Cancer Research Program

FACULTY AND RESEARCH INTERESTS

Research in the lab of Dr. Olcay Batuman is focused on pathogenesis of the plasma cell cancer, multiple myeloma; endothelial cells colonies resemble angioblasts and affect disease progression. Colony forming endothelial progenitor cells cultured directly from myeloma patients resemble embryonic hemangioblasts and adversely affect disease progression.

The lab of Dr. Henri Tiedge studies the expression of BC200 RNA in invasive breast cancer. Untranslated BC200 RNA is a translational repressor that is expressed in malignant breast tumor cells that have acquired invasive potential. Areas with invasive tumor cells are indicated (T) in dark field (left) and bright field (right) photomicrographs. BC200 expression in invasive tumor areas is revealed by autoradiographic silver grains (pinkish-white in the dark field photomicrograph). No BC200 expression is observed in normal lobular and stromal tissue. BC200 may be a good biomarker of cancer progression.

Bascic Science Facullty
– Olcay Batuman
– Stacy Blain
– Brahmin Chaquor
– William Chirico
– Miriam Feuerman
– Mahmood Hussain
– Christopher Lange
– John Lewis
– Maureen McLeod
– Joseph Michl
– Allan Norin
– George Ojakian
– Sylvia Patan
– Matthew Pincus
– Edward Quadros
– Christoper Roman
– Gladys Teitelman
– Henri Tiedge
Clinical Faculty
– Ovadia Abuladia
– Randall Barbour
– Ivan Colon
– Susan Gottesman
– Richard J. Macchia
– Ozul Muneryyirci-Delale
– Robert Raffaniello
– Sreedhar Rao
– Sheldon P.Rothenberg
– Marvin Rotman
– William B. Solomon
– Michael Zenilman

Basic Science Faculty

Olcay Batuman
Anatomy & Cell Biology

Pathogenesis of the blood cancer multiple myeloma

Stacy Blain
Anatomy & Cell Biology

Regulation of G1 Cdks and Ckis During the Cell Cycle and Cancer,
Breast Cancer Gene Therapy

Brahmin Chaquor
Anatomy & Cell Biology

The Biological Effects of Mechanical Forces:
Role of the CCN Proteins in Mechanotransduction

William Chirico
Anatomy & Cell Biology

Novel 46 kDa basic Fibroblast Growth Factor Binding Protein

Miriam Feuerman
Biochemistry

Genetic Regulation of Gene Expression During Liver Regeneration
and Tumorigenesis

Mahmood Hussain
Anatomy & Cell Biology

Molecular Mechanisms of Intestinal Lipoprotein Assembly

Christopher Lange

Cellular radiation lethality in terms of DNA double-strand break rejoining kinetics

John Lewis
Anatomy & Cell Biology

Mechanism of Interferon Action of Interferons

Maureen McLeod
Microbiology & Immunology

Regulation of Signaling Molecules Important for Development,
Cell Cycle and Growth

Joseph Michl
Pathology

Novel Methods in the Diagnosis and Treatment of Pancreatic Cancer

Allan Norin
Anatomy & Cell Biology

Tumor Immunology, Molecular Basis of Cancer, Transplant Immunology

George Ojakian
Anatomy & Cell Biology

The Importance of Adherens Junctions and Desmosomes in Regulation of
Epithelial-Mesenchyme

Sybill Patan
Anatomy & Cell Biology

Intussusceptive Microvascular Growth (IMG)

Matthew Pincus
Pathology

Protein Structure and Oncogenesis

Edward Quadros
Biochemistry

Christoper Roman
Microbiology & Immunology

Lymphocyte Development; Mechanisms of Oncogenesis, Renal carcinoma,
leukemia and lymphom

Gladys Teitelman
Anatomy & Cell Biology
Cell Lineage and Differentiation of Insulin-Producing Cells During
Embryonic Development and Pancreatic Islet Regeneration

Henri Tiedge
Physiology & Pharmacology

RNA control of gene expression in neurons and tumor cells

Clinical Faculty

Ovadia Abuladia
OBS/GYN

Phase II Clinical Trial of Weekly Docetaxel in Advanced Recurrent and
Refractory Endometrial Cancer

Randall Barbour
Pathology

Mammographic Imaging by optical Tomography

Ivan Colon
Urology

Prostate Cancer: Cryosurgery; High Intensity Focused Ultrasound,
Hispanic community issues

Susan Gottesman
Dept of Pathology

Leukemia and Lymphoma

Richard J. Macchia
Urology

Prostate cancer: screening - effectiveness in decreasing mortality and
psychosocial aspects of PSA based screening, Racial differences and
community outreach and education

Uroradiology-imaging for urologic malignancies

Ozul Muneryyirci-Delale
OBS/GYN

Study to Evaluate Efficacy and Safety of Two Doses of J867 Versus
Doses of Placebo in Subjects with Uterine Leiomyomata

Robert Raffaniello
Medicine

H Pilori Infection in Patient Populations at High Risk of Gastric Cancer

Sreedhar Rao
Pediatrics

Specimen Banking

Sheldon P. Rothenberg
Medicine

Raymond and Frances Church Biomedical Research Fund for Research of
Diseases of the Blood

Marvin Rotman
Radiation Oncology

Clinical Trials in Radiation Oncology

William B. Solomon
Medicine

Trial Comparing Targretin Capsules/Cisplatin/Vinorelbine
Versus Cisplatin/Vinorelbine in Chemotherapy-Naïve Patients

Michael Zenilman
Surgery

Pancreatic Physiology