Faculty Mentors and Their Research Interests

Molecular analysis of gene expression in the developing chick heart, specifically the genetics or "switch on" of two cardiac-special genes and two skeletal muscle-specific genes during critical stages of development. Collaborates on projects involved in genetic analysis (DNA fingerprinting) of mycobacterium tuberculosis.

Biogenesis of angiogenic factors and their roles in cardiovascular disease and cancer. Mechanism of chaperone-dependent protein folding and translocation into organelles.

Studies on the early inflammatory response in influenza infections. Mucosal immunity and the role leukocytes, epithelial cells and/or cytokines play in this process.

Molecular mechanisms of intestinal lipoprotein assembly.

Create and use mouse models (transgenic, gene knock-out) for the studies of sphingomyelin (the second abundant phospholipid in the circulation system) metabolism and atherosclerosis. Use of transgenic approach to perform functional studies of two plasma lipid transfer proteins, phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP).

Investigation of molecular mechanisms underlying cellular homeostasis by studying the role of phosphorylation/dephosphorylation systems in platelet function; mechanisms of platelet activation by stimulatory antibodies directed against novel platelet membrane glycoproteins; and collaborative clinical studies investigating the role of platelet-activating factor (PAF) in pediatric NEC, PAF in learning and memory, and abnormal platelet activation mechanisms in kidney dysfunction.

Study the role of the hippocampus in navigation, learning and memory, analyzing single-cell recordings from awake behaving rats. Study the relationships between the animals position in space, the animals experience and the firing of target cells. Other technical approaches involve analysis of navigation, the study of evoked potentials and the study of the effects of drugs or hormones on neuronal firing properties.

Effectiveness and learning enhancement of alternative approaches to instruction are being investigated in the anatomical sciences. This includes instructional materials as well as practices.

Study of mechanisms by which interferons regulate expression of genes and their effects on sensitivity to virus infection and mitochondrial function.

Extracellular matrix and integrin-regulation of epithelial cell surface polarity development. Signal transduction mechanisms modulating tight and adheren junction assembly junction.

The imaging surface of the retina is mapped point for point onto the visual centers of the brain, providing the brain with a coherent view of the visual world. The formation of these visuotopic maps, which are essential for normal vision, is being studied during development and in models of optic nerve regeneration.

Molecular mechanisms in cardiac development.  Signal transduction pathways and transcription adaptation in myocardial hypertrophy and ischemia. The role of obesity and the inflammatory response, as major contributors in the development of chronic cardiovascular diseases, such as, cardiac hypertrophy, myocardial ischemia, and heart failure.

Richard Feinman, PhD (x2252)

Mechanism of action of proteolytic enzymes and their inhibitors. Computer models of operant conditioning.

Miriam H Feuerman, PhD (x1258)

Molecular mechanism that separates controlled normal growth from carcinogenesis. Study regulation of gene expression in liver regeneration and tumorigenesis.

Gregory Gick, PhD (x1265)

Investigation of the molecular mechanisms underlying regulation of mammalian Na,K-ATPase subunit gene expression in response to hormones and ionic stimuli.

Alan Gintzler, PhD (x2129)

Biochemical basis of narcotic addiction. Sex steroid modulation of intrinsic pain attenuating systems. Signal transduction and narcotic addiction.

Richard Kream, PhD (x6367)

Investigation of the role of inhibitory and excitatory neuropeptides in relieving acute and chronic pain. Development of novel chimeric peptides containing functional domains of an endogenous opioid peptide and the tachykinin substance P. The role of chimeric peptides in mediating analgesia without tolerance.

Mary Makowske, PhD (x3991)

Protein kinase C is a family of homologous isoenzymes involved in many signal transduction pathways. Study the structure of these enzymes and how they recognize their target substrates.

Julie Rushbrook, PhD (x2647)

Structural characterization of fast myosin heavy chain isoforms associated with development and muscle fiber differentiation. Characterization of the 4 nonidentical subunits of mammalian mitochondrial NAD+ isocitrate dehydrogenase and 3-D analysis. Characterization of various human serum proteins associated with disease.

Alfred Stracher, PhD (x1256)

The molecular basis of neuromuscular degeneration and the role of thiol proteases in this process using protease inhibitors as therapeutic agents. Cytoskeleton structure with particular emphasis on the role of phosphorylation in regulating the interaction of actin with platelet filamin.

Dalton Wang, PhD (x1260)

Using garter snakes as a model for signal transduction in vomeronasal systems.

Edward V. Quadros

Molecular, genetic and biochemical aspects of Vitamin B12 metabolism. Purification and cloning of vitamin B12 binding proteins and their receptors. Transcobalamin II and the receptor for Transcobalamin II-Cobalamin as targets for new cancer therapeutics.

