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SUNY Downstate Medical Center

Division of Infectious Diseases

Research

Research is a strong component of the educational experience of all Infectious Diseases Fellows. Here is a sampling of current research projects currently underway. Please look back frequently for additions.

Any one who is interested in participating in research either as a patient who would like to enroll or someone who is interested in getting research experience can discuss with the contact person listed.

SUNY Downstate HIV-related research

  • National Institute of Allergy and Infectious Diseases, Women's Interagency HIV Study: Major aims of this study are to examine the natural history of HIV infection in women, and to investigate factors related to the rate and type of HIV disease progression. Contact: jack.dehovitz@downstate.edu
  • U.S. Public Health Services Center/SAMHSA Targeted Expansion Program for Substance Abuse Treatment and HIV/AIDS: The purpose of this project is to expand and enhance substance abuse treatment services in conjunction with HIV/AIDS services for high-risk substance abusing adults in Central Brooklyn, NY. Contact: jack.dehovitz@downstate.edu
  • Fogarty International Center SUNY AIDS International Training Program: The overall goal of this program is to provide HIV epidemiological and clinical training to physicians and scientists from the Czech Republic, Poland, Hungary, the Baltics, Estonia, Armenia, and Russia. Contact: jack.dehovitz@downstate.edu.

Quale / Landman Laboratory - Mechanisms of Microbial Resistance

Drs. David Landman and John Quale perform borough-wide surveillance studies examining the epidemiology of problematic nosocomial pathogens. In the Infectious Diseases Research Laboratory, molecular mechanisms contributing to bacterial multi-drug resistance are investigated, and susceptibility testing of investigational novel agents is performed. The goal is to understand the transmission of resistant strains and to identify potential new therapeutic regimens.

Contact john.quale@downstate.edu and david.landman@downstate.edu

Eilertson Laboratory - Epidemiology of Gram Negative Resistance

Bacteria are highly plastic with large accessory genomes. Enterobacteriaceae such as Klebsiella and Enterobacter can accept, modify and transmit plasmid-mediated resistance to many classes of antibiotics. I use qPCR assays and high throughput sequencing to examine the spread of antibiotic resistance genes, such as extended-spectrum beta-lactamases and carbapenemases, as well as virulence factors within successful genetic backgrounds (Klebsiella pneumoniae ST258, E. coli ST131, Enterobacter ST171). Recently, I have examined outcomes in carbapenem-resistant Enterobacteriaceae infected end-stage renal disease patients and will focus on the hemodialysis population to identify the burden of ESBL and CRE colonization and look to improve our ability to identify transmission events between patients.

SUNY Downstate / Kings County Hospital Center STI Research Center

SUNY Downstate is lucky to have one of the only hospital based STD Clinics in NYC, affiliated with an academic institution. In over thirty years of operation, the clinic has served as a primary site for many studies of the natural history of the various STDs, behavioral and social determinants of disease acquisition, diagnosis and treatment of these conditions and their interactions with HIV infection. Collaborations with the CDC, the NYC-DOHMH and the  biomedical industry have been common.

At the Brooklyn VA:

Contact jana.preis@va.gov or larry.lutwick@va.gov

  • Prevalence of stronglyloides exposure among immunocompromised patients at the VA hospital
  • Prospective evaluation on efficacy of upgraded isolation precautions for patients with highly resistant gram negative microorganisms colonization
  • 10 year retrospective review of post-surgical complications among HIV/AIDS patients
  • 5 year retrospective review of blood stream infections among patients with ESRD on HD
  • 10 year retrospective review of Efavirenz safety among VA hospital patients with diagnosis of PTSD