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SUNY Downstate Medical Center

Department of Physiology and Pharmacology

Research

The Department of Physiology and Pharmacology currently has a well-funded and very active body of researchers. At present our principal emphasis is on brain function and neurological disorders, but we also have faculty actively investigating antibody diversification mechanisms and regulatory RNAs. Members of the faculty are gaining significant international recognition for their work. These cutting-edge research groups include the following areas of investigation:

  • the molecular mechanisms underlying learning and memory
  • translational control in neurons
  • the pharmacology and physiology of epilepsy
  • contribution of capillary vasodynamics to ictal neurodegeneration in epilepsy
  • traumatic brain injury
  • drug therapies used during adolescence used to normalize synapse number

Find the pages describing individual faculty member’s research.

 

cell photo

A hippocampal neuron in primary culture. The cell was labeled with an antibody against phosphorylated eukaryotic initiation factor (eIF) 4B (green) and an antibody against the presynaptic marker synaptophysin (red). Following receptor activation, eIF4B is rapidly dephosphorylated in a mechanism that switches BC RNA translational control from repressive to permissive, thus enabling initiation of local protein synthesis. From Eom et al., Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. J. Cell Biol. 207:237-252 (2014). Illustration courtesy of Drs. Ilham Muslimov and Taesun Eom.