Christopher U Hellen, PhD (x1310)

The mechanism of cap-dependent initiation of translation in eukaryotes. Analysis of RNA-protein interactions that mediate initiating of translation by internal ribosomal entry on eukaryotic viral mRNAs, using hepatitis C virus and Encephalomyocarditis virus mRNAs as models.

Tatyana Pestova

Mechanism of initiation of eukaryotic protein synthesis.

Maureen V McLeod, PhD (x3321)

Signal transduction mechanisms that regulate exit from the mitotic cell cycle. Control of protein kinase activity in the stress response.

Donald R Mills, PhD (x1781)

Studying the conformation of messenger RNA as it relates to the regulation of protein synthesis. Also examining RNA protein interactions.

Camilo A Parada, PhD (x1143)

Mechanism(s) by which the HIV-encoded Tat protein, in conjunction with cellular factors, enhances transcription elongation from the HIV-1 promoter. Exploration of the contribution of Tat and cellular factors to HIV-1 transcription re-initiation, transcription through nucleosomes, and mRNA processiing

Christopher A J Roman, PhD (x1143)

Lymphocyte development and and renal cell carcinoma.  We study transcription factors, cytokine pathways, and antigen receptor complexes that are important for lymphocyte development, the immune response, leukemia/lymphoma, and/or renal cancer, using transgenic/knock-out mouse models, primary mammalian cell culture systems, and somatic gene inactivation/retroviral transduction approaches.

Haseeb A Siddiqi, PhD (x1610)

Host-parasite interactions and mechanisms of pathogenesis and immunity in schistosomiasis; reproductive biology of schistosomes and mechanisms of chemoattraction in schistosome males and females.

Fredric C Volkert, PhD (x2933)

Mechanism of mitotic partitioning of yeast nuclear plasmids; control of type 1 protein phosphatase activity; using yeast cells as a model for human folate transport; activities of human Fragile X mental retardation protein.

Virginia M Anderson, MD (x1292)

Morphologic alterations in pediatric and perinatal disease including the placenta in HIV disease, congenital malformations expecially congenital heart disease.

Constantine Axiotis, MD (245-5371)

The expression of the multidrug resistance gene (MDR-P-glycoprotein) in human tumors; and the molecular pathology of breast cancer.

Randall L Barbour, PhD (x1661)

Development of real-time functional imaging technologies for early disease detection, monitoring response to therapy and evaluation of normal tissue functioning.

Patrick C Chen, MD (x1667)

Assess acetylcholinesterase stain and other methods in the diagnosis of Hirschsprung's disease. Using immunohistochemical reagents for pathological diagnosis, assessing the usefulness of the reagents.

Helen G Durkin, PhD (x1295)

Studies of IgE responses of long term survivors with HIV-1 disease. Role of gut associated lymphoid tissue (GALT) in generation and suppression of IgE responses in humans (allergic, HIV+) and rodents. Attempting to determine how IgE responses can be eliminated, without interfering with humoral antibody responses of other isotopes (IgM, IgG, IgA) or cell mediated immune responses. Studies focus on role of bacterial cell wall components, cytokines, especially IL-6, and neuropeptides, especially substance P, in isotype specific suppression of IgE responses.

Elizabeth S Gloster, MD (x1681)

Review of the Downstate and Kings County experience with red cell alloimmunization in sickle cell patients, clinical aspects of transfusion reactions and the off-label use of recombinant factor VIIa.

Susan RS Gottesman, MD/PhD (x1661)

Studying the changes in the immune system during normal aging in mice. Study the characteristics of lymphoid malignancies using patient material. Will be setting up a tumor bank.

Joan Howanitz, MD (x4520)

Clinical chemistry including hemoglobinopathies; critical results for sodium and cardiac marker utilization.

Peter Howanitz, MD (x4520)

Quality of care; chemical pathology.

Josef Michl, MD (x1643)

Study of the cells involved in host defense mechanism against infectious agents and tumors, and of carcinogenesis in the exocrine pancreas in animals and man: Establishment of novel in vitro and in vivo disease models for the identification of unique disease-specific molecules for the development of early diagnostic approaches and effective therapeutic tools for this disease.

Suzanne Mirra, MD (x1291)

Neuropathology of Alzheimer's disease and other neurodegenerative disorders.

Maja Nowakowski, PhD (x2206)

Systemic and local pulmonary immunity in lung diseases, including HIV-1 disease, tuberculosis and chronic inflammatory disease. The role of macrophage-derived nitric oxide in lung diseases, including asthma, HIV-1 disease, tuberculosis, and chronic inflammatory disease.  Effects of virus infection on macrophage physiology and immune functions.

Martin J Salwen, MD (x1689)

Define outer limits of laboratory test analyses.  Develop programs for interpretive analysis of clinical laboratory data using rule-based logic and pattern analysis. Programs have incorporated modules for instruction in testing strategies for differential evaluation of patients. Programs have been developed for Erythocytosis. Strategies for rapid bacterial identification in sepsis.

