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SUNY Downstate Medical Center

Division of Infectious Diseases

Research

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Research is a strong component of the educational experience of all Infectious Diseases Fellows. Here is a sampling of current research projects currently underway. Please look back frequently for additions.

Any one who is interested in participating in research either as a patient who would like to enroll or someone who is interested in getting research experience can discuss with the contact person listed.



At University Hospital of Brooklyn Department Infectious Diseases in Pediatrics:

The Pediatric HIV/AIDS Cohort Study (PHACS) at SUNY, supported by the NICHD with data and research coordination provided by Harvard's School of Public Health was established in 2006 to address two critical research questions:

What is the long-term safety of fetal and infant exposure to prophylactic antiretroviral chemotherapy? and What are the effects of perinatally acquired HIV infection in adolescents?

The goals of this network are to:

  • Acquire more definitive information regarding long-term safety of antiretroviral agents when used during pregnancy and in newborns
  • Ensure that a mechanism is in place to estimate the upper bounds of risk to children associated with the use of antiretrovirals by their HIV-infected pregnant mothers as recommended in the Public Health Service Guidelines to prevent perinatal HIV transmission
  • Ensure that the follow-up of these populations continues

Our PHACS network participation consists only of The Surveillance Monitoring for ART Toxicities (SMARTT) Study. This protocol also accommodates focused sub-studies.

We recruit study subjects from our different HIV Programs including HEAT, FACES, STAR and SUNY's Department of Obstetrics and have open enrollment for new "dynamic" cases.

Any information needed, please contact Ms Ava Dennie PA, Study Coordinator at Ext 2966 or ava.dennie@downstate.edu or Hermann A Mendez MD Principal Investigator at Ext 2271 or Hermann.mendez@downstate.edu


Hepatitis C Research

Contact brian.edlin@downstate.edu

Dr. Edlin conducts multidisciplinary, community-based research with street-recruited drug users. The goals of this work are to develop a multidimensional understanding of the factors associated with health and illness in these populations, and develop and evaluate policies and interventions to improve their health. Two community-based studies currently underway in New York focus on how and why, despite access to needle exchange, the hepatitis C virus (HCV) continues to spread among persons who inject illicit drugs, and on overcoming the barriers to access to hepatitis C treatment in active drug users. The Swan Project, a study of the clinical, behavioral, virologic, and immunologic characteristics of acute HCV infection among high-risk young persons who inject illicit drugs, is currently underway on the Lower East Side of Manhattan. Choices is a randomized trial of a novel multidisciplinary, integrated care program conducted in collaboration with a community-based needle exchange program in Harlem that provides antiviral therapy for hepatitis C to persons who inject illicit drugs.


SUNY Downstate HIV-related research

  • National Institute of Allergy and Infectious Diseases, Women's Interagency HIV Study: Major aims of this study are to examine the natural history of HIV infection in women, and to investigate factors related to the rate and type of HIV disease progression. Contact: jack.dehovitz@downstate.edu
  • U.S. Public Health Services Center/SAMHSA Targeted Expansion Program for Substance Abuse Treatment and HIV/AIDS: The purpose of this project is to expand and enhance substance abuse treatment services in conjunction with HIV/AIDS services for high-risk substance abusing adults in Central Brooklyn, NY. Contact: jack.dehovitz@downstate.edu
  • Fogarty International Center SUNY AIDS International Training Program: The overall goal of this program is to provide HIV epidemiological and clinical training to physicians and scientists from the Czech Republic, Poland, Hungary, the Baltics, Estonia, Armenia, and Russia. Contact: jack.dehovitz@downstate.edu. The overall goal of this program is to provide HIV epidemiological and clinical training to physicians and scientists from the Czech Republic, Poland, Hungary, the Baltics, Estonia, Armenia, and Russia. Contact: jack.dehovitz@downstate.edu

Mechanisms of Microbial Resistance

Drs. David Landman and John Quale perform borough-wide surveillance studies examining the epidemiology of problematic nosocomial pathogens. In the Infectious Diseases Research Laboratory, molecular mechanisms contributing to bacterial multi-drug resistance are investigated, and susceptibility testing of investigational novel agents is performed. The goal is to understand the transmission of resistant strains and to identify potential new therapeutic regimens.

Contact john.quale@downstate.edu and david.landman@downstate.edu


SUNY-Downstate/Kings County Hospital Center STI Research Center

Our staff are currently involved in exciting studies of the natural history, diagnosis and management of STIs and genitourinary tract infections. Over the years funding for these efforts has been provided by industry, the NIH, CDC, as well as state and local departments of health.


At the Brooklyn VA:

Contact jana.preis@va.gov or larry.lutwick@va.gov

  • Prevalence of stronglyloides exposure among immunocompromised patients at the VA hospital
  • Prospective evaluation on efficacy of upgraded isolation precautions for patients with highly resistant gram negative microorganisms colonization
  • 10 year retrospective review of post-surgical complications among HIV/AIDS patients
  • 5 year retrospective review of blood stream infections among patients with ESRD on HD
  • 10 year retrospective review of Efavirenz safety among VA hospital patients with diagnosis of PTSD

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