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Research Activities and Grants

Photo of M.R. Hammerschlag

M.R. Hammerschlag

Pediatrics

Professor

Principal Investigator, Hammerschlag MR, Pfizer, In vitro Activity of New Pfizer Compounds Against Chlamydia pneumoniae. 7/07-6/08.

Principal Investigator, Kumar Swati, mentor, Hammerschlag, MR Medlmunne Pediatric ID Fellowship Grant, Effects of Smoking on the Burden of Chlamydia pneumoniae Infection in the Lung and its Systemic Dissemination in Mice. 7/05-6/08

Principal Investigator, Hammerschlag MR, Focus Diagnostics, Inc. Retrospective analysis of previously cultured clinical specimens for Chlamydia pneumoniae by Focus Nucleic Acid Amplification Test, 7/07-12/07.

Boman J, Roblin PM, Sundström P, Sandström M, Hammerschlag MR. Failure to detect Chlamydia pneumoniae in the central nervous system of patients with multiple sclerosis. Neurology 54:265, 2000.

Hammerschlag MR. Chlamydia pneumoniae and atherosclerosis: what we know and what we don't know. Pediatr Infect Dis J 19:75-76, 2000.

Hammerschlag MR. Activity of gemifloxacin and other new quinolones against Chlamydia pneumoniae: a review. J Antimicrob Chemother 45: Suppl S1:35-39, 2000.

Hammerschlag MR. The role of Chlamydia in upper respiratory tract infections. Curr Infect Dis Rep 2:115-120, 2000.

Suss AL, Homel P, Hammerschlag M, Bromberg K. Risk factors for pelvic inflammatory disease in inner-city adolescents. Sex Transm Dis 27:289-91, 2000.

Strigl S, Roblin PM, Reznik T, Hammerschlag MR. In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae. Antimicrob Agents Chemother 44:1112-1113, 2000.

Strigl S, Kutlin A, Roblin PM, Shulman ST, Hammerschlag MR. Is there an association between Kawasaki Disease and Chlamydia pneumoniae? J Infect Dis 181:2103-5, 2000.

Hammerschlag MR, Roblin PM. Microbiologic efficacy of levofloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Antimicrob Agents Chemother 44:1409, 2000.

Hammerschlag MR, Roblin PM. Microbiologic efficacy of moxifloxacin for the treatment of community-acquired pneumonia due to Chlamydia pneumoniae. Int J Antimicrob Agents 15:149-152, 2000.

Roblin PM, Hammerschlag MR. In vitro activity of GAR-936 against Chlamydia pneumoniae and Chlamydia trachomatis. Int J Antimicrob Agents 16:61-63, 2000.

Ke Z, Lu F, Roblin P, Boman J, Hammerschlag MR, Kalman B. Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis? J Clin Microbiol 38:4274-6, 2000.

Hammerschlag MR. Chlamydia pneumoniae and the lung. Eur Resp J 16:1001-7, 2000.

Hammerschlag MR, Boman J, Rowley AH. Failure to demonstrate Chlamydia pneumoniae in cardiovascular tissue from children with Kawasaki Disease. Pediatr Infect Dis J 20: 76-77, 2001.

Dowell SF, Peeling RW, Boman J, Carlone GM, Fields BS, Guarner J, Hammerschlag MR, Jackson LA, Kuo CC, Maass M, Messmer TO, Talkington DF, Tondella ML, Zaki SR. Standardizing Chlamydia pneumoniae assays: Recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada). Clin Infect Dis 33:492-503, 2001.

Hammerschlag MR. Mycoplasma pneumoniae infections. Curr Op Infect Dis, 14:181-6, 2001.

Hammerschlag MR. Use of nucleic acid amplification tests in investigating child sexual abuse. Sex Transm Infect, 77:153-4, 2001.

Hammerschlag MR. Current status of laboratory diagnosis of Chlamydia pneumoniae and Chlamydia psittaci. Clin Microbiol Newsl 23:107-111, 2001.

Hammerschlag MR. Asymptomatic respiratory infection with Chlamydia pneumoniae: What does it mean? Chest 119:1303-5, 2001.