Bella T Altura, PhD (x2205)

Study drugs and ion (particularly magnesium) effects on the cardiovascular system, in intact animals, in vitro heart and blood vessels and single cells via culture. Designs and participates in human studies centering on importance of ionized magnesium in disease processes.

Burton M Altura, PhD (x2194)

Focus on magnesium in cardiovascular biology, both in animals and human subjects. Involved in new diagnostic and prognostic test development, and new medical devices. Studies biochemical and molecular physiological processes in atherogenesis and stroke. Primary cultured vascular smooth muscle, endothelial and glial cells are used.

Vahe E Amassian, MD (x3900)

Magnetic or electrical transcranial stimulation of human (or animal models) is used to analyze motor and perceptual functions. Lateralization is sought including differential effects on the immune system. Animal models of human disorders (e.g. spinal cord trauma) are used to elucidate the basic explanations of the impaired function.

Peter J Bergold, PhD (x3927)

Interested in the role of gene expression in the pathophysiology of neuronal disorders, particularly stroke and epilepsy.

John Chapin, PhD (x1339)

Develop and utilize technologies for neurophysiologically recording from large populations of neurons in sensory and motor areas of the brain. Computer techniques for online extraction of coded information in the brain are used to control external devices such as robot arms.

Diana L Dow-Edwards, PhD (x3987)

Use neuro-imaging and neuropharmacologic techniques to study the effect of drug exposure during brain development. The overall hypothesis is that the actions of drugs typically cocaine or similar drugs, alters the functional maturation of the brain.

David J Erlij, MD/PhD (x2243)

Hormonal regulation of membrane transport.

Steven E Fox, PhD (x2177)

Study the EEG theta rhythm in rats to understand how it influences information processing by the hippocampus. Theta rhythm occurs during movement and is paced by cholinergic neurons that project from the medial septal nuclei to the hippocampus. The degeneration of these basal forebrain cholinergic neurons is probably the cause of the memory deficit of Alzheimer's patients.

Ellen Hsu, PhD (x1154)

Immunoglobulin gene expression and regulation.

Anthony Sica, PhD (x1232)

Chronic monitoring of physiological variables (EEG, EKG, sleep) in a developing animal model (swine). Recordings of the sympathetic and respiratory rhythm generators (output) during postnatal development. Effects of autonomic denervation of the heart on cardiovascular reflexes during development. Examination of postnatal development of autonomic regulation using different techniques including immunocytochemical.

Douglas S. F. Ling, Ph.D. (x4631)

The potentiation of GABAergic inhibition by nootropic (cognition-enhancing) drugs induced by changes to inhibitory cell function.  Injury-induced changes in synaptic function that lead to epileptiform activity, using a model of acute neuro-trauma

William Lytton, MD (x1339)

Modeling electrophysiological processes pertinent to epilepsy and modeling abstract neural networks to understand recovery from stroke and the basis of cognitive processes. Development and application of new conceptual and technical tools to integrate the top-down techniques of artificial neural networks with the bottom-up techniques of detailed neural modeling.

Hillary Michelson, PhD (x3182)

Studying the connectivity of the inhibitory circuit in the hippocampus and the maturation of GABA mediated inhibition.

Robert Muller, PhD (x1151)

Physiology of learning and memory; measurements of place cells in rats and genetically-altered mice; pharmacological effects on place cells.

Nicholas Penington, PhD (x3399)

Study the regulation of nerve cells in the brain that release the neurotransmitter (5-HT) and focus on central serotonergic (5-HT) neurotransmission and neuropharmacology. Studies of the molecular level on the signal transduction pathways in these nerve cells and investigations of how drugs interact with a single receptor system, capable of modulating two different ion channels simultaneously

Katherine L Perkins, PhD (x2772)

Synaptic transmission in the hippocampus - interneuron networks, epileptiform activity, depolarizing GABA response.

Alan P Rudell, PhD (x1150)

Electrical brain responses to recognizable images (words, pictures, faces) are recorded and related to acquired perceptual skills (e.g. reading ability).

Todd Sacktor, MD (x3933)

The role of protein kinase C isozymes in long-term synaptic plasticity (LTP & LTD), and their relationship to memory.

Sheryl S Smith, PhD (x1339)

Modulation of hippocampal and olivo-cerebellar circuits by neuroactive steroids. Currently investigating steroid-induced changes in synaptic physiology induced by alterations in GABAA receptor subunit composition. Behavioral correlates, such as anxiety and seizure susceptibility are also under investigation. Possible clinical relevance for PMS and catamenial epilepsy.

Armin Stelzer, MD (x3873)

Intracellular regulation of ligand-gated receptors. Activity-dependent modification of the inhibitory circuit.

Mark Stewart, MD/PhD (x1148)

We study isolated neurons, brain slices, and intact animals to explore cellular and circuit properties of subicular and other parahippocampal neurons that contribute to seizure generation and spread within these cortical areas. We use intact animal models to study the spread of seizure activity from the 

limbic cortices into other brain areas and the impact of seizure spread on autonomic and immune system function.

