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Juan Marcos Alarcon, PhD

Assistant Professor

Department of Pathology, Division of Neuroscience

Office location: 4-113

Lab Tel: (718) 221- 5325

Office Tel:(718)613-8348

Fax: (718) 270-3313

e-mail: juanmarcos.alarcon@downstate.edu

 

 

 

 

 

Research Interest Summary
Understanding how the brain changes with experience is a fundamental question in neuroscience. Our research projects attempt to address this question by characterizing how neuronal and synaptic circuit function changes by experience-driven neural activity.

Learn more about our laboratory at: www.alarconlab.com

 

Lab projects
Synaptic Plasticity Interactions within and between CA1 Dendritic Compartments
Functional Significance of Synaptic Plasticity Interactions
Synaptic Plasticity Correlates of the Cognitive Map
Role of PARP-1 in Learning and Memory




Selected Publications

Gaël Malleret, Juan M. Alarcon, Guillaume Martel, Shuichi Takizawa, Svetlana Vronskaya, Deqi Yin, Irene Z. Chen, Eric R. Kandel and Gleb P. Shumyatsky. (2010) Bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory. J Neurosci. 30(10):3813-25.

Barco A., Lopez de Armentia M, and Alarcon JM. (2008) Synapse-specific stabilization of plasticity processes: The synaptic tagging and capture hypothesis revisited ten years later. Neuroscience & Biobehavioral Reviews. 32(4):831-851.

Nicholls, R.E., Alarcon, J.M., Malleret, G., Vronskaya, S., Grody, M.B. and Kandel, E.R. (2008) Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron. 58(1):104-17.

Alarcon JM, Barco A and Kandel E.R. (2006) Capture of L-LTP within and across the apical and basilar dendritic compartments of CA1 pyramidal neurons: synaptic tagging is compartment restricted. J. Neurosci. 26(1):256-64.
Etkin A, Alarcón JM, Weisberg S.P, Touzani K, Huang Y-Y, Nordheim A and Kandel E.R. (2006) A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron. 50(1):127-143.

Alarcon JM, Hodgman R, Theis M, Huang Y-S, Kandel E.R. and Richter J.D. (2004) Selective modulation of some forms of Schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene. Learning & Memory. 11:318-327.