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Research Activities and Grants

Photo of WR Treem

WR Treem

Pediatrics

Professor

Mackey J, Treem WR, Worley G, et al. Frequency of celiac disease in individuals with Down syndrome in the United States. Clin Pediatr 2001;40:249-252.

Orenstein SR, Blumer JL, Faessel HM, Pappa KA, McGuire JA, Furg K, Li B, Lavine JE, Treem WR, Ciociola AA. Ranitidine, 75 mg, over-the-counter dose: pharmacokinetic and pharmacodynamic effects in children with symptoms of gastro-esophageal reflux. Alimentary Pharmacology & Therapeutics, 16(5):899-907, May 2002.

Treem WR. Mitochondrial fatty acid oxidation and acute fatty liver of pregnancy. Seminars in Gastrointestinal Dis, 2002;13:55-66.

Kader HA, Berman WF, Al-Seraihy AS, Ware RE, Ulshen MH, Treem WR. Prevalence of factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase G677T thrombophilic mutations in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 2002;35:629-635.

Ware RE, Zimmerman SA, Sylvestre PB, Davis JS, Treem WR, Schutz WH. Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy. J Pediatr, 2004; 145:346-352.

Treem WR. Emerging concepts in celiac disease. Current Opinion in Pediatrics, 2004;16:552-559.

Hyams J, Markowitz J, Otley A, Rosh J, Mack D, Bousvaros A, Kugathasan S, Pfefferkorn M, Tolia V, Evans J, Treem WR, Wyllie R, rothbaum R, del Rosario J, Katz A, Mezoff A, Oliva-Hemker M, Lerer T, Griffiths A, for the Pediatric Inflammatory Bowel Disease Collaborative Research Group. Evaluation of the pediatric Crohn's disease activity index: a prospective multi-center experience. J Pediatr Gastroenterol Nutr, 2005;41:416-421.

Wang J, Cortina G, Wu V, Tran R, Cho JH, Tsai MJ, Bailey T, Jamrich M, Ament M, Treem WR, Hill I, Vargas J, Gershman G, Farmer D, Reyen L, Martin M. Homozygote mutations of Neurogenin-3 in children with congenital generalized malabsorptive diarrhea and dysgenesis of enteroendocrine cells. N Engl J Med 2006; 355: 270-280.

Cortina G, Burge CN, Farmer D, Bhuta S, Treem WR, Hill I, Martin MG. Enteroendocrine cell dysgenesis and malabsorption, a histopathological and immunohistochemical characterization. Human Pathology 2007;38:570-580.

Matern D, Hart P, Murtha AP, Vockley J, Gregersen N, Millington DS, Treem WR. Acute fatty liver of pregnancy associated with short-chain acyl-coenzyme A dehydrogenase deficiency. J Pediatrics, 2001;138:585-588.

Hochman JA, Treem WR, Dougherty F, Bentley RC. Mucolipidosis II (I-Cell disease) presenting as neonatal cholestasis. J Inher Metab Dis, 2001;24:603-604.

Rosoff PM, Tuttle-Newhall E, Treem WR Successful treatment of immune thrombocytopenic purpura with anti-D antibody following a cadaveric liver transplant for hepatoblastoma. Med Ped Oncol, 2003;40:402-404.

Lazarre F, Nguyen K, Kaistha A, Treem WR. A previously undescribed CFTR mutation in a Hispanic infant presenting with meconium ileus and perforation. Submitted, J Cystic Fibrosis, 2007.

Chogle A, Nguyen K, Lazare F, Guzman M, Anderson V, Treem WR. Gastric Burkitt's Lymphoma: A rare cause of upper gastrointestinal bleeding in a child with HIV/AIDS. Submitted, J Pediatr Gastroenterol Nutr, 2007.

Treem WR. Pediatric Biliary Diseases. Baillie J, Clavien P (eds.) Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment. Blackwell Science, 2001;309-334.

Treem WR. Assessing Crying Complaints: Interaction with Gastroesophageal Reflux and Cows Milk Protein Intolerance. In New Evidence on Unexplained Early Infant Crying: Its Origins, Nature, and Management. Johnson and Johnson Pediatric Round Table, 2001;165-176.

Treem WR. Special Considerations for Liver Transplantation in Children. In Clavien PA, Killenberg (eds). Medical Care of the Liver Transplant Patient. Second Edition. Blackwell Scientific Publishers, London, 2001;393-432.

Sokol R, Treem WR. Mitochondrial Hepatopathies. In Suchy F, Sokol R, Balistreri W (eds). Liver Disease in Children. Lippincott, Williams, Wilkins (2nd edition) Philadelphia, 2001; 787-801.

Sokol RJ, Treem WR, Mitochondrial hepatopathies in infants and children: primary and secondary disorders (Hepatopatias Mitocondriais em Lactentes e em Criancas: Disturbios Primarios e Secundarios) In: da Costa Gayotto LC, Alves VAF (eds.). Diseases of the Liver and Biliary Tract, (Doencas do Figado e Vias Biliares), 2001; 335-347.

Treem WR. Inborn Defects in Mitochondrial Fatty Acid Oxidation. In Suchy F, Sokal R, Balistreri W (eds). Liver Disease in Children. Lippincott, Williams, Wilkins (2nd edition) Philadelphia, 2001; 735-785.

Kader HA, Berman WF, Al-Seraihy AS, Ware RE, Ulshen MH, Treem WR. Prevalence of Factor V (Leiden), Prothrombin G 20210A, and methylenetetrahydrofolate redctase C677T thrombophilic mutations in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 2001;33:371.