Henri Tiedge, PhD (x1370)

Sorting and intracellular targeting of neuronal RNA. Local protein synthesis in neurons. Regulation of gene expression in neurons by trans-synaptic activity.

Roger Traub, MD (x)

Cellular mechanisms of neuronal network oscillations and seizures.

Mario Vassalle, MD (x1158)

The electrical function of the heart is studied using different techniques, from transmembrane recording to voltage clamping. Normal and abnormal automaticity is studied in different cardiac tissues. Ionic mechanisms and their control are studied in relation to impulse formation under normal and abnormal conditions.

Keith Williams, PhD (x4610)

Structure, function, and regulation of glutamate receptors.

Robert KS Wong, PhD (x1339)

Transmitter modulation of hippocampal neuronal network mechanisms of epileptogenesis.

Alexandru Apostol, MD

(X:1910 or 2530)

The effect of magnesium sulfate on neonatal outcome. Protocol in development.

Audree Bendo, MD (x3764)

Evaluation of the safety and efficacy of various anesthetic agents (thiopental, propofol, etomidate) in the management of critically ill neurosurgical patients. Study of tissue thromboplastin levels using cell saver in neurosurgical patients.

James Cottrell, MD (x1935)

Studying the ability various anesthetic agents have to protect the brain during and after surgery. Perform both in vivo and in vitro studies and are most interested in the mechanisms of brain protection.

Jean Carchaflieh, MD (x3269)

Examine the mechanisms of anoxic brain damage using the in vitro rat hippocampus (with Dr. Kass). Risk factors for development of respiratory failure after cardiac surgery (with Dr. Worah).

Joshua Greenspan, MD (780-1663)

Impact of spinal cord stimulation on quality of life in patients with chronic refractory coronary angina. Effect of spinal cord stimulation on chronic ischemic pain and functional ability in patients with peripheral vascular disease.

Ira Kass, PhD (x1709)

Examine the mechanisms of anoxic brain damage using the in vitro rat hippocampus. Measure electrophysiological parameters and ATP, Ca, Na and K+ levels. Emphasis is on how anesthetics effect anoxic brain damage.

Helen Lauro, M.D.

(780-1707)

Studies related to pediatric anesthesia- Propofol infusion syndrome in pediatric patients undergoing MRI. Protocol in development.

Ketan Shevde, M.D.

(x 1563)

Clinical outcome following cardiac surgery.  Laboratory investigation of cardiac ischemic model._

Rebecca S Twersky, MD (780-1350)

Preoperative Beta-Blocker Study-Prophylactic perioperative beta-blocker use in clinical practice (with Dr. John Fiadjoe).  Perioperative use of ACE Inhibitors in ambulatory patients (with Dr. Ashraf).

Gerald Wolf, MD (x1934)

Operating room fire safety.

Hilary Baldwin, MD (x1229)

Clinical trials of various agents affecting keloids and hypertrophic scars. Clinical trials in alopecia.

Neil Brody, MD/PhD (x1229)

Isolation and characterization of molecules made by tumor cells that alter immune responsiveness or enhance tumor survival. Studying effects of sunlight on immune system.

Sharon Glick, M.D

Projects in pediatric dermatology

Edward R Heilman, MD (x1229)

Prognostic indicators of malignant melanoma.

Wei-Li Lee, PhD (x2170)

Using an in vitro leukocyte-endothelial cell model system to evaluate potential anti-inflammatory properties of compounds with special regard for the skin. Studying the effect of antibiotics and anti fungals on leukocyte activation, cell morphology and cell functions.

Eve Lowenstein, M.D

Projects in dermatology.

Alan R Shalita, MD (x1229)

Clinical trials of various agents for treatment of acne and related disorders. Microbiology and inflammation in acne.

Bonnie Arquilla
arquibon@aol.com

Ian DeSouza
juicemd@yahoo.com

Christopher Doty
chris@doty.net

Antonia Hipp
Antonia424@earthlink.net

Jeffrey Hom                                    
jhom@msn.com

Seth Manoach
Seth.manoach@downstate.edu

Rajesh Mittal
Rmittal5@yahoo.com

Lorenzo Paladino
L_paladino@msn.com

Peter Peacock
peacock@nyc.rr.com

James Sadock
James.sadock@gmail.com

Richard Sinert
Nephron1@bellatlantic.net

Jonathan Wasserman
wassj@yahoo.com

Shahriar Zehtabchi
zehtab@yahoo.com

Dr. Hanna Aghabi 393-0300

Early Cancer detection in primary care:skin, colon and breast; Dermatologic procedures in Family Medicine

Richard Sadovsky, MD (x2441)

Studies reviewing the ability of a clinical office to enroll entire families and to use entire families as the focus of treatment; effective medical writing skills; effective patient education; evaluating patient understanding of a disease. Sexual Health of the Older Patient

Pamela Sass, MD (x2442)

Effectiveness of school based directly observed therapy for the prevention of tuberculosis.

