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Department of Cell Biology Faculty

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Ademuyiwa Aromolaran, PhD

Assistant Professor, SUNY Downstate

Research Scientist Cardiovascular Research Group
New York Harbor Health Care System (VAMC)

Tel: (718) 836-6600, Ext. 3810 • Fax: (718) 630-3796

e-mail: ademuyiwa.aromolaran@va.gov

Molecular basis of cardiac arrhythmias

One of the major areas of my research lab is to develop tools and comprehensive approaches that will allow us to vigorously assess the functional properties of K channels in heart and provide mechanistic insights into arrhythmias including long QT syndrome (LQTS), underlain by congenital mutations in subunits (KCNQ1, KCNE1, hERG 1a/1b) that form the delayed rectifier K current (IK) and atrial fibrillation (AF).

Recently, this research topic has contributed significantly to our understanding of the critical role of trafficking and gating mechanisms in the pathological decreases in the rapidly (IKr) and slowly (IKs) activating delayed rectifiers leading to prolongation of the action potential duration and predisposing to fatal arrhythmias. Because LQT can also be acquired in diabetes, we have recently developed a streptozotocin-induced diabetic adult guinea pig model and are currently characterizing the patho-physiology of major cardiac ionic (Ca, K, Na) mechanisms involved in normal sinus rhythm.

AF, or rapid and irregular activation of the atrium, is the most common arrhythmia in both males and females. Obesity is also a key contributor to the expanding prevalence of AF. In this context, my lab has also established a high-fat diet induced adult obese guinea pig that will provide crucial insights into the ionic mechanisms that predispose obese patients to arrhythmias.

Experimental protocols are conducted in isolated cardiomyocytes and heterologous expression systems (HEK293, CHO cells), using electrophysiological, biochemical, imaging and molecular techniques; as well as programmed electrical stimulation in Langerdoff perfused isolated heart in collaboration with Dr. Mohamed Boutjdir.

Selected Recent Publications

  • Aromolaran AS and Boutjdir M. (2017). Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial Fibrillation. Front. Physiol. 8:431. doi: 10.3389/fphys.2017.00431
  • Srivastava U, Aromolaran AS, Fabris F, Lazaro D, Kassotis J, Qu Y, Boutjdir M. (2017). Novel function of α1D L-type calcium channel in the atria. Biochem Biophys Res Commun, 482, 771-776. PMID: 27884747
  • Aromolaran, AS, Colecraft, HM, Boutjdir M. (2016). High-fat diet-dependent modulation of the delayed rectifier K+ current in adult guinea pig atrial myocytes. Biochem Biophys Res Commun, 474, 554-559. PMID: 27130822
  • Puckerin A, Aromolaran KA, Chang DD, Zukin RS, Colecraft HM, Boutjdir M, Aromolaran AS. (2016). hERG 1a (LQT2) C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms. Heart Rhythm, 13, 1121-30. PMID:  26775140
  • Aromolaran AS, Subramanyam P, Chang DD, Kobertz WR, Colecraft HM. (2014). Distinct long QT syndrome-1 (LQT1) mutations in KCNQ1 C-terminus suppress IKs using different mechanisms. Cardiovascular Research, 104, 501-511. PMID: 25344363, PMCID: PMC4296111
  • Snopko RM, Aromolaran AS, Karko KL, Ramos-Franco J, Blatter LA, Mejia-Alvarez R. (2007). Cell culture modifies Ca2+ signaling during excitation-contraction coupling in neonate cardiac myocytes. Cell Calcium, 41, 13-25. PMID: 16908061
  • Aromolaran AS, Zima AV, Blatter LA. (2007). Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. American Journal of Cell Physiology, 293, C106-C118. PMID: 17344311
  • Aromolaran AS & Blatter LA. (2005). Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells. American Journal of Cell Physiology, 289, C1426-C1436. PMID: 16093279