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Department of Otolaryngology - Research Report

Ongoing Research Projects

Joseph R. McPhee, PhD

  1. Molecular Genetic Basis of human Keloid Formation - The formation of keloid in humans has a genetic component. Revelation of the underlying genetic basis of keloid formation will provide insight into the mechanism of keloid formation and its eventual treatment. My current research involves gene screening for abnormal expression. Preliminary data suggests a specific signal transduction pathway. Future studies will include further clarification of the mechanism of the disease.
  2. Human Vomeronasal Organ Gene Expression - There is considerable controversy over whether the human vomeronasal organ has maintained its functionality. By looking at the pattern of gene expression in excised vomeronasal organs, I hope to determine whether the pattern of gene expression is consistent with functioning sensory tissue.