Miriam Vincent, MD (x2443)

Appropriateness and standard of care for ambulatory NIDDM (Non-Insulin Dependent Diabetes Mellitus); preventive care in family practice (MTV); alcohol and substance abuse screening in family practice; influenza and pneumococcal vaccination: compliance, barriers, practice. Osteoporosis screening, evaluation and treatment in primary care

Diabetic Neuropathy (screening, diagnosis and treatment).

Dr. Gloria Mtomboti x3264

Vaginitis, STD's in Primary Care, Thyroid Disease in Primary Care

Dr. Margaret Donat x2560

Preventive Care in Family Medicine; Immunizations and Complications in Primary Care

Dr. Aneela Hussain x3627

Headache and Cancer Prevention in Primary Care; Diabetic Neuropathy

Abha Agrawal, MD (718-245-3980)

Medical informatics and the use of technology in clinical care, including design, development and evaluation of clinical information systems.

MaryAnn Banerji MD (x1542, x1698)

Diabetes and cardiovascular disease, diabetes prevention, insulin resistance and insulin secretion, HIV and diabetes, endocrinology.

Olcay Batuman, MD (x1553)

Molecular mechanisms that regulate angiogenesis (new blood vessel formation) in multiple myeloma (a common blood cell tumor). Molecular mechanisms which regulate behavioral response to stress.

Mohamed Boutjdir MD (718-836-6600 x6070)

Autonomic regulation of native and heterologously expressed ion channels, intracellular signaling, arrhythmias during ischemia and hypertrophy. Molecular and cellular mechanisms of congenital heart block in infants born to mothers with autoimmune diseases.

Erdal Cavusoglu (x3273)

Analysis of FIIR/JAM in patients undergoing coronary angiography.

Luther Clark, MD (x1568)

Cardiovascular effects of thiazolidinediones; Effect of HIV infection on stent restenosis rates; Predictability of the metabolic syndrome for coronary artery disease

Paul Dreizen, MD (x1155)

Molecular mechanism of actomyosin cross-bridge cycle in skeletal and cardiac muscle and its regulation by tropomyosin. NMR relaxation studies and molecular modeling of protein interactions using model systems.

Eli A Friedman, MD (x1584)

Epidemiology of diabetic kidney disease. Blocking diabetic vascular complication.

Donald A Gerber, MD (x1455)

Interaction between lupus-inducing drugs (e.g. hydralazine and procainamide) and leukocyte oxidants (i.e. hypochlorite and hydrogen peroxide) and the effect of this interaction on protein structure.

A Ross Hill, MD (x1770)

Clinical studies on TB, e.g. retrospective case series and prospective study involving patients in DOT (directly observed therapy) program. Longstanding interest in respiratory physiology (mechanics, resp. muscles, control of breathing).

Rauno O Joks, MD (x2156)

Anti-inflammatory  properties of tetracycline antibiotics 2. Role of complement proteins in allergic diseases

Martin Kramer, MD (x3996)

Clinical studies in infection control at Kings County Hospital.

David Landman, MD (x3790)

Investigations include molecular epidemiology of nosocomial infections and studies involving the mechanisms of antibiotic resistance; evaluations of the activity of new investigational compounds and also conducted.

Sheldon Landesman MD (3034)

Prospective study of HIV infected pregnant women and their offspring, the natural history of perinatally acquired HIV, the effect of retrovirals on cardiac function and the development of mitochondrial syndromes in children.

Jason Lazar MD (x1568)

Alcoholic cardiomyopathy; effect of action potential duration in ischemia.

William M McCormack, MD (x1432)

Evaluation of diagnostic tests for and treatment of sexually transmitted and other genitourinary infections.

Jonathon Marmur MD (x8982)

Anticoagulation in atrial fibrillation and patients with prosthetic valves; Effect of Iib/IIIa receptor inhibitors; Effects of pioglitazone vs. glimepiride on rate of progression of atherosclerosis in diabetes mellitus; the effect of aspirin assay in patients undergoing angiography

Allen J Norin, PhD (x2516)

Xenotransplantation of genetically altered swine to primates. Receptor - ligand interactions involved in cytolytic lymphocyte destruction of tumor cells and/or organ grafts.

Louis Salciccioli MD (x1568)

The use of brain natriuretic peptide in assessing the severity of coronary artery disease

Man Seok Oh, MD (x1565)

Whole body acid-base balances.

John Quale, MD (x)

Investigations include molecular epidemiology of nosocomial infections and studies involving the mechanisms of antibiotic resistance; evaluations of the activity of new investigational compounds and also conducted.

