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Research Update
December 2010

Chaiya Laoteppitaks, MD

Chief Resident of Research

Richard Sinert, DO

Director of Research

Savitri Singh, MD

Research Fellow

Lorenzo Paladino, MD

Assistant Director of Research

Shahriar Zehtabchi, MD

Associate Director of Research

Shweta Malhotra, PhD

Clinical Scientist and Research Coordinator


Ongoing Grants


EEG in the ED – (NIH)

Hyaluronidase – (Baxter)

Research Fellow – (ECRIP:  Empire Clinical Research Investigator Program)

Society for Airway Management

Electronic Chapters

Tsang K, Sinert RH, Li J. Tuberculosis. eMedicine from WebMD. Updated November 05, 2010.

Brandler ES, Sinert RH. Shock, Cardiogenic. eMedicine from WebMD. Updated January 26, 2010.

Aherne A, Sinert RH. Glaucoma, Acute Angle-Closure. eMedicine from WebMD. Updated November 10, 2010.

Welcome to our Academic Associates!!!

Please continue to welcome our research students/ Academic Associates to the clinical area. They are invaluable to the success of our projects, so please make them feel welcome and provide them with any assistance they may need in identifying patients who are eligible for our studies. The research students have expressed that the residents have been very helpful in identifying patients, teaching them, and making them feel at home. Thank you very much!

Upcoming studies

Several new studies will be starting soon and we need help from the residents.

1. Platelet-Oriented Inhibition in New TIA and minor ischemic stroke

(POINT) Trial (NIH)

To determine whether clopidogrel 75 mg/day by mouth after a loading dose of 600 mg of clopidogrel is effective in preventing major ischemic vascular events (ischemic stroke, myocardial infarction, and ischemic vascular death) at 90 days when initiated within 12 hours of TIA or minor ischemic stroke onset in patients receiving aspirin 50-325 mg/day (with a dose of 162 mg daily for 5 days followed by 81 mg daily strongly recommended). Drs. Chatterjee, Sinert, Backster

2. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-II (NIH)

To determine the therapeutic benefit of intensive SBP treatment (SBP<140 mmHg) compared with standard SBP treatment (SBP<180 mmHg) in reducing the proportion of patients with death and disability (mRS of 4-6) at Day 90 among subjects with ICH treated within 3 hours of symptom onset. Drs. Brandler, Sinert

3. Potential of rtPA for Ischemic Strokes with Mild Symptoms (PRISMS) Trial

To definitively determine the efficacy of IV rtPA treatment of ischemic strokes with mild deficits (defined as NIH

Stroke Scale [NIHSS] score ≤5 and not clearly disabling) within 4.5 hours of onset. Drs. Chatterjee, Sinert

4. Angioneurotic Edema

a) Descriptive study - Prevalence, association with medications and outcomes of angioneurotic edema in our ED

b) Investigative Study - What is the percentage of patients we diagnose with angioneurotic edema who really have hereditary angioedema

c) Experimental Study - Ecallantide for ACEI-induced angioedema (NIH) Drs. Paladino, Sinert

Patients to enroll in research studies


  • PROCESS Patients –Sepsis with SBP<90 or Lac>4
  • All new onset diabetics – Please contact Endocrinology, Dr. Banerji (917-613-1294)
  • DKA patients –Please contact Endocrinology, Dr. Banerji (917-613-1294)
  • All critical medical patients are to be enrolled into critical care database.  Please send Mag, Phos, and shock panel with the initial BMP.
  • All ETOH suspected patients
  • Antibiotics and simple hand lacerations – no tendon, bone, vessels or nerve involvement.  Please page Dr. Singh at 917-760-1790, from 8am-5pm M-F only.
  • Ultrasound and angioedema – Please contact Dr. Bright or any of the Ultrasound Division faculty
  • Ultrasound guided vs. landmark guided shoulder blocks in anterior shoulder dislocations – Please contact Dr. Romney or any of the Ultrasound Division faculty 


  • PROCESS Patients – sepsis with SBP<90 or Lac>4
  • All new onset diabetics – Please contact Endocrinology, Dr. Banerji (917-613-1294)
  • DKA Patients – Please contact Endocrinology, Dr. Banerji (917-613-1294)
  • All major trauma patients in CCT to be enrolled in trauma database
  • All trauma and critical medical patients are to be enrolled into critical care database.  Please send Mag and Phos levels with the initial BMP.
  • All ETOH suspected patients
  • Antibiotics and simple hand lacerations – no tendon, bone, vessels or nerve involvement.  Please page Dr. Singh at 917-760-1790, from 8am-5pm M-F only.
  • KAVI – Kings Against Violence Initiative
  • Ultrasound guided vs. landmark guided shoulder blocks in anterior shoulder dislocations – Please contact Dr. Romney or any of the Ultrasound Division faculty

Authors Needed

Writing an eMedicine chapter is a great way to learn a subject, buff your CV and earn points toward satisfying your academic requirement. Topic availability changes frequently, so just ask any of the faculty mentors or the research division if you are interested in participating in this highly rewarding endeavor…

eMedicine Chapter faculty mentors include: Sinert, Paladino, Doty, Silverberg, Gleyzer (ID), Peacock, Erogul, Agoritsas (Peds) & Weiner (Tox), Quinn (sports Med / Ortho)

Additional motivated residents are still needed to join the rat team, and if anyone else is interested, please see Drs. Paladino.

