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The School of Graduate Studies
Faculty Research in Neural and Behavioral Science
Charles Abrams, Our laboratory uses a variety of cellular/molecular and electrophysiological techniques to study the roles of gap junction proteins in normal function of peripheral and central nervous system glia. We also study the pathogenesis of several diseases caused by mutations in human gap junction proteins, including Charcot-Marie-Tooth disease and Pelizeus-Merzbacher disease.
Juan Marcos Alarcon, Molecular and cellular mechanisms underlying the interaction between distinct forms of synaptic plasticity in the CA1 area of the rodent hippocampus: consequences at synaptic, dendritic and neuron-wide level and impact on the hippocampal network.
Alison E. Baird, Studying the predictors of clinical and tissue outcome after stroke and predictors of stroke risk. Methods used include neurovascular imaging (MRI, MRA, and CT) and cellular and molecular profiling of the peripheral blood (gene expression profiling and flow cytometry). Development and evaluation of novel diagnostic and therapeutic approaches for stroke.
Randall L. Barbour, Optical tomographic imaging methods for the evaluation of tissue function.
Frank C. Barone , Basic scientific study of Cerebrovascular dieases with focus on ischemic stroke, vascular dementia and trauma; Development of animal disease models that can translate well to man and will facilitate our understanding of disease biology, pathology and signaling, and biomarkers in order to impact drug discovery and advances in therapeutic interventions; Persue close collaborations with Clinical Researchers and Neuroscientists to help make Translational Medicine a reality.
Peter Bergold, Analysis of the pathophysiology of neuronal disorders.
Riccardo Bianchi, What are the mechanisms of altered plasticity associated with epilepsy, Fragile X mental retardation, and Down syndrome? We study the glutamate- and acytylcholine-mediated modulation of intrinsic and synaptic properties in hippocampal neurons and mouse models of these disorders.
Andrea Bibbig, Computational Neuroscience. Investigation of the mutual interactions of different brain oscillations (beta oscillations, gamma oscillations and very-fast oscillations) during normal and pathological brain activity, plasticity of different kinds of synapses (chemical excitatory and inhibitory synapses and electrical synapses), and how oscillations and plasticity influence each other and the functional consequences this interaction has for normal and pathological brain activity.
Ivan Bodis-Wollner, High frequency (gamma) changes in the EEG are related to saccadic eye movements performed voluntarily or cued by different auditory and visual stimuli or without eye movements (covert visuo-spatial attention).
William J. Brunken, Our work includes the study of laminins and neutrins in morphogenesis of the retina and cerebellum and the role of matrix in retinal vascularization. Our goal is to identify the role of these molecules in human disease and to incorporate them into neural repair strategies.
John K. Chapin, Development and utilization of technologies for recording electrophysiologically from large populations of neurons in sensory and motor areas of the brain; use of this information to control external devices.
Jeremy Coplan, Nonhuman primate studies which examine the long-term biobehavioral impact of early life stress incurred by the offspring of mothers exposed to unpredictable foraging; neurohistological correlates of antidepressant action in primate models of mood and anxiety disorders, with a specific focus on hippocampal neuroplasticity.
Howard A. Crystal, Clinicopathologic and epidemiologic studies of memory and cognition in normal aging and dementia.
Diana L. Dow-Edwards, Developmental toxicity of Drugs of Abuse including cocaine and THC; effects on cerebral function, behavior and cognition in the rat.
André A. Fenton, Studies of spatial cognition, memory and hippocampal function in humans, rats, and mice using behavioral, functional lesion, electrophysiological, and computational methods.
Steven E. Fox, Hippocampal EEG rhythms and location-specific firing of cells.
Joseph T. Francis, Development of a fully integrated Brain Machine Interface (BMI) for the control of prosthetic limbs.
Alan R. Gintzler, Biochemistry of addiction/narcotic tolerance; G protein signaling cascades; gender-dependent (e.g. estrogen, progesterone) regulation of opioid activity and pain sensitivity.
Alejandro Iván Hernández, Understanding the molecular mechanisms regulating long-term synaptic plasticity and the alterations of those mechanisms associated with neurodegenerative disorders and drug addiction.