TK Sreepada Rao, MD (x1394)

AIDS and kidney disease; erythropoietin in kidney disease.

William B Solomon, MD (x1333)

Protein:DNA interactions; Cloning of novel hematopoietic mRNAs.

Steven M Weiss, MD (x4181)

Investigating the possible relationships between Chlamydia pneumonia infection and atherosclerosis and asthma.

Brian J Anziska, MD (x2502)

Comparison of neurology undergraduate education in different medical schools using parameters such as over-night calls, and examination modalities.

Chun Bai (x2883)

Sleep studies

Satyakam Bhagavati, MD (x2041)

Analyzing the biological effects of abnormal triplet repeats in myotonic dystrophy and other genetic diseases, and, using ribozymes as a tool for functional analysis and therapy.

Ivan Bodis-Wollner, MD (x2975)

Vision and visual cognition suffer in Dopaminergic deficient states, such as in Parkinson's disease. Using pharmacological agents, these studies evaluate electrophysiological neural network properties of dopaminergic circuits mediating vision and visual cognition.

Geetha Chari (x2959)

Epilepsy clinical studies

Roger Q Cracco, MD (x2051)

Magnetic stimulation of Nervous System.

Joan Cracco, MD (x2035)

Mechanisms of long term potentiation.

Howard Crystal, MD (x2748)

Cognitive changes in HIV, Genetics of substance abuse in HIV, Computational models of working and procedural memory.

Arnold E Eggers, MD (x2059)

Immunotherapy of solid tumors using vaccine of autologous skin fibroblasts linked to adjuvant muramyl dipeptide.

Roger W Kula, MD (516-570-4400)

Clinical trials in therapy of Neuromuscular diseases. Neurotrophic agents in motor neuron diseases Myoprotectant agents in dystrophic myopathies

Paul J Maccabee, MD (x2430)

Physical modelling, in-vitro studies of nerve excitation using neuromagnetic stimulation. Developing clinical methods to detect abnormalities in the cauda equina and also the entire neuroaxis.

Alexander Mauskop, MD (935-9666)

Ionized magnesium and headaches.

Lisa Merlin, MD (x3957)

Hippocampal electrophysiology: examination of the role of metabotropic glutamate receptors in seizure production and epileptogenesis, with the aim to develop ways to prevent epilepsy in at-risk patients and suppress seizures in refractory patients.

Herman Moreno MD (x1338)

Use of fMRI and electrophysiology to study brain metabolism in neurodegenerative disease

Sophia Sharfstein MD (x2035)

Stroke studies

Helen Valsamis, MD (x1356)

Investigations on  the prevention of post-traumatic epilepsy

Marketa Vyskocilova (x4792)

Epilepsy clinical trials

Krystyna Wisniewski, MD/PhD (x2042)

Study the pathogenesis and etiology, and new diagnostic tests, neurogenetic diseases; in particular progressive neurological disorders, neurometabolic diseases, e.g. neuronal ceroid lipofuscinosis (NCL), Down Syndrome, Fragile X syndrome and other developmental disabilities associated with brain abnormalities, e.g. malformations.

Ethan Benardete (4335)

Molecular Mechanisms of Neuronal Protection

Ovadia Abulafia, MD (x2057)

Thrombophilia in gynecologic malignancies; Albumin levels as prognosticators of risk in gynecologic malignancies; Adequacy of hysterectomy in patients with positive endocervical curettage; incidence of BRCA1 and BRCA2 in African-American women with gynecologic cancer.

Vajaya Nacharaju, PhD (x2064)

Estrogen and progesterone metabolites in urine and saliva, 11beta steroid dehydrogenase and aromatase in endometrial carcinoma

John Rasweiler, PhD (x2057)

Angiogenesis in the mammalian endometrium

Theresa Brevetti MD (x1962)

Ocular blood flow/glaucoma.

Monica Dweck, MD (x1961)

Lacrimal and Orbital disease.

Jeffrey Freedman, MD/PhD (x1961)

Elucidation of the mechanisms of inflammatory fibrosis in glaucoma.

Douglas Lazzaro, MD (x3380)

Cornea research.

Eric Shrier MD (x1962)

Retina/Vitreous research

Janine Smith MD (x1962)

Pediatric Ophthalmology and Strabismus.

Arthur Wolintz, MD (x1961)

Ocular Manifestation of neurologic disease.

Andrew Merola, MD (x2039)

Clinical studies.

Enrique Monsanto, MD (x1309)

Hand surgery - clinical studies.

Charles R Spero, MD (x2055)

Pediatric orthopedic surgery.

Henry M Tischler, MD (x3200)

Joint replacement/reconstruction.

William Urban, MD (x2055)

Sports medicine.

Nira Goldstein, MD (x1638)

The diagnosis of pediatric obstructive sleep apnea. Impact of tonsillectomy and adenoidectomy on child behavior.