Animal Lab Projects
Institutional Animal Care and Use Committee certification (only for the animal model you are working on) needs to be completed for all current and future Animal Lab researchers (Faculty, Residents and Academic Associates). This is an online course (under Web Course and Exams):

Be sure to “link records to institution”

A Quick Look at

Current Active Projects
Red Studies Need More Participants!

  • Does Tight Glucose Control with Insulin Improve the Outcome of IDDM / NIDDM Rats after Uncontrolled Hemorrhage? DM rats exhibit greater blood loss and higher lactates than controls. Will pretreatment with insulin correct this difference? Drs. Sinert, Paladino

IRB Certification

  • If you have not gotten your IRB certification or it has been at least two years since you certified, please do so as we need to be certified as a department.

All attendings & residents are required to complete certification for “Human Participants Protection Education.” Please sign on to the CITI (Collaborative IRB Training Initiative) training program below:

Research Block

You must speak to Dr. Zehtabchi or Dr. Laoteppitaks one month prior to your rotations.

The goal of the rotation is a published pubMed Indexed manuscript.  Depending on experience, available options include:  Visual Diagnosis, Brief Report, Case Report, Review, or you may assist with one of the ongoing Original Research Projects.

During your rotation, join us at the research meeting on Wednesday afternoons in Dr. Sinert’s office at 12 PM.

Policy: Conference Reimbursement

For abstract presenters, our Department will reimburse you for your hotel and meeting registration.   This applies to both residents and attendings, and is in addition to your CME money. Due to the new changes in department reimbursement policy, you need to contact Ms. Patella before paying for your registration, or booking your hotel or transportation. Please refer to the department website (under Research) for details on how to obtain reimbursement.

Policy: Authorship and Contributorship

Byline Authors

An "author" is generally considered to be someone who has made substantive intellectual contributions to a published study, and biomedical authorship continues to have important academic, social, and financial implications. (1) In the past, readers were rarely provided with information about contributions to studies from those listed as authors and in acknowledgments. (2) Some journals now request and publish information about the contributions of each person named as having participated in a submitted study, at least for original research. Editors are strongly encouraged to develop and implement a contributorship policy, as well as a policy on identifying who is responsible for the integrity of the work as a whole.

While contributorship and guarantorship policies obviously remove much of the ambiguity surrounding contributions, it leaves unresolved the question of the quantity and quality of contribution that qualify for authorship. The International Committee of Medical Journal Editors has recommended the following criteria for authorship; these criteria are still appropriate for those journals that distinguish authors from other contributors.

  • Authorship credit should be based on 1) substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data; 2) drafting the article or revising it critically for important intellectual content; and 3) final approval of the version to be published. Authors should meet conditions 1, 2, and 3.
  • When a large, multi-center group has conducted the work, the group should identify the individuals who accept direct responsibility for the manuscript (3). These individuals should fully meet the criteria for authorship defined above and editors will ask these individuals to complete journal-specific author and conflict of interest disclosure forms. When submitting a group author manuscript, the corresponding author should clearly indicate the preferred citation and should clearly identify all individual authors as well as the group name. Journals will generally list other members of the group in the acknowledgements. The National Library of Medicine indexes the group name and the names of individuals the group has identified as being directly responsible for the manuscript.
  • Acquisition of funding, collection of data, or general supervision of the research group, alone, does not justify authorship.
  • All persons designated as authors should qualify for authorship, and all those who qualify should be listed.
  • Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.

Some journals now also request that one or more authors, referred to as "guarantors," be identified as the persons who take responsibility for the integrity of the work as a whole, from inception to published article, and publish that information. .

The order of authorship on the byline should be a joint decision of the co-authors. Authors should be prepared to explain the order in which authors are listed. For further information on this and other policies visit

Get Involved in Research!!

All faculty and residents are part of the Research Committee. On the first Wednesday of every month, ongoing projects are reviewed and new research is discussed. All Residents must contact Dr. Zehtabchi & Dr. Laoteppitaks at least one month prior to the start of your Research Rotation to setup a project.  If you fail to do this your research time will be converted into clinical shifts.  Everyone is encouraged to participate in at least one study (regardless of your PGY level) throughout the academic year.

Feel free to contact the Research Division:

Dr. Sinert    

Dr. Zehtabchi

Dr. Lorenzo Paladino

Dr. Chaiya Laoteppitaks

Dr. Shweta Malhotra

Dr. Savitri Singh

Research Office Hours

Every Wednesday Dr. Sinert will be available in his office (10 am to 4 pm) to meet with faculty and residents on research issues.  Just contact Dr. Sinert one week in advance to setup a time