The imaging surface of the retina is mapped point for point onto the visual centers of the brain, providing the brain with a coherent view of the visual world. The formation of these visuotopic maps, which are essential for normal vision, is being studied during development and in models of optic nerve regeneration.
Teaching responsibilities:
I am responsible for a sub-block covering the introductory anatomy and development of the human central nervous system in the Neuroscience block.
SELECTED RECENT PUBLICATIONS
1. Scalia, F. The termination of retinal axons in the pretectal region of mammals. J. Comp. Neurol. 145:223-257, 1972.
2. Scalia, F. and Winans, S. The differential projections of the olfactory bulb and accessory olfactory bulb in mammals. J. Comp. Neurol. 161:31-56, 1975.
3. Scalia, F. Synapse formation in the olfactory cortex by regenerating optic axons: ultrastructural evidence for polyspecific chemoaffinity. J. Comp. Neurol. 263:497-513, 1987.
4. Scalia, F., Grant A.C., Reyes, M. and Lettvin, J.Y. Functional properties of regenerated optic axons terminating in the primary olfactory cortex. Brain Res. 685:187-197, 1995.
5. Scalia, F., Eisner, S., Galoyan, S.M., Harris, E., Su, W. and Lettvin, J.Y. A compartment-based, asymmetric representation of the retina in an induced projection to the olfactory cortex. J. Comp. Neurol. 383:415-427, 1997.
6. Scalia, F., Simai, D., Harris, B. and Eisner, S. Unequal representation of the temporal and nasal retina in an anomalous projection to the lateral thalamus. J. Comp. Neurol. 416:213-223, 2000.
7. Bach, H., Feldheim, D.A., Flanagan, J.G. and Scalia, F. Persistence of graded EphA/ephrin-A expression in the adult frog visual system. J. Comp. Neurol. 467:549-565, 2003.
8. Bach, H., Arango, V., Feldheim, D.A., Flanagan, J.G. and Scalia, F. Fiber order of the normal and regenerated optic tract in the frog (Rana pipiens). J.Comp. Neurol. 477:43-54, 2004.
9. Scalia, F. and Feldheim, D.A. Eph/ephrin A- and B- family expression patterns in the leopard frog (Rana utricularia). Dev. Brain Res. 158:102-106, 2005.
10. Yagita, Y., Barjis, I., Hecht, M., Bach, H., Feldheim, D.A. and Scalia, F. Partial nucleotide sequences and expression patterns of frog (Rana pipiens)ephrin-A2 and ephrin-A5. Dev. Brain Res. 159:72-77, 2005 (cover article).
Bach, H., Feldheim, D.A., Flanagan, J.G. and Scalia, F. Persistence of graded EphA/ephrin-A expression in the adult frog visual system. J. Comp. Neurol. 467:549-565, 2003.
Bach, H., Arango, V., Feldheim, D.A., Flanagan, J.G. and Scalia, F. Fiber order of the normal and regenerated optic tract in the frog (Rana pipiens). J.Comp. Neurol. 477:43-54, 2004.
Scalia, F. and Feldheim, D.A. Eph/ephrin A- and B- family expression patterns in the leopard frog (Rana utricularia). Dev. Brain Res. 158:102-106, 2005.
Yagita, Y., Barjis, I., Hecht, M., Bach, H., Feldheim, D.A. and Scalia, F. Partial nucleotide sequences and expression patterns of frog (Rana pipiens)ephrin-A2 and ephrin-A5. Dev. Brain Res. 159:72-77, 2005.