Gady Har-El, MD (x1638)

Head and neck cancer. Surgical approaches to skull base tumors. Reconstructive techniques after head and neck cancer surgery. Deep neck infections.

Jessica W Lim, MD (x1638)

Effect of endoscopic sinus surgery and middle turbinate positioning on olfaction. Tracheotomy in the elderly patient.

Joseph R McPhee, PhD (x2350)

Molecular genetic basis of otosclerosis. The use of high frequency otoacoustic emissions in the monitoring of early-stage ototoxicity. Collagen remodeling and keloid formation. Stromelysin expression in head and neck carcinoma.

Richard Rosenfeld, MD (x1638)

Quality of life research. Meta-analysis. Otitis media.

Neil Sperling, MD (x1638)

Distortion product otoacoustic emissions applied to hearing loss. Quality of life aspects of chronic infectious ear disease.

Stacy Blain

Cell cycle progression, focusing on the cyclin cdks and their inhibitors, Cip/Kips,

Shirley Chang

 Electron microscopy  of pediatric kidney disease

Margaret Clark-Golden, MD (x2132)

Risk factors for pediatric injury, both intentional and non-intentional; lead poisoning; nutrition.

Margaret R Hammerschlag, MD (245-4074)

Current research is concentrated on the epidemiology, immunology, diagnosis and treatment of infections due to Chlamydia pneumoniae. This includes investigation of the relationship to reactive airway disease, at cytokine production, mouse model of C. pneumoniae infection and atherosclerosis, reactive airway disease. Antibiotic treatment trials. Diagnosis and treatment of C. trachomatis infections in infants and adolescents. Sexually transmitted diseases and sexual abuse.

Robert Karp, MD (245-3612)

Nutrition, lead poisoning: relation of immunization status to physical growth, hemotologic status and lead level.

Scott T Miller, MD (x1692)

Clinical/psychosocial aspects of pediatric sickle cell disease.

Madu Rao, MD (x1524)

Asthma: epidemiology, mortality trends in Brooklyn. Sleep: obstructive sleep apnea in children - demographics, pulmonary hypertension lung physiology in sicklers prone to lung disease (consultant for national cooperative study).

Sreedhar Rao, MD (x1692)

Clinical expression of big parvovirus on children with sickle cell disease and in children with AIDS. Pneumococcal antibodies in children and adolescent with sickle cell disease. Role of booster immunizations with pneumococcal vaccine. Radionuclide imaging and MR imaging of bones in sickle cell disease.

Amy Suss, MD (x1625)

Hepatitis B&C in adolescents. New treatments for chlamydia in adolescents. Suicide attempts in adolescents.

Jack A DeHovitz, MD (x1069)

Prospective studies of HIV-infected women

Joseph Feldman, DPH (x1080)

Prognosis of breast cancer; natural history of HIV infection; cancer epidemiology; epidemiologic methods.

Pascal J Imperato, MD (x1056)

Clinical outcomes research. Population studies.

Judith H LaRosa, PhD (x3204)

Public health aspects of women's health, cardiovascular disease, community health, and sex/gender differences in health.

Allen D. Spiegel, PhD (x1072)

Patient-physician-community communications; medical sociology; community mental health; strategic health planning; risk management.

Bernice Porjesz (x2024)

Mathematical models of brain function. Genetics of brain function. Neurophysiology in humans. Genetic study of alcoholism.

Michael Berzofsky, PhD (x2004)

Research is focused on change in psychotherapy in brief hospital treatment. Focus is on how patients engage or resist the treatment process to subjectively describe their inner world and experiences.

Carl Cohen, MD (287-4806)

Research on anxiety and depression of older Afro American and Afro Caribbean’s living in Brooklyn. Evaluation of minority dementia patients and caregivers. Schizophrenia and aging comparison of Afro-Americans and Caucasians living in nursing homes.

Jeremy Coplan, MD (x2022)

Research on animal models of anxiety disorders.

Hartvig Dahl, MD (x1452)

Developing systematic methods for finding fundamental repetitive and maladaptive emotion structures (frames).

A dynamical systems approach to the study of perceptual mechanisms underlying cognitive development at one year in typical and atypically developing populations. Cross-disciplinary investigations of maternal multisensory communication and infant auditory-visual perception as predictors of language outcomes in full-term and preterm infants.

Leonard A Rosenblum, PhD (x1447)

The effects of different rearing paradigms on subsequent behavioral and neurochemical functioning are studied in several species of nonhuman primate; assessments include social, affective and cognitive measures, incorporating behavioral observations and computer-based video tasks, and response to pharmacological probes and treatments, during development and in follow-up periods several years following treatment.

Peter Weiden, MD (x4675)

Studying the effectiveness of new antipsychotic medications in the treatment of schizophrenia. Research on medication noncompliance in schizophrenia.

Kwang N Choi, MD (x1591)

Continuous infusion chemotherapy with hyperfractionated irradiation for locally advanced cancers. Combined chemotherapy and irradiation in cancer treatments.