Ware RE, Sylvestre PB, MacKeigan SF, Treem WR, Davis JS, Zimmerman SA, Schulz WH. Complete resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and repeated phlebotomy. Presented at the American Society of Hematology, Orlando FL, December 2001;Blood 98:492a.

Treem WR. Gastrointestinal Bleeding. In Lifschitz, CH (ed). Pediatric Gastroenterology and Nutrition in Clinical Practice. Marcel Dekker, Inc. New York, NY, 2002; 615-649.

Treem WR. Fulminant Hepatic Failure in Children. J Pediatr Gastroenterol Nutr, 2002;35 (suppl 1):533-538.

Oden J, Treem WR. Inborn Errors in Fasting Adaptation. Walker A, Watkins JB (eds). In Nutrition Pediatrics: Basic Science and Clinical Application (3rd edition) Decker, Inc., 2003, 591-608.

Treem WR, Agrawal N, Ubinger F, Ulshen M, Berman W. Use of video capsule endoscopy (CE) to diagnose occult small bowel Crohn's disease in children with persistent unexplained gastrointestinal blood loss. J Pediatr Gastroenterol Nutr, 2003;37:376

Markowitz J, Rosh J, Hyams J, Bousvaros A, Del Rosario JF, Grand R, Griffiths A, Katz A, Kugasathan S, Mack D, Mezoff A, Oliva-Hemker M, Otley A, Pfefferkorn M, Rothbaum R, Tolia V, Treem WR, Wyllie R, Chen D. Does age affect response to initial therapy in children with inflammatory bowel disease (IBD)? J Pediatr Gastroenterol Nutr, 2003;37:341

Hyams J, Markowitz J, Kugasathan S, Pfefferkorn M, Evans J, Rosh J, Mezoff A, Bousvaros A, Del Rosario J, Griffiths A, Katz A, Mack D, Oliva-Hemke M, Otley A, Rothbaum R, Tolia V, Treem WR, Wyllie R, Grand R, Greenberg J. Does early use of infliximab in children with Crohn's disease improve clinical outcome? J Pediatr Gastroenterol Nutr, 2003;37:339

Rosh J, Markowitz J, Hyams J, Bousvaros A, Del Rosario J, Evans J, Grand R, Griffiths A, Katz A, Kugasathan S, Mack D, Mezoff A, Oliva-Hemke M, Otley A, Pfefferkorn M, Rothbaum R, Tolia V, Treem WR, Wyllie R, Chen D, Greenberg J. Demographic and age-related differences in the presentation of pediatric inflammatory bowel diseases. J Pediatr Gastroenterol Nutr, 2003;37:376

Hyams J, Griffiths A, Markowitz J, Otley A, Mack D, Kugasathan S, Rosh J, Bousvaros A, Evans J, Rothbaum R, Wyllie R, Treem WR, Katz A. Re-evaluation of the pediatric Crohn's activity index: usefulness in the practice setting. J Pediatr Gastroenterol Nutr, 2004;39:suppl 1;5328

Mack D, Hyams J, Markowitz J, Griffiths A, Bousvaros A, Del Rosario J, Evans J, Grand R, Katz A, Kugasathan S, Mezoff A, Tolia V, Treem WR, Wyllie R, Lerer T. Lab parameters in children with inflammatory bowel disease (IBD) at diagnosis. J Pediatr Gastroenterol Nutr, 2004; 39:suppl 1;S310

Pfefferkorn M, Hyams J, Markowitz J, Griffiths A, Daggy J, Bousvaros A, Evans J, Grand R, Katz A, Mack D, Otley A, Rosh J, Tolia V, Treem WR, Wyllie R. Characterization of height and weight patterns in newly diagnosed children with IBD. J Pediatr Gastroenterol Nutr, 2004; 39:suppl 1;S318

Markowitz J, Hyams J, Evans J, Mack D, Oliva-Hemker M, Otley A, Pfefferkorn M, Rosh J, Tolia V, Treem WR, Smith K. NOD2 polymorphisms and their relationship to serologic markers of disease in children with IBD. Gastroenterology, 2004;126:suppl 2;A-354

Markowitz J, Rosh J, Hyams J, Bousvaros A, Del Rosario J, Evans J, Grand R, Griffiths A, Katz A, Kugasathan S, Mack D, Mezoff A, Tolia V, Treem WR, Wyllie R. Steroid therapy in the age of infliximab: intermediate and 1 year outcome in newly diagnosed children with Crohn's disease. Gastroenterology, 2004;126:suppl 2;A-627

Treem WR. Disorders of Fatty Acid Oxidation. In Wyllie R, Hyams J (eds.). Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis and Management. WB Saunders (Elsevier), Phila, PA. (3rd Edition) 2006; 883-898.

Alfie M, Treem WR. Nonalcoholic Fatty Liver Disease. Pediatric Annals, 2006; 35: 290-299.

Wang J, Cortina G, Wu V, Tran R, Tsai MJ, Cho JH, Ament, M, Treem WR, Hill I, Vargas J, Farmer D, Reyen L, Martin M. Homozygote mutations of neurogenin-3 in congenital generalized malabosrptive diarrhea and dysgenesis of enteroendocrine cells. Gastroenterology, 2006: 130; suppl 2; A-12

Treem WR. Liver transplantation for non-hepatotoxic inborn errors of metabolism. Current Gastroenterology Reports, 2006; 8: 215-223.

Treem WR. Is PEG-B the procedure of choice for PEG tube placement in children? Nature Clin Pract Gastroenterol Hepatol, 2007;4:192-193.

Treem WR. Beyond five years: Long-term follow-up in pediatric liver transplantation. Current Gastroenterology Reports 2007; 9: 230-236.