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Juan Marcos Alarcon, PhD

Assistant Professor

Department of Pathology, Division of Neuroscience

Office location: 4-113

Lab Tel: (718) 221- 5325

Office Tel:(718)613-8348

Fax: (718) 270-3313

e-mail: juanmarcos.alarcon@downstate.edu

 

 

Research Interest Summary

Understanding how the brain changes with experience is a fundamental question in neuroscience. Our research projects attempt to address this question by characterizing how neuronal and synaptic circuit function changes by experience-driven neural activity.

 

Learn more about our laboratory at: www.alarconlab.com

Research Questions

  • How are memory experiences organized within neural ensembles and synaptic circuits?
  • What processes and mechanisms underlie the organization of a memory?
  • How does the organization of a memory evolve over time?
  • How do new memory experiences shape an extant memory organization?

Selected Publications

  • Arora K, Sequeira JM, Hernández AI, Alarcon JM, Quadros EV. (2017) Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse. PLoS One. e0177156. PMID: 28545069 PMCID: PMC5436650 DOI: 10.1371/journal.pone.0177156
  • Pavlowsky A, Wallace E, Fenton AA, Alarcon JM. (2017) Persistent modifications of hippocampal synaptic function during remote spatial memory. Neurobiology of Learning and Memory. PubMed PMID: 27568918.
  • Allen KD, Gourov AV, Harte C, Gao P, Lee C, Sylvain D, Splett JM, Oxberry WC, van de Nes PS, Troy-Regier MJ, Wolk J, Alarcon JM, Hernández AI. (2014) Nucleolar integrity is required for the maintenance of long-term synaptic plasticity. PLoS One. (8):e104364. doi: 10.1371/journal.pone.0104364. PMID: 25089620 PMCID: PMC4121280
  • O'Reilly KC, Alarcon JM, Ferbinteanu J. (2014) Relative contributions of CA3 and medial entorhinal cortex to memory in rats. Frontiers Behavioral Neuroscience. 28;8:292. doi: 10.3389/fnbeh.2014.00292. PMID: 25221487 PMCID: PMC4148030
  • Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD. (2013) Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology. Nature Medicine. doi: 10.1038/nm.3353. PMID: 24141422 PMCID: PMC3823751
  • Pavlowsky and Alarcon, J.M. (2012) Interaction between Long-Term Potentiation and Depression in CA1 Synapses: Temporal Constrains, Functional Compartmentalization and Protein Synthesis. PLoS One. 7(1):e29865. PMID: 22272255 PMCID: PMC3260185