with unintentional weight loss or body cell mass depletion on combination antiretroviral therapy with or without protease inhibitors. The following trials were completed in 1999: a Phase IV, non-comparative study to evaluate Fortavase soft gel capsule regimen with two NRTIs in HIV-1 infected women and men, identification of HIV-1 urine antibody positive, HIV-1 seronegative individuals, an open label, multi-center study to assess the safety and antiviral activity of a twice daily dosing regimen of Viracept combined with 2 RTIs in HIV-infected treatment-naive patients, a randomized, controlled trial of SCH 56592 oral suspension vs. Fluconazole tablets in the treatment of oropharyngeal candidiasis in HIV-infected patients. These trials are funded by Ortho Biotech, Merck and Company, Serano, Roche, Calypte, Agouron and Schering Plough.
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