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SUNY Downstate Medical Center

Department of Neurology

Movement Disorders

Overview

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The Movement Disorders Division of the Department of Neurology provides clinical care, research and education. The cornerstone of the Division is the Parkinson's Disease and Related Disorders Center. Through this center, research, comprehensive care, and outreach are coordinated to care for people with Parkinson's Disease and Related Disorders, and to advance our ability to understand and treat the condition.

Although patients with movement disorders generally are treated as outpatients, the movement disorders physicians provide inpatient consultation. Resident training is provided, at Kings County Hospital’s Center of Excellence, through resident clinics and electives. Residents have the opportunity to learn Botox injection technique under supervision.  In addition, residents have the opportunity to become engaged in clinical and translational research.

Our Services

  • Diagnosis (or second opinion) of Parkinson Disease, essential tremor, dystonia, or other movement disorder.
    • To do this we perform a detailed history, focused physical and complete neurological exam;
    • As indicated, we may order tests including CT scan, MRI, PET scan, DAT scan, OCT, EMG/Nerve conduction studies, EEG, visual evoked potentials, laboratory tests, pulmonary function tests, speech, GI evaluation for unexpected weight loss, and difficulty swallow evaluation, genetics testing, neuropsychological testing;
  • Education about the diagnosis, and treatment choices.
  • Treatment of movement disorders, newly diagnosed as well as those which have progressed. Treatments we offer or prescribe include:
    • Medications, either taken by mouth, injected or via "patch";
    • Physical therapy, occupational therapy, speech therapy;
    • Botulinum toxin injections for dystonia, sialorrhea (excess drooling), spasticity and other neurologic disorders;
    • Referral of carefully screened candidates for deep brain stimulation.

Research

We are actively engaged in basic research and clinical trials in Parkinson's Disease.  Our current trials are listed below.

Parkinson Study Group (PSG)                       

  • The relationship between levodopa therapy and inner retinal layer thickness by Optical Coherence Tomography (OCT) in patients with Parkinson’s Disease (PD).
  • The goal of this study is to evaluate the relationship between L-dopa treatment and inner retinal layer thickness in PD subjects.    

 

Michael J. Fox Foundation                               

  • Intrinsic Re-Modeling of the Fovea in Parkinson’s Disease.
  • The goal of this research  is to produce a manual of step-by-step instructions for quantifying the foveal pit using SD-OCT (Spectral-Domain Optical Coherence Tomography).

 

Osmotica Pharmaceutical Corp.

  • A Multicenter, Randomized, Placebo-controlled, Double-blind, 26 Week Study to Evaluate the Efficacy and Safety of Amantadine HCl Extended Release Tablets in Parkinson’s Disease Subjects with Levodopa-Induced Dyskinesias.
  • The purpose of this research  is to compare the efficacy and safety of two different dose levels of Amantadine Extended Release tablets to placebo for the treatment of levodopa-induced dyskinesias in patients with PD.

 

Civitas Therapeutics, a wholly owned subsidiary of Acorda Therapeutics, Inc.

  • A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Investigating the Efficacy and Safety of CVT‑301 (Levodopa Inhalation Powder) in Parkinson’s Disease Patients With Motor Response Fluctuations (OFF Phenomena) (SPAN-PD™).
  • Sub-study: Video recording for training and assessment.
  • A 12-Month, Dose-Level Blinded Study Investigating the Safety and Efficacy of CVT-301 (Levodopa Inhalation Powder) in Parkinson’s Disease Patients With Motor Response Fluctuations (OFF Phenomena).
  • Sub-study: Video recording for training and assessment.
  • The studies will establish the usefullness and safety of an investigational drug, inhaled CVT 301, compared with placebo in PD patients suffering from motor response fluctuations (OFF episodes) at home and in the clinic.

Clinic Information

At Kings County Medical Center, twice a month, there is a specialized Parkinson’s Disease and Related Disorders clinic.  The clinic is held the first Thursday and third Wednesday of every month.  Each patient is seen by a resident and evaluated by the attending, Dr. Bodis-Wollner.

Our Team

Our capabilities include two attending physicians, a clinical trials coordinator, research fellows and assistants.