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Department of Neurology
Herman Moreno, M.D.
Assistant Professor of Neurology
Assistant Professor of Physiology and Pharmacology
Education and training:
Medical School: Universidad de Caldas, Colombia
Postgraduate in Neuroscience: New York University
Neurology Residency: SUNY Downstate
Fellowship in aging and dementia: Columbia University
Board certified in: Neurology and Behavioral Neurology
Our laboratory is interested in normal brain function during the ageing process, as well as the study of neurodegenerative diseases. We study multiple genetically modified mice with conditions that resemble human neurodegenerative disease, mainly Alzheimer's Disease; Down syndrome mice models; mice that express abnormal levels of calcium binding proteins; and combinations of these.
The methods are a combination of functional and structural micro MRI (in vivo mice imaging) with in vitro neuronal-(axon and dendrites) calcium imaging and basic electrophysiology of the hippocampus.
Our main hypothesis is that cognitive deficits in ageing and some neurobehavioral entities are related to altered central nervous system calcium homeostasis, in specific subregions of the hippocampal formation. Since the MRI-techniques (Steady-State Cerebral Blood Volumes) that we have developed in mice can be safely applied to humans, we have started a series of collaborations, imaging humans with a variety of neurocognitive deficits.