Fibroblast growth factor 2 (FGF2) regulates rRNA transcription, in part, by localizing with rRNA genes and directly interacting with the upstream binding factor (UBF), an architectural transcription factor, in the nucleolus. Confocal images from Dr. William Chirico's lab show the colocalization (panel c, yellow) of FGF2 (panels a and c, green) and UBF (panels b and c, red)..
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