Reiss AB, Awadallah NW, Roblin PM, Chan ESL, Montesinos MC, Khoa ND, Cronstein BN, Hammerschlag MR. Immune modulation of cholesterol homeostasis. Recent Res Devel Protein Eng 1:21-38, 2001

Kutlin A, Flegg C, Stenzel D, Reznik T, Roblin PM, Mathews S, Timms P, Hammerschlag MR. Ultrastructural study of Chlamydia pneumoniae in a continuous infection model. J Clin Microbiol 39:3721-3, 2001.

Hammerschlag MR, Roblin PM, Bébéar CM. Activity of telithromycin, a new ketolide antimicrobial, against atypical and intracellular respiratory tract pathogens. J Antimicrob Chemother, 48:Topic T1, 25-31, 2001.

Boman J, Hammerschlag MR. Chlamydia pneumoniae and atherosclerosis - a critical assessment of diagnostic methods and the relevance to treatment studies. Clin Microbiol Rev 15:1-20, 2002

Kutlin A, Roblin PM, Hammerschlag MR. Effect of prolonged treatment with azithromycin, clarithromycin and levofloxacin on Chlamydia pneumoniae in a continuous infection model. Antimicrob Agents Chemother 46:409-412, 2002.

Malay S, Roblin PM, Reznik T, Kutlin A, Hammerschlag MR. In vitro activity of BMS-28476 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae. Atimicrob Agents Chemother 46:517-518, 2002.

Kutlin A, Roblin PM, Hammerschlag MR. Effect of gemifloxacin on viability of Chlamydia pneumoniae (Chlamydophila pneumoniae) in an in vitro continuous infection model. J Antimicrob Chemother 49:763-767, 2002.

Chernesky M, Smieja M, Schachter J, Summersgill J, Schindler L, Solomon N, Campbell K, Campbell LA, Cappuccio A, Gaydos C, Chong S, Moncada J, Phillips J, Jang D, Wood BJ, Petrich A, Hammerschlag MR,Cerney M, Mahony J. Comparison of an industry derived LCx® Chlamydia pneumoniae PCR research kit to in-house assays performed in five laboratories. J Clin Microbiol 40: 2357-2362, 2002.

Hammerschlag MR. Chlamydia pneumoniae and the heart: Impact of diagnostic methods. Curr Clin Topics Infect Dis 22:24-41, 2002

Hammerschlag MR. Intracellular life of Chlamydiae. Sem Pediatr Infect Dis 4:239-248, 2002.

Hammerschlag MR. Community-acquired MRSA infections: A new twist for an old bug. Infect Med 20:8-9, 2003.

Hammerschlag MR. Implications of inappropriate STD testing go beyond pure diagnostics. ASM News 69:74-79, 2003.

Roblin PM, Reznik T, Kutlin A, Hammerschlag MR. In vitro activity of rifamycin derivatives ABI-1648 (Rifalazil, KRM-1648), ABI-1657 and ABI-1131 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae. Antimicrob Agents Chemother 47:1135-1136, 2003.

Hogan R, Mathews S, Kutlin A, Hammerschlag MR Timms P. Differential expression of genes encoding membrane proteins between acute and continuous Chlamydia pneumoniae infections. Microb Pathogen 34:11-16, 2003.

Roblin PM, Reznik T, Hammerschlag MR. In vitro activity of a novel new antibiotic, NVP-PDF386, against Chlamydia pneumoniae. Antimicrob Agents Chemother 47:1447-1448, 2003.

Hammerschlag MR, Reznik T, Roblin PM, Summersgill J, Bukofzer S. Microbiologic efficacy of ABT-773 (cethromycin) for treatment of community acquired pneumonia due to Chlamydia pneumoniae. J Antimicrob Chemother 51:1025-1028, 2003.

Hammerschlag MR. Pneumonia due to Chlamydia pneumoniae in children: Epidemiology, diagnosis and treatment. Pediatr Pulmonol 36:384-390, 2003.

Cultrara A, Goldstein N, Ovchinsky A, Reznik T, Roblin PM, Hammerschlag MR. The role of Chlamydia pneumoniae in children with chronic sinusitis. Arch Otolaryngol 129:1094-1097, 2003.

Hammerschlag MR. Appropriate use of nonculture tests for the detection of sexually transmitted diseases in children and adolescents. Sem Pediatr Infect Dis 14:54-59, 2003.

Roblin PM, Reznik T, Hammerschlag MR In vitro activity of garenoxacin against recent clinical isolates of Chlamydia pneumoniae. Int J Antimicrob Agents 21:578-580, 2003.