Bozidar Djordjevic, PhD (x1250)

Modification of radiation response (survival) by administration of chemicals (chloroquine) and mild hypothermia (41C). Differences between various cell types as to response to combined modalities (radiation, heat, and mild hypothermia). Development of carcinogenicity test systems.

Fazal Hussain, MD/MPH (x1594)

Time, dose, and delivery of total androgen suppression in prostate cancer. Role of race and other prognostic factors in cancer. Cell sensitizer and radiotherapy in cancer treatment.

Christopher Lange, DPhil (x1050)

Cellular basis of organismal radiation: lethality and aging. Cellular radiation lethality in terms of DNA DSB repair kinetics. Chromosome structure-DNA organization. Physical chemical/biophysical methods for DNA size measurement.

Marvin Rotman, MD (x2181)

Clinical trials with the Radiation Therapy Oncology Group. Gynecology Oncology Groups: chemotherapy and radiation.

Eddy Dunn, MD (x1902)

Intraoperative sentinel node analysis by nuclear medicine agents (monoclonal antibodies). Evaluation of tinnitus and evaluation of migraine with cerebral perfusion scintigraphy.

Brian Gale, MD (x1603)

Medical informatics. Intraoperative sentinel node analysis by nuclear medicie agents (monoclonal antibodies). Ultrasonography of the endometrium. Computers in medicine.

Arash Gohari (x1603)

Cardiovascular imaging

Michael Herskowitz, MD (x1996)

Studying patency of dialysis grafts after thrombolysis. Also studying patency of dialysis grafts after placing metallic stent prosthesis at sites of recurrent stenosis.

Sundeep Mangla, MD (x2111)

Intracranial Aneurysms (imaging, Public Health, therapy); Cerebrovascular Occlusive Disease, Angiopasty and Stenting; Robotics, Endoluminal Diagnosis and Intervention; Cerebral Perfusion (imaging and pharmacology); Population based Screening MRA studies; prospective outcomes research; basic translational research; prospective imaging studies.

Salvatore Sclafani, MD (245-4447)

The study of new technologies, such as embolization, to control traumatic hemorrhage. Evaluation of Corvita stent grafts for abdominal aortic aneurysm repair.

Arnold Strashun, MD (x1632)

Intraoperative sentinel node analysis by nuclear medicine agents (monoclonal antibodies). Evaluation of tinnitus and evaluation of migraine with cerebral perfusion scintigraphy. Scintigraphic evaluation of en bloc cadaveric double renal transplants.

Daniel L Zinn, MD (x2552)

Use of Doppler (Color and Power) in testicular torsion analysis. Medical education through medical and diagnostic imaging.

Harry L Zinn, MD (x1603)

Topics in genitourinary cross-sectional imaging.

Martin Bluth, MD (x6772)

ICAM and selectin mediated leukocyte circulation and migration patterns in inflammation; PBMC regulation of inflammatory diseases; Immunoglobulin regulation in autoimmunity and transplantation.

Joshua Burack, MD (x1981)

Mediastinal trauma; endocarditis; graft infection; socio-economic factors and access to health care in cardiac surgery.

Dale A Distant, MD (x1898)

Immunosuppression in renal transplantation; diabetic uremia.

Lisa S Dresner, MD (x1953)

Critical care; microvascular reactivity.

John G Kral, MD/PhD (x1955)

Insulin resistance metabolic syndrome; obesity, diabetes; adipose tissue; insulin resistance; vagal function.

Theophilus Lewis, MD (x2155)

Nutrition support.

Patricia O'Neill, MD (x1973)

Antibiotic prophylaxis.

James Reilly, MD (x2439)

Mathematical modeling; decision analysis.

Nabil Sumrani, MD (x1898)

Renal transplantation and diabetes.

Michael Zenilman, MD (x1973)

Physiology of pancreatic regeneration; molecular genetics; advanced laparoscopic and pancreatic surgical technique; surgery in the elderly.

Mark Horowitz, MD (x2554)

Clinical research in pediatric urology.

Richard J Macchia, MD (x2554)

The department is engaged in a broad range of clinical research involving all aspects of general and pediatric urology. Topics include various aspects of BPH, prostate cancer, laparoscopic surgery, voiding dysfunction, sexual dysfunction, community outreach/education programs, and other areas.

Samuel R Adams, DVM (x1194)

Improvement of animal resources. Development, improvement and refinement of animal models.

Bruce Scharf, DVM (x1194)

Development of cancer models with cell marking and drug screening; primate behavior; pancreatic cancer.

Alice Herb, JD/LLM (x3780)

Clinical ethics, health law, patient advocacy, research ethics.

Kathleen E Powderly, PhD (x3322)

Ethical and legal issues in HIV disease. Ethical issues for first responders in the era of terrorism; history of medicine; perinatal ethical issues