Sabina Hrabetova, Biophysical properties of the brain extracellular space important for neurotransmission, neurotrophic effects, drug delivery, general electric activity, and basic cellular homeostasis. Focus: role of glia and extracellular matrix. Interdisciplinary approach: imaging, electrophysiology, computer modeling.
Xian-Cheng Jiang, Creation and development of mouse models (transgenic and gene knock-out) for the study of the relationship between lipid metabolism and heart disease. Use of transgenic approach to perform functional studies of two lipid transfer proteins: phospholipid transfer and cholesteryl ester transfer proteins.
Ira Kass, Mechanisms of hypoxic and ischemic neuronal damage. Of particular interest are the cellular electrophysiologic, biochemical and molecular biological changes that occur during ischemia and how anesthetics and other pharmaceutical agents influence these changes.
John Kubie, Rat hippocampus: navigation, learning and memory.
Jenny Libien, Function of retinoids (vitamin A and its analogues) and retinoid transport proteins (RBP, TTR) in the central nervous system. The birth and survival of new neurons in the adult dentate gyrus in neurodegenerative diseases.
Douglas S.F. Ling, Properties of cortical inhibitory circuits and the regulation of excitatory transmission; mechanisms of epilepsy and synaptic plasticity; changes in cortical physiology following traumatic brain injury.
William W. Lytton, Computer modeling of neurons and neural networks: applications to epilepsy, stroke, and learning and memory.
Lisa Merlin, Electrophysiology; role of metabotropic glutamate receptors in epilepsy; network properties of the hippocampus; signal transduction mechanisms in epileptogenesis.
Hillary Michelson, Functional connectivity, morphology, and development of hippocampal inhibitory circuitry; interneuron function in epilepsy.
Suzanne S. Mirra, Neuropathology of Alzheimer's disease and overlap with other neurodegenerative disorders and cerebrovascular disease.
Foroozan Mokhtarian, Virally-triggered and experimentally induced autoimmune inflammatory demyelinating models used to study the pathogenesis and to test potential therapeutic agents for MS.
Herman Moreno, Use of fMRI, electrophysiology, and calcium imaging to study brain metabolism in Alzheimer's disease and other neurodegenerative diseases.
Robert U. Muller, Molecular, synaptic and network foundations of spatial memory and learning in rodents: involvement of the hippocampus and relations to hippocampal-dependent memory in humans.
Nicholas J. Penington, Neuropharmacology of serotonergic (5-HT) neurons: patch clamp studies of 5-HT receptor modulation by protein kinases, signal transduction mechanisms, serotonergic drug effects on ion channels.
Katherine L. Perkins, Synaptic transmission in the hippocampus, primarily GABAergic transmission. Current focus is on the depolarizing GABA response and interneuron networks.
James B. Ranck, Jr., Limbic neuron firing and spatial behavior, navigation, topology of neuronal firing rate space.
Leonard A. Rosenblum, Primate behavioral and brain development, models of psychopathology, psychopharmacology, psychoimmunology, factors affecting development of obesity.
Alan P. Rudell, Electrical brain responses to recognizable images (words, pictures, faces) are recorded and related to acquired perceptual skills (e.g. reading ability).
Todd C. Sacktor, Protein kinase C isozymes, PKMζ, long-term potentiation, long-term depression, synaptic plasticity, hippocampus, learning and memory.
Frank R. Scalia, Development of the visual system and regeneration of the optic nerve; role of Eph receptor tyrosine kinases and their ligands in the visuotopic map formation.
Sheryl S. Smith, Investigation of neurosteroid effects on GABA-A receptor plasticity and its relevance for altered hippocampal physiology, as well as anxiety and epilepsy.
Armin Stelzer, Hippocampus, synaptic plasticity, role of synaptic inhibition, regulation of GABA receptor.
Mark G. Stewart, Physiology and pathophysiology of limbic neurons and limbic neuron circuits.
Gladys N. Teitelman, Cellular and molecular analysis of pancreatic islet cell differentiation; isolation of insulin precursor cells and characterization of the signals that control their maturation.
Henri Tiedge, Regulation of neuronal gene expression; RNA transport in neurons; mechanisms of local protein synthesis; long-term synaptic plasticity; Alzheimer's disease; tumor biology.
Keith Williams, Structure, function, pharmacology, and regulation of glutamate receptors.
Robert K.S. Wong, Calcium and intercellular signaling and circuit organization of the hippocampus.