Kohlhoff SA, Hammerschlag MR. Raccoon roundworm (Baylisascaris procyonis). Infect Med 20:218-223, 2003.

Hammerschlag MR. West Nile Virus: from epidemic to endemic. Infect Med 20:374-5, 2003.

Hammerschlag MR. Advances in the management of Chlamydia pneumoniae infections. Expert Rev Anti-Infect Ther 1:493-504, 2003.

Hammerschlag MR. Infections due to Chlamydia trachomatis and Chlamydia pneumoniae in children and adolescents. Pediatr Rev 25:43-50, 2004.

Ramilo PB, Augenbraun M, Hammerschlag MR. Recent outbreaks on cruise ships. Infect Med, 21:14-15, 2004.

Hammerschlag MR. Clinical advances in the treatment of Chlamydia pneumoniae infections. Mod Aspects Immunobiol, in press, 2004.

Goyal M, Miller ST, Hammerschlag MR, Gelling M, Gaydos CA, Hardick J, Wood BJ, Reznik T, Rao SP. Is Chlamydia pneumoniae infection associated with stroke in children with sickle cell disease? Pediatrics,113:e318-e321, 2004. URL:http://www.pediatrics.org/cgi/content/full/4/e318

Kohlhoff SA, Roblin PM, Reznik T, Hawser S, Islam K, Hammerschlag MR. In vitro activity of a novel diaminopyrimidine compound, iclaprim, against Chlamydia trachomatis and C. pneumoniae. Antimicob Agents Chemother, 48:1885-6, 2004.

Kumar S, Hammerschlag MR. The accidental tourist: Globalization and food-borne disease outbreaks. Infect Med 21:149-51, 2004.

Hammerschlag MR, Roblin PM. The in vitro activity of a new fluroquinolone, ABT-492, against recent clinical isolates of Chlamydia pneumoniae. J Antimicrob Chemother 54:281-2, 2004.

Riska PF, Kutlin A, Ajiboye P, Cua A, Roblin PM, Hammerschlag MR. Genetic and culture-based approaches for detecting microcline resistance in Chlamydia pneumoniae. Antimicrob Agents Chemother 48:3586-3690, 2004.

Alam M, Hammerschlag MR. SARS and emerging zoonoses. Infect Med 21:327-328,2004.

Kutlin A, Kohlhoff S, Roblin P, Hammerschlag MR, Riska P. Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis. Antimicrob Agents Chemother 49:903-907, 2005.

Pelton SI, Hammerschlag MR, Overcoming current obstacles in the management of bacterial community acquired pneumonia in ambulatory children. Clin Pediatr 44:1-17, 2005.

Hashimi N, Hammerschlag MR. Human metapneumovirus. Infect Med 22: 21-22, 2005.

Senn L, Hammerschlag MR, Greub G. Therapeutic approaches to Chlamydia infections. Expert Opinion Pharmacother 6:1-10, 2005.

Kumar S, Kohlhoff S, Gelling M, Roblin PM, Kutlin A, Kahane S, Friedman MG, Hammerschlag MR. Infection with Simkania negevensis in Brooklyn, New York. Pediatr Infect Dis J 24:989-992, 2005.

Apfalter P, Reischl U, Hammerschlag MR. In-house nucleic acid amplification assays in research: How much quality control is need before one can rely upon the results? J Clin Microbiol 43:5385-5841, 2005

Sleiman J. Hammerschlag, MR. ESBL-producing Gram-negative bacteria: A new threat to the community? Infect Med 23:0177-178, 2006.

Hammerschlag MR, Gaydos GA. Chlamydia pneumoniae and multiple sclerosis: fact or fiction. Lancet Neurol 5:892-893, 2006.

Kumar S, Kutlin A, Roblin P, Kohlhoff S, Bodetti T, Timms P, Hammerschlag MR. Isolation and antimicrobial susceptibilities of chlamydial isolates from western barred bandicoots. J Clin Microbiol 45:392-394, 2007.

Kumar S, Hammerschlag MR. Acute respiratory infection due to Chlamydia pneumoniae: Current status of diagnostic methods. Clin Infect Dis 44:568-576, 2007.

Sleiman JN, D'Angelo A, Hammerschlag MR. Spontaneous Escherichia coli cellulitis in a child with nephrotic syndrome. Pediatr Infect Dis J 26:266-267, 2007.

Kumar S, Kohlhoff S, Sharma R, Valencia G, Hammerschlag MR. Treatment of vancomycin resistant Enterococcus faecium ventriculitis in a neonate. Int J Antimicrob Agents 29:740-741, 2007.

Hammerschlag MR. Chlamydia and Chlamydiales: beyond Chlamydia trachomatis. Pediatr Infect Dis J, 26:639-639, 2007.

D'Angelo A, Sleiman J, Mongia A. Schoeneman M, Hammerschlag M. Peritonitis caused by Neisseria sicca in a child on chronic peritoneal dialysis. Dialysis Transplant, in press, 2007.

Kohlhoff SA, Kutlin A, Riska P, Roblin PM, Roman C, Hammerschlag MR. In vitro models of acute and long term continuous infection of human respiratory epithelial cells with Chlamydophila pneumoniae have opposing effects on host cell apoptosis. Microb Pathogen, in press, 2007.

Rours GIJG, Hammerschlag MR, De Faber JTHN, de Groot R, Verkooyen RP. Chlamydia trachomatis as a cause of neonatal conjunctivitis Dutch infants. Pediatrics, in press, 2007.

Bowser CS, Kumar S, Salciccioli, L, Kutlin A, Lazar J, Rahim I, Suss A, Kohlhoff, S, Hammerschlag MR, Moallem J. Absence of Chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosus. Pediatr Cardiol, in press, 2007

CHAPTERS

Hammerschlag MR. Conjunctivitis in a 10-day old girl. In: Burg FD, Vaughan VC, Nelson KC (eds). Pediatrics: A Problem-Based Review. W.B. Saunders, Philadelphia, pp.91-93, 2000.

Hammerschlag MR. Headache, nonproductive cough and fever in a 15 year-old boy. In: Burg FD, Vaughan VC, Nelson KC (eds) Pediatrics: A Problem-Based Review. W.B. Saunders, Philadelphia, pp.553-5, 2000.

Hammerschlag MR. Chlamydia pneumoniae and asthma and atherosclerosis: Role of macrolides. In: Schönfeld W, Kirst H (eds). Milestones in Drug Therapy: Macrolide Antibiotics. Birkhauser Publishers Ltd, Basel, Switzerland, pp. 215-228, 2002.

Hammerschlag MR. Syphilis. In: Burg FD, Inglefinger JR, Polin RA, Gershon AA (eds): Current Pediatric Therapy, 17th Edition. W.B. Saunders, Philadelphia, pp.102-104, 2002.

Hammerschlag MR. Antibiotic susceptibility and treatment of Chlamydia pneumoniae infections. In: Yamamoto T, Freidman H, Bendinelli M (eds): Chlamydia pneumoniae Infection and Diseases. Kluwer Academic/Plenum Publishers, New York, in press, 2003.

Hammerschlag MR. Chlamydia trachomatis. In: Hutto C (ed): Congenital and Perinatal Infections. A Concise Guide to Diagnosis. Humana Press, Totowa, NJ, pp. 261-269, 2005.

Hammerschlag MR. Chlamydia Infections. In: Burg FD, Inglefinger JR, Polin RA, Gershon AA (eds): Current Pediatric Therapy, 18th ed. W.B. Saunders, Philadelphia, pp. 839-841, 2006.

Kohlhoff S, Hammerschlag MR. Gonococcal and chlamydial infections in infants and children. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Cory L, Cohen M, Watts H (eds): Sexually Transmitted Diseases, 4th Ed, in press, 2007.

Hammerschlag MR, Kumar S. Chlamydia infections. In: Taussig LM, Landau LI (eds): Pediatric Respiratory Medicine, 2nd Ed, in press, 2007.

Hammerschlag MR. Chlamydia pneumoniae. In: Schlossberg D (ed): Clinical Infectious Diseases, 3rd Ed, in press, 2007.

Sleiman J, Hammerschlag MR. Conjunctivitis. In: Shah S (ed): Pediatric Practice: Infectious Diseases, in press, 2007.

Hammerschlag MR, Sleiman J. Neonatal conjunctivitis. In: Shah S (ed): Pediatric Practice: Infectious Diseases, in